Isolation of Trypanosoma rhodesiense from a Bushbuck

Heisch, R. B.; McMahon, J. P.; Manson‐Bahr, Philip

doi:10.1136/bmj.2.5106.1203

Cited by 102 publications

(30 citation statements)

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“…Animals were implicated in the transmission of Tb rhodesiense disease during the 1940s epidemic in Busoga, southeast Uganda 13. The disease re-emerged in Busoga between 1976 and 1983, when 19 974 patients had the disease diagnosed 14.…”

Section: Introductionmentioning

confidence: 99%

Sleeping sickness in Uganda: a thin line between two fatal diseases

Picozzi¹,

Fèvre

Odiit

et al. 2005

BMJ

165

136

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Section: Introductionmentioning

confidence: 99%

Sleeping sickness in Uganda: a thin line between two fatal diseases

Picozzi¹,

Fèvre

Odiit

et al. 2005

BMJ

165

136

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“…This outbreak was considered to be due to T. rhode-siense. Subsequent demonstration of transmission through G. pallidipes supported this view, and`volunteer' studies later con® rmed that the bushbuck harboured trypanosomes which were pathogenic in humans (Heisch et al, 1958). Between the 1940s and the development and exploitation of biochem ical techniques, such as isoenzyme electrophoresis, trypanosomiasis in south± eastern Uganda was considered to be due to both T. gambiense and T. rhodesiense.…”

mentioning

confidence: 99%

Human African trypanosomiasis south - eastern Uganda: clinical and isoenzyme profiles in diversity

Smith

Bailey

1997

Annals of Tropical Medicine And Parasitology

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The spectrum of clinical manifestations of trypanosomiasis in south-eastern Uganda is extremely wide. Isoenzyme characterization of trypanosome strains isolated in this area during recent epidemics of sleeping sickness has shown that particular clinical features of the disease can be related to the zymodeme of the causative parasite. For example, B17, part of the 'busoga' group of isolates and a zymodeme identified from central areas of Busoga during outbreaks of sleeping sickness, is associated with severe early features and a high frequency of presentation with a chancre. Isolates belonging to the 'zambezi' group, most of which came from areas close to the lake shores or close to the River Nile, were more heterogenous and were associated with significantly different clinical features: a more chronic, prolonged illness; more frequent presentation with meningo-encephalitis, and less frequent chancres. The clinical spectrum of infection associated with the parasites currently in circulation indicates that the previous endemicity and the early epidemics could be explained on the basis of existing zymodemes.

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“…The existence of a wild-animal reservoir for T. b. rhodesiense has long been demonstrated (125). For T. b. gambiense, both wild and domestic animals have also been shown to be capable of acting as reservoir hosts (73,233).…”

Section: Parasites That Preferentially Involve the Myocardium Or Causmentioning

confidence: 99%

Cardiac Involvement with Parasitic Infections

et al. 2010

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SUMMARY Parasitic infections previously seen only in developing tropical settings can be currently diagnosed worldwide due to travel and population migration. Some parasites may directly or indirectly affect various anatomical structures of the heart, with infections manifested as myocarditis, pericarditis, pancarditis, or pulmonary hypertension. Thus, it has become quite relevant for clinicians in developed settings to consider parasitic infections in the differential diagnosis of myocardial and pericardial disease anywhere around the globe. Chagas' disease is by far the most important parasitic infection of the heart and one that it is currently considered a global parasitic infection due to the growing migration of populations from areas where these infections are highly endemic to settings where they are not endemic. Current advances in the treatment of African trypanosomiasis offer hope to prevent not only the neurological complications but also the frequently identified cardiac manifestations of this life-threatening parasitic infection. The lack of effective vaccines, optimal chemoprophylaxis, or evidence-based pharmacological therapies to control many of the parasitic diseases of the heart, in particular Chagas' disease, makes this disease one of the most important public health challenges of our time.

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Isolation of Trypanosoma rhodesiense from a Bushbuck

Cited by 102 publications

References 1 publication

Sleeping sickness in Uganda: a thin line between two fatal diseases

Sleeping sickness in Uganda: a thin line between two fatal diseases

Human African trypanosomiasis south - eastern Uganda: clinical and isoenzyme profiles in diversity

Cardiac Involvement with Parasitic Infections

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