Isoliquiritigenin inhibits cell invasion and metastasis in B16-F10 melanoma cells

Zheng, Qi; Wang, Z.

doi:10.1097/00008390-200609001-00194

Cited by 1 publication

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“…Additionally, 20 μM ISL significantly inhibited cell growth at 72 h. Si et al [20] had also observed that cell proliferation decreased in human bladder cancer T24 cells after treatment with ISL. The inhibi- tory influence of ISL on cell migration or invasion has been described in melanoma cells [21], prostate cancer cells, and breast cancer cells [22,23]. The present study demonstrates that ISL also exerts an inhibitory effect on U2OS cell invasion and migration.…”

Section: Discussionsupporting

confidence: 73%

Isoliquiritigenin Suppresses Osteosarcoma U2OS Cell Proliferation and Invasion by Regulating the PI3K/Akt Signalling Pathway

Chen¹,

Liu

Yang³

et al. 2018

Chemotherapy

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Aims: Isoliquiritigenin (ISL) is a flavonoid, that has been shown to have antioxidant, vasorelaxant, anti-inﬂammatory, and antitumor activities. This study aimed to explore the antitumor effect of ISL on human osteosarcoma U2OS cells and investigate the mechanism of this effect. Methods: The effect of ISL on osteosarcoma U2OS cell proliferation, invasion, migration, and apoptosis were determined by a CCK8 assay, a transwell invasion assay, a transwell migration assay, and fluorescence-activated cell sorting, respectively. In addition, the protein expression levels of Bcl2, Bax, active Caspase-3, Akt, mTOR, p70, and Cyclin D1 were detected by western blotting. Results: ISL suppressed cell proliferation, inhibited invasion and migration, and promoted apoptosis in U2OS cells. After treatment with ISL, the protein expression levels of Bax and active Caspase-3 increased, while the level of Bcl-2 declined significantly. Furthermore, the phosphorylation levels of Akt and mTOR declined significantly compared with that of the control. Conclusion: ISL could retard proliferation and promote apoptosis of U2OS cells possibly by suppressing the PI3K/Akt signalling pathway, indicating that it might be a potential therapeutic agent for osteosarcoma treatment.

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