Isolation of Tetra-, Penta-, Hexa- and Heptaacyl Glycerides from Stigmas of<i>Nicotiana tabacum</i>

Matsuzaki, Toshiake; Koiwai, Akira; Kawashima, Nobumaro

doi:10.1080/00021369.1983.10865578

Cited by 1 publication

(1 citation statement)

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“…This suggests that the sebum spectrum also contains tetra-, penta-, and hexa-acyl glycerides connected by ester linking additional C 12‑18 H 24‑32 O 2 moieties. Such compounds have previously been identified in plants but not to date in humans.…”

Section: Resultsmentioning

confidence: 96%

Paper Spray Ionization Ion Mobility Mass Spectrometry of Sebum Classifies Biomarker Classes for the Diagnosis of Parkinson’s Disease

Sarkar

Sinclair

Lim

et al. 2022

JACS Au

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Parkinson’s disease (PD) is the second most common neurodegenerative disorder, and identification of robust biomarkers to complement clinical diagnosis will accelerate treatment options. Here, we demonstrate the use of direct infusion of sebum from skin swabs using paper spray ionization coupled with ion mobility mass spectrometry (PS-IM-MS) to determine the regulation of molecular classes of lipids in sebum that are diagnostic of PD. A PS-IM-MS method for sebum samples that takes 3 min per swab was developed and optimized. The method was applied to skin swabs collected from 150 people and elucidates ∼4200 features from each subject, which were independently analyzed. The data included high molecular weight lipids (>600 Da) that differ significantly in the sebum of people with PD. Putative metabolite annotations of several lipid classes, predominantly triglycerides and larger acyl glycerides, were obtained using accurate mass, tandem mass spectrometry, and collision cross section measurements.

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Section: Resultsmentioning

confidence: 96%