Isolation of Swine Influenza Virus from Autopsy Lung Tissue of Man

Smith, Thomas F.; Burgert, E. Omer; Dowdle, Walter R.; Noble, Gary R.; Campbell, Robert J.; Scoy, Robert E. Van

doi:10.1056/nejm197603252941308

Cited by 95 publications

(51 citation statements)

References 6 publications

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“…Swine influenza virus infections in humans have been reported throughout the world, with the first isolation of a swine influenza virus from a human in 1974 although influenza virus was first isolated from a pig in 1930 (27,31,32). Despite this, there have been few studies documenting the pathology associated with swine influenza virus isolates in ferrets, the animal model for humans.…”

Section: Discussionmentioning

confidence: 99%

Comparative Pathology in Ferrets Infected with H1N1 Influenza A Viruses Isolated from Different Hosts

Smith

Nagy

Driskell

et al. 2011

J Virol

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Virus replication and pulmonary disease pathogenesis in ferrets following) were compared. Nasal wash virus titers were similar for Ncal99 and Sw30, with peak virus titers of 10 5.1 50% tissue culture infectious doses (TCID 50 )/ml and 10 5.5 TCID 50 /ml occurring at day 3 postinfection (p.i.), respectively. The mean peak titer for CA09 also occurred at day 3 p.i. but was higher (10 7 TCID 50 /ml). In contrast, the peak virus titers (10 3.6 to 10 4.3 TCID 50 /ml) for Mal08 were delayed, occurring between days 5 and 7 p.i. Disease pathogenesis was characterized by microscopic lesions in the nasal turbinates and lungs of all ferrets; however, Sw30 infection was associated with severe bronchointerstitial pneumonia. The results demonstrate that although CA09 is highly transmissible in the human population and replicates well in the ferret model, it causes modest disease compared to other H1N1 viruses, particularly Sw30 infection.

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Section: Discussionmentioning

confidence: 99%

Comparative Pathology in Ferrets Infected with H1N1 Influenza A Viruses Isolated from Different Hosts

Smith

Nagy

Driskell

et al. 2011

J Virol

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“…This virus is antigenically conserved, genetically closely related to the 1918 "Spanish flu" strain, and prevalent throughout the major pig populations of the world. Zoonotic transmission of H1N1 viruses from pigs has been described (43) and in some cases these infections proved to be fatal (44). The other swine strain, Swine Tr, is an isolate that arose from reassortment events among recent human H3N2, classical swine H1N1, and avian influenza A viruses; the hemagglutinin gene was derived from a human H3N2 virus that was circulating in 1995 (45).…”

Section: Ha By Swine Iavs Is Preferentially Inhibited By Sp-d But Depmentioning

confidence: 99%

Porcine Pulmonary Collectins Show Distinct Interactions with Influenza A Viruses: Role of theN-Linked Oligosaccharides in the Carbohydrate Recognition Domain

Eijk¹,

White

Crouch

et al. 2003

The Journal of Immunology

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Influenza A virus (IAV) infections are a major cause of respiratory disease of humans and animals. Pigs can serve as important intermediate hosts for transmission of avian IAV strains to humans, and for the generation of reassortant strains; this may result in the appearance of new pandemic IAV strains in humans. We have studied the role of the porcine lung collectins surfactant proteins D and A (pSP-D and pSP-A), two important components of the innate immune response against IAV. Hemagglutination inhibition assays revealed that both pSP-D and pSP-A display substantially greater inhibitory activity against IAV strains isolated from human, swine, and horse, than lung collectins from other animal species. The more potent activity of pSP-D results from interactions mediated by the asparagine-linked oligosaccharide located in the carbohydrate recognition domain of pSP-D, which is absent in SP-Ds from other species characterized to date. Presence of this sialylated oligosaccharide moiety enhances the anti-influenza activity of pSP-D, as demonstrated by assays of viral aggregation, inhibition of infectivity, and neutrophil response to IAV. The greater hemagglutination inhibitory activity of pSP-A is due to porcine-specific structural features of the conserved asparagine-linked oligosaccharide in the carbohydrate recognition domain of SP-A. A more efficient lung collectin-mediated immune response against IAV in pigs may play a role in providing conditions by which pigs can act as “mixing vessel” hosts that can lead to the production of reassortant, pandemic strains of IAV.

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“…The first isolation of the swine influenza virus from a human occurred in 1974 (1), confirming the speculation that swine-origin influenza viruses could infect humans. Since 1975, sporadic human infections with swine viruses and a small outbreak have been documented (2)(3)(4)(5)(6)(7)(8)(9).…”

mentioning

confidence: 65%

Chest Radiographic Findings of Novel Swine-Origin Influenza A (H1N1) Virus Infection in Children

Bae

Hong

Chang

et al. 2011

J Korean Soc Radiol

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Purpose: To analyze chest radiographic findings in children infected with laboratoryconfirmed novel swine-origin influenza A (H1N1) virus. Materials and Methods: Three hundred seventy-two out of 2,014 children with laboratory confirmed H1N1 infection and who also underwent a chest radiograph from September to November 2009 were enrolled in this study. Patients were divided into in-patients, out-patients, and patients with co-infections and further subdivided into with underlying disease and without underlying disease as well as age (<2 years old, 2-5 years, 5-10 years, 10-18 years old). The initial radiographs were evaluated for radiographic findings and the anatomic distribution of abnormalities. Results: The initial radiographs were abnormal in 154 (41.39%) patients. The predominant radiographic findings were peribronchial wall opacity found in 85 (22.84%) patients and hyperinflation observed in 69 (18.54%) patients. Further, 75 (71.42%) patients exhibited central predominance and the right lower lung zone was also commonly involved. There were statistically significant differences in the radiological findings between in-patient and out-patient groups. However, there were no significant differences in the radiographic findings between in-patients and the co-infection group with respect the presence of underlying disease and age. Conclusion: Initial radiographs of children with laboratory confirmed H1N1 virus were abnormal in 41.39% of cases. The common radiographic findings included peribronchial opacities, hyperinflation, lower lung zonal distribution, and central predominance.

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Isolation of Swine Influenza Virus from Autopsy Lung Tissue of Man

Cited by 95 publications

References 6 publications

Comparative Pathology in Ferrets Infected with H1N1 Influenza A Viruses Isolated from Different Hosts

Comparative Pathology in Ferrets Infected with H1N1 Influenza A Viruses Isolated from Different Hosts

Porcine Pulmonary Collectins Show Distinct Interactions with Influenza A Viruses: Role of theN-Linked Oligosaccharides in the Carbohydrate Recognition Domain

Chest Radiographic Findings of Novel Swine-Origin Influenza A (H1N1) Virus Infection in Children

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