Isoliensinine augments the therapeutic potential of paclitaxel in multidrug‐resistant colon cancer stem cells and induced mitochondria‐mediated cell death
Prasath Manogaran,
Aparna Anandan,
Viswanadha Vijaya Padma
Abstract:Previously we have reported the isoliensinine (ISO) potentates the therapeutic potential of cisplatin in cisplatin resistant colorectal cancer stem cells. The present study evaluates the chemo‐sensitizing potential of the combinatorial regimen of ISO and Paclitaxcel (PTX) on multidrug‐resistant (MDR)‐HCT‐15 cells to reduce the dose requirement of both ISO and PTX. The results of the present study suggest that treatment with the combinatorial regimen of ISO and PTX enhanced the cytotoxic effect with resultant i… Show more
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