Isoleojaponin, a New Halimane Diterpene Isolated from Leonurus japonicus

Abstract

Leojaponin (2), a labdane diterpene, was isolated from the EtOH extract of the herb of Leonurus japonicus together with a new halimane diterpene named isoleojaponin (1). Isoleojaponin has a new diterpene skeleton with a unique cross-conjugated α,β-unsaturated ketone system, Their structures were elucidated by physical and spectroscopic analysis, and the relative configuration of the chiral C-9 carbon was determined by a computational method, and analysis of its possible biogenesis pathways.

Halimane diterpenoids: sources, structures, nomenclature and biological activities

“…53 Agelasine S (157) exerts antibacterial and antifungal activities and is the only derivative of this type difunctionalized at C1 and C3. 165 and Marrubium aschersonii 169 166 ) except 158, which was isolated from Stevia gilliesii 167 (Compositae). The most usual derivatives in this series are those that present oxygenated functions on ring B, normally on carbons C6 and C7 (Fig.…”

Immunomodulatory and antitumour bioactive labdane diterpenoids from Leonurus japonicus†

“…has been used as traditional Chinese herbal medicine for thousands of years. The diverse therapeutic applications of L. japonicus may be attributed to its bioactive constituents, which include terpenoid, [ 1–3 ] alkaloids, [ 4 ] flavonoids, [ 4,5 ] glycosides, [ 6 ] peptides [ 7 ] and volatile oils. [ 8 ] Diterpenoids have become widely studied in recent years.…”