Isolation of the human placenta receptor for epidermal growth factor-urogastrone

Hock, Rick S.; Nexø, Ebba; Hollenberg, Morley D.

doi:10.1038/277403a0

Cited by 86 publications

(36 citation statements)

References 24 publications

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“…In vivo, EGF elicits precocious tooth eruption and eyelid opening in rodents, accelerates lung maturation in lambs and reduces gastric acid secretion in man (4-9). EGF binds to specific plasma membrane receptors that are found in many tissues and significant EGF binding to embryonal tissues has been reported (7,(10)(11)(12)(13)(14) An early indication of a close relation between thyroid hormones and EGF was found by Hamburgh et al (1 5) who showed that the delay of eyelid opening and tooth eruption observed in hypothyroid animals was reversed by either thyroxine or EGF administration. Further studies suggest that synthesis of both EGF and its receptor protein are influenced by thyroid hormones (3,4,12,(16)(17)(18)(19)(20).…”

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confidence: 90%

“…In vivo, EGF elicits precocious tooth eruption and eyelid opening in rodents, accelerates lung maturation in lambs and reduces gastric acid secretion in man (4)(5)(6)(7)(8)(9). EGF binds to specific plasma membrane receptors that are found in many tissues and significant EGF binding to embryonal tissues has been reported (7,(10)(11)(12)(13)(14).…”

Section: The Affinity Of Egf Receptor Binding Initially Wasmentioning

confidence: 99%

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Neonatal Hyperthyroidism Alters Hepatic Epidermal Growth Factor Receptor Ontogeny in Mice

et al. 1988

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ABSTRACT. Epidermal growth factor (EGF) liver receptor ontogeny and somatic growth were studied in mice from day 7 to day 70 postnatally to assess long-term effects of short-term postnatal thyroxine treatment. The mice were given 0.4 pg thyroxinelg body weightlday for the 1st wk of life. EGF receptor binding in liver tissue was studied on days 7, 15, 20, 30, and 70 postnatally. Treated animals had accelerated eyelid opening and tooth eruption, and permanent growth retardation was obvious from the second week of life. Hepatic EGF receptor-binding capacity increased markedly in control mice with increasing age in contrast to a very slow increase in treated mice, making the difference statistically significant (P < 0.01) from day 30. The affinity of EGF receptor binding initially was similar in the two groups of animals (1.09 x lo9 M-' and 1.02 x lo9 M-') and increased by day 30 in controls (2.57 x lo9 M-I), an increase that was not observed in treated animals either at day 30 or 70. These results suggest a sensitive period of imprinting during the first 7 days postnatally, a period when thyroxine can exert a permanent effect on later growth and later hepatic EGF receptor number. (Pediatr Res 23: 557-560, 1988) Abbreviations EGF, epidermal growth factor T4, thyroxine TSH, thyroid-stimulating hormone Thyroid hormones are necessary for postnatal growth and development in rodents as in humans although the mechanism of the thyroid hormone effect is not entirely clear (1). Recent studies suggest that thyroid hormone interaction with specific growth factors may be important for normal postnatal growth and development (2). An interaction with the growth hormonesomatomedin axis has been described (2). Several other growth factors have been studied, but to date the interaction between thyroid hormones and EGF is the best characterized (3,4). EGF is a polypeptide (mouse EGF mol. wt. 6045) first described in extracts from mouse submandibular glands (5-7). In vivo, EGF elicits precocious tooth eruption and eyelid opening in rodents, accelerates lung maturation in lambs and reduces gastric acid secretion in man (4-9). EGF binds to specific plasma membrane receptors that are found in many tissues and significant EGF binding to embryonal tissues has been reported (7,(10)(11)(12)(13)(14) An early indication of a close relation between thyroid hormones and EGF was found by Hamburgh et al. (1 5) who showed that the delay of eyelid opening and tooth eruption observed in hypothyroid animals was reversed by either thyroxine or EGF administration. Further studies suggest that synthesis of both EGF and its receptor protein are influenced by thyroid hormones (3,4,12,(16)(17)(18)(19)(20). Recent studies of early postnatal T4 treatment (0-6 days) of newborn mice have shown a prolonged effect of the T4 on tissue and urine EGF levels and a prolonged effect on growth (21). This effect was not observed in mice treated only during the 2nd wk of life (2 1). The present study was undertaken to relate the disturbances in somatic growth to the postn...

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confidence: 90%

Section: The Affinity Of Egf Receptor Binding Initially Wasmentioning

confidence: 99%

Neonatal Hyperthyroidism Alters Hepatic Epidermal Growth Factor Receptor Ontogeny in Mice

et al. 1988

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“…The EGFR was initially identified in cell cultures [Haigler et al, 1978], but, subsequently, it was shown to be abundant in both placenta and liver [Sahyoun et al, 1978;Hock et al, 1979]. Our data show the highest amount of mRNA coding for EGFR is in the liver with relatively low levels ofHER2 and no HER4 or EGF mRNA.…”

Section: Discussionmentioning

confidence: 68%

Effects of Long-Term Cobalamin Treatment on the Expression of the Epidermal Growth Factor System in Mouse Kidney

Mutti¹,

Kristensen²,

Lildballe³

et al. 2014

UROL

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Background: The epidermal growth factor (EGF) system plays an important role in the development and function of the kidneys. Studies have suggested this system to protect against acute renal injury and to prevent the progression of chronic kidney disease. We have demonstrated that cobalamin (Cbl) modulates the expression of the EGF system in mouse spinal cord. Here, we explore the effects of Cbl treatment on the mouse kidney expression of members of the EGF system comparing these with the expression in the submaxillary gland and liver. Methods: Following four weeks of administrating different doses of Cbl, we analysed kidney, submaxillary gland, and liver mRNA levels of the four EGF system receptors and the activating ligands EGF and heparin-binding EGF-like growth factor using quantitative reverse transcription-PCR. In addition, we analysed mRNA expression of the renal tubular injury markers, kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin. Results: In controls, kidney expression of EGF system receptors and ligands was similar to or more than twice the levels in the submaxillary gland. A relatively high expression of the EGF receptor was observed in liver tissue, but only low or no expression of other EGF related molecules. Treatment with Cbl decreased expression of the EGF system in the kidneys in a dose-dependent manner, while no or little change was observed in other organs. No alterations were observed in the markers of kidney tubular injury after Cbl administration. Conclusions: Our results show modulation of the renal EGF system expression in mice following long term Cbl administration. This may have implications for prevention of progressive kidney disease. In addition, differences in the expression of the EGF receptors and ligands in liver, submaxillary gland and kidney were demonstrated.

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“…Interest in these particular hormones/factors as modulators of placental metabolism has been fuelled, in part, by the demonstration of specific, membrane-associated receptors in the human placenta (25,36,38,43,46,48,54,57), two of which (for insulin and EGF-URO) have been partially purified (26,28,60). Placental cytosolic binding proteins for some of the IGFs have also been described (7,22).…”

Section: Speculationmentioning

confidence: 99%

Ontogeny of Growth Factor Receptors in the Human Placenta

et al. 1982

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Isolation of the human placenta receptor for epidermal growth factor-urogastrone

Cited by 86 publications

References 24 publications

Neonatal Hyperthyroidism Alters Hepatic Epidermal Growth Factor Receptor Ontogeny in Mice

Neonatal Hyperthyroidism Alters Hepatic Epidermal Growth Factor Receptor Ontogeny in Mice

Effects of Long-Term Cobalamin Treatment on the Expression of the Epidermal Growth Factor System in Mouse Kidney

Ontogeny of Growth Factor Receptors in the Human Placenta

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