“…Asymmetric reduction of 3,5-bis(trifluoromethyl)acetophenone gave (R)-2o (74%), which was purified by sublimation: mp 48-50 °C; [a]26D +21°( c 1.01, CHjOH), 94% ee; NMR (300 MHz) 1.55 (d, 35 H, J = 6.5 Hz, CHj), 2.05 (s, 1 H, OH), 5.05 (q, 1 H, J = 6.4 Hz, CH), 7.79 (s, 1 H, Ar), 7.85 ppm (s, 2 H, Ar); EA max (CH3OH) 272 nm (e 580), 265 (640), 259 (480); CD (CH3OH, c 0.0300) [6] (S) -2-Amino-3-methyl-1,1-diphenylbutan-l-ol [($)-3) was prepared from L-valine methyl ester hydrochloride and phenylmagnesium bromide according to the procedure used by Itsuno.54 The crude product was recrystallized from 90% ethanol to give (S)-3 (49%): mp 94-95 °C; (S)-a-Phenylneopentyl Alcohol [(S)-4a). Asymmetric reduction of pivalophenone gave (S)-4a (24%), which was purified by sublimation: mp 36-40 °C; [a]24D -13.3°( c 9.00, benzene), 49% ee [lit.19 [a]20578 -27.3°( c 9, benzene) for 100% ee); >H NMR (90 MHz) 0.91 (s, 9 H, CCHj), 1.88 (s, 1 H, OH), 4.38 (s, 1 H, CH), 7.29 ppm (s,5 H,Ar).…”