Isomeric Effect on the Pharmacokinetic Behavior of Anticancer Cu^II Mixed Chelate Complexes: Experimental and Theoretical Approach

Abstract

Abstract:We present herein the results of a pharmacokinetic (PK) study of Cu II mixed-chelate coordination compound CasIIILa {[Cu(5,6-dimethyl-1,10-phenanthroline)(acetylacetonate)-(H 2 O)]NO 3 }, which belongs to the antineoplastic family of compounds known as Casiopeínas. The main interest in this molecule lies in the big difference in its lethal dose and PK parameters in Wistar rats compared with its structural isomer CasIII-Ea {[Cu(4,7-dimethyl-1,10-phenanthroline)(acetylacetonate)(H 2 O)]-NO 3 }. For instance, the half-lives of these compounds are 9.6 ± 1.15 and 48 ± 4.6 h for CasIII-La and CasIII-Ea, respectively. The differences in the half-lives have been attributed to

Synthesis of Two Mononuclear Schiff Base Metal (M = Fe, Cu) Complexes: MOF Structure, Dye Degradation, H2O2 Sensing, and DNA Binding Property

“…25,45−47 The Schiff base ligands and the corresponding metal complexes have the active site that interacts with the DNA of the cancer cell. 48,49 Recently, metal–organic framework systems have been used in biomedicine, as reported by Chen et al 50,51…”

Anti-proliferative, pro-apoptotic and anti-invasive effect of the copper coordination compound Cas III-La through the induction of reactive oxygen species and regulation of Wnt/β-catenin pathway in glioma

“…In addition, results of a molecular dynamics study suggest that the topology and effective volume of Cas III-La allows it to cross cellular membranes by a diffusion process more easily than its analog Cas III-Ea ([Cu(4,7-dimethyl-1,10-phenanthroline)(acetylacetonate)]NO 3 ). Our results allow us to explain not only the differences seen in the antiproliferative activity of the drug on phagocytic (macrophages) and non-phagocytic (lymphocytes) cells, but also the completely different pharmacodynamic parameters observed for Cas III-La and CasIII-Ea 21 .…”

Studies on DNA binding, cleavage, molecular docking, antimicrobial and anticancer activities of Cr(III), Fe(III), Co(II) and Cu(II) complexes ofo‐vanillin and fluorobenzamine Schiff base ligand

“…[ 8–10 ] The Schiff base ligands and the metal complexes possess the active site that can interact with the DNA of the cancer cell. [ 11,12 ]…”

“…[8][9][10] The Schiff base ligands and the metal complexes possess the active site that can interact with the DNA of the cancer cell. [11,12] Fluorine atom, when introduced into a molecule, can change its physical and chemical properties, metabolic stability and its biological activity by affecting the lipophilicity and therefore make better drugs. [13] On the other hand, the position of the fluorine atom in the aromatic ring can also determine receptor selectivity.…”