Isolation, structural properties, and bioactivities of polysaccharides from Althaea officinalis Linn.: A review

Xue, Taotao; Ruan, Kaihua; Tang, Zhishu; Duan, Jinao; Xu, Hongbo

doi:10.1016/j.ijbiomac.2023.125098

Cited by 6 publications

(3 citation statements)

References 88 publications

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“…Quantification of polysaccharides by a spectrophotometric method . Determination of polysaccharide content in the extract of eucalypt leaves was carried out by the spectrophotometric method in terms of glucose units after sulfuric-acid hydrolysis for 2.5 h, followed by neutralization and reaction with a 1% aqueous solution of picric acid [ 43 ].…”

Section: Methodsmentioning

confidence: 99%

Eucalypt Extracts Prepared by a No-Waste Method and Their 3D-Printed Dosage Forms Show Antimicrobial and Anti-Inflammatory Activity

Koshovyi,

Komisarenko,

Osolodchenko

et al. 2024

Plants

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The pharmaceutical industry usually utilizes either hydrophobic or hydrophilic substances extracted from raw plant materials to prepare a final product. However, the waste products from the plant material still contain biologically active components with the opposite solubility. The aim of this study was to enhance the comprehensive usability of plant materials by developing a new no-waste extraction method for eucalypt leaves and by investigating the phytochemical and pharmacological properties of eucalypt extracts and their 3D-printed dosage forms. The present extraction method enabled us to prepare both hydrophobic soft extracts and hydrophilic (aqueous) dry extracts. We identified a total of 28 terpenes in the hydrophobic soft extract. In the hydrophilic dry extract, a total of 57 substances were identified, and 26 of them were successfully isolated. The eucalypt extracts studied showed significant antimicrobial activity against Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis, Candida albicans, Corynebacterium diphtheriae gravis, and Corynebacterium diphtheriae mitis. The anti-inflammatory activity of the dry extract was studied using a formalin-induced-edema model in mice. The maximum anti-exudative effect of the dry extract was 61.5% at a dose of 20 mg/kg. Composite gels of polyethylene oxide (PEO) and eucalypt extract were developed, and the key process parameters for semi-solid extrusion (SSE) 3D printing of such gels were verified. The SSE 3D-printed preparations of novel synergistically acting eucalypt extracts could have uses in antimicrobial and anti-inflammatory medicinal applications.

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Section: Methodsmentioning

confidence: 99%

Eucalypt Extracts Prepared by a No-Waste Method and Their 3D-Printed Dosage Forms Show Antimicrobial and Anti-Inflammatory Activity

Koshovyi,

Komisarenko,

Osolodchenko

et al. 2024

Plants

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“…The key structural features of polysaccharides include their monosaccharide composition, molecular weight (M w ), chemical components, and bonding information (55). Different plant parts (i.e., the roots, leaves, stems, or seeds), extraction methods, and isolation and purification steps can lead to variations in polysaccharide structure (56). The structural characteristics of polysaccharides derived from different parts of P. frutescens are summarized in Table 2.…”

Section: Structure Of Perilla Frutescens Polysaccharidesmentioning

confidence: 99%

Recent trends in extraction, purification, structural characterization, and biological activities evaluation of Perilla frutescens (L.) Britton polysaccharide

Zhu,

Guan,

Wang

et al. 2024

Front. Nutr.

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Perilla frutescens (L.) Britton is an annual herb plant of the Perilla genus in the Labiatae family, which is commonly utilized as an edible and medicinal resource. Polysaccharides are among the major components and essential bioactive compounds of P. frutescens, which exhibit a multitude of biological activities, including antioxidant, antitumor, anti-fatigue, immunoregulation, hepatoprotective, anti-inflammatory, and lipid-lowering effects. As a natural carbohydrate, P. frutescens polysaccharide has the potential to be utilized in the development of drugs and functional materials. In this paper, we provide an overview of progress made on the extraction, purification, structural characterization, and bioactivity of polysaccharides from different parts of P. frutescens. The challenges and opportunities for research are discussed, along with the potential development prospects and future areas of focus in the study of P. frutescens polysaccharides.

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“…A. officinalis has been used for a long time as a medicinal plant because of its antiseptic, antioxidant, antimicrobial, anti-inflammatory, and gastroprotective properties (Xue et al, 2023). Marshmallow preparations (powder, aqueous infusion, liquid extract, syrup) are used as an expectorant for catarrhal conditions of the respiratory tract, as well as for diarrhea, acute gastritis Variability of flavonoid content, reducing and antioxidant activity in Althaea officinalis L. hairy roots and enterocolitis.…”

Section: Introductionmentioning

confidence: 99%

Varibility of Flavonoid Content, Reducing and Antioxidant Activity in Althaea officinalis L. Hairy Roots

Bohdanovych

2023

Agrobiodivers Improv Nutr health life Qual

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Althaea officinalis L. is widely used as a medicinal plant due to its antiseptic, antioxidant, antimicrobial, antiinflammatory, and gastroprotective properties. A. officinalis roots contain a great number of secondary metabolites including flavonoids which exert antioxidant and chelating abilities. Flavonoids possess protective effects against several chronic diseases, in particular neurodegeneration and cancer; they have also neuroprotective, hepatoprotective, anti-bacterial, anti-inflammatory, anti-viral, and anti-cancer effects. Tissue cultures of different plant species are a promising source of secondary metabolites with pharmacological activities, and hairy roots are one of the types. Hairy roots are known as fast-growing, genetically stable cultures, effective producers of both biomass and specialized plant metabolites including flavonoids. A. officinalis hairy roots and roots of in vitro cultured control (initial) plants were used in this research to study flavonoid content and some biochemical characteristics (antioxidant activity and ability to reduce iron ions Fe 3+ to Fe 2+ ) of their ethanolic extracts. Two groups of hairy root lines were studied. Hairy roots of one group were obtained as the result of transformation with A4 wild Agrobacterium rhizogenes strain while the second group was initiated by transformation with A. rhizogenes strain carrying human interferon-α2b gene under the control of the sugarbeet root-specific Mll promoter. Among the two groups of hairy root lines no significant differences were detected that could suggest the role of additional genes in the antioxidant status of the hairy roots: in both groups, there were lines with low, medium and high values of the studied parameters. The total flavonoid content correlated with DPPH scavenging activity and reducing capacity. The results of study confirm flavonoid participation in antiradical reactions in A. officinalis hairy root cells.

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Isolation, structural properties, and bioactivities of polysaccharides from Althaea officinalis Linn.: A review

Cited by 6 publications

References 88 publications

Eucalypt Extracts Prepared by a No-Waste Method and Their 3D-Printed Dosage Forms Show Antimicrobial and Anti-Inflammatory Activity

Eucalypt Extracts Prepared by a No-Waste Method and Their 3D-Printed Dosage Forms Show Antimicrobial and Anti-Inflammatory Activity

Recent trends in extraction, purification, structural characterization, and biological activities evaluation of Perilla frutescens (L.) Britton polysaccharide

Varibility of Flavonoid Content, Reducing and Antioxidant Activity in Althaea officinalis L. Hairy Roots

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