Isolation of Sesquiterpene Lactones and the Antioxidant and Anticancer Activities of Crude Extracts from Cyanthillium cinereum

Traditional Uses, Phytochemistry, and Pharmacological Activities of Vernonia cinerea (L.) Less.: An Updated Review

“…Additionally, hirsutinolide-type sesquiterpenoids from V. cinerea exhibited IC 50 values against human prostate (PC-3) and LNCaP cancer cell lines ranging from 2.2 ± 0.4 to 8.5 ± 0.7 µM and 3.0 ± 0.7 to 10.5 ± 1.1 µM, respectively, thus indicating substantial antiprostate cancer activity [44]. Also, compound 11 showed anticancer activity with IC 50 values of 12.5 and 10.4 µg/mL against human renal cell carcinoma (786-O cell line) cells after 48 and 72 h, respectively [74].…”

“…Seven flavonoids (70)(71)(72)(73)(74)(75)(76) are known to be present in V. cinerea (Figure 5). Among them, most belong to the flavone and flavonol groups.…”

“…Employing various chemical degradations and NMR spectroscopy analysis, the new compound was identified as 5,7,4 (76), which exhibited moderate antiviral effects. In addition, several other flavonoids and flavonoid glycosides, including luteolin 4 ′ -O-glucoside (71), luteolin 7-O-glucoside (72), quercetin 3-O-β-D-glucopyranoside (73), and apigenin (74), have been found in the roots of V. cinerea [27,45,62,63].…”

Natural products targeting inflammation-related metabolic disorders: A comprehensive review

“… •Compound 1 increased ROS production in 786-O cells in a time-dependent manner but gradually was weaker after incubation for 2 h. •Compound 1 significantly increased LDH release in a time/concentration-dependent manner. [ 60 ] 14 Tourneuxia variifolia Ethyl acetate (EtOAc) and n-butanol (n- BuOH) extracts Inhibit the activity of HeLa cells An in vitro study using human cervical adenocarcinoma (HeLa) cell line •EtOAc and n-BuOH extracts contained high quantities of phenolic compounds. •The EtOAc extract showed potent anticancer activity with IC50 of 46.797 ± 0.060 mg/mL.…”