Isolation of quinone reductase (QR) inducing agents from ginger rhizome and their in vitro anti-inflammatory activity

Feng, Li; Wang, Yongli; Parkin, Kirk L.; Nitteranon, Viriya; Liang, Jin; Yang, Wenjian; Li, Ying; Zhang, Guodong; Hu, Qiuhui

doi:10.1016/j.foodres.2011.04.010

Cited by 18 publications

(14 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Activation of phase II detoxification enzymes (GST, GR and GSH) and inhibition of phase I enzymes were noticed in orally administered [6]‐shogaol. Similarly, previous studies reported that ginger‐derived structural analogue such as [6]‐gingerol, [6]‐dehydroshogaol possibly induce phase II detoxification enzymes in different experimental models (Li et al ., ; Zhang et al ., ).…”

Section: Discussionmentioning

confidence: 99%

“…Previous study clearly shown that natural occurring phytochemical can able to enhance phase II drug detoxification enzymes and elevate antioxidant thereby, inhibit carcinogenesis (Kavitha et al, 2013). Overproduction of toxins may neutralize phase II enzymes through the conjugation process, resulting in decreased oxidative (Li et al, 2011;Zhang et al, 2013). Alteration of oncogenes and tumour suppressor genes expression is associated with apoptosis and/or tumour development (Wong, 2011).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

[6]‐Shogaol, a Novel Chemopreventor in 7,12‐Dimethylbenz[a]anthracene‐induced Hamster Buccal Pouch Carcinogenesis

Suresh

Annamalai

2016

Phytotherapy Research

View full text Add to dashboard Cite

Oral cancer is a major cause of morbidity and mortality in developing countries. Despite advances in chemotherapy for the cancer management, the survival rate has not yet been improved. Dietary nutrient has been receiving a lot of attention and interest in the chemotherapeutic development. [6]-Shogaol is a major bioactive compound identified in ginger that possesses many pharmacological properties. The aim of the present study is to investigate the effect of [6]-shogaol on 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch (HBP) carcinogenesis. Oral squamous cell carcinoma induced in HBP by painting with 0.5% 7,12-dimethylbenz(a)anthracene (DMBA), thrice in a week for 16 weeks. We observed 100% tumour incidence, decreased levels of lipid peroxidation, antioxidant, and phase II detoxification enzymes (GST, GR and GSH) in DMBA-induced hamsters. Further, enhanced activity of phase I enzymes (cytochrome p450 and b5) and over-expression of mutant p53, Bcl-2 and decreased expression of wild type p53 and Bax were noticed in DMBA-induced hamsters. Our results indicated that [6]-shogaol (10, 20 and 40 mg/kg body weight) treated with DMBA-painted hamsters, considerably reversed tumour incidence, improved antioxidant status, phase II detoxification enzymes, and also inhibit lipid peroxidation and phase I enzymes. Moreover, [6]-shogaol inhibits mutant p53 and Bcl-2 expression and significantly restored normal p53, Bax levels. Thus, we concluded that [6]-shogaol prevents DMBA-induced HBP carcinogenesis through its antioxidant as well as modulating apoptotic signals.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

[6]‐Shogaol, a Novel Chemopreventor in 7,12‐Dimethylbenz[a]anthracene‐induced Hamster Buccal Pouch Carcinogenesis

Suresh

Annamalai

2016

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…Ginger extracts, especially gingerol and shogaol, exhibit antiallergenic effects by inhibiting the release of inflammatory mediators and b-hexosaminidase from RHL-2H cells (tumour analogue of mast cells) without causing cytotoxicity (Chen et al, 2009). Our previous study also showed, for the first time that 1-dehydro-[6]-gingerdione and 6-dehydroshogaol exhibited potent quinone reductaseinducing activity in murine hepatoma Hepa1c1c7 cells (Li et al, 2011). However, to the best of our knowledge, there appear to be limited investigations focusing on the structure-activity relationship or on the mechanisms of anti-inflammatory actions of ginger compounds.…”

Section: Introductionmentioning

confidence: 88%

“…Hexahydrocurcumin, 6-dehydroshogaol, 1-dehydro-[6]-gingerdione and 6-shogaol were prepared as reported previously in our lab (Li et al, 2011). Briefly, approximately 7.5 kg of fresh ginger rhizome ( Z. officinale) were transversely sliced into $1-2 mm pieces and refluxed with 10 l of ethanol for 4 h. The resulting aqueous-ethanol extract was concentrated, and then 1 l of ethyl acetate (EtOAc) was added to afford a phase-partitioning of extracted material.…”

Section: Preparation Of Hexahydrocurcumin 6-shogaol 1-dehydro-[6]-gmentioning

confidence: 99%

In vitro antioxidant and anti-inflammatory activities of 1-dehydro-[6]-gingerdione, 6-shogaol, 6-dehydroshogaol and hexahydrocurcumin

Li¹,

Nitteranon²,

Tang³

et al. 2012

Food Chemistry

Self Cite

View full text Add to dashboard Cite

“…A few other classes of secondary metabolites have been shown to induce QR1 activity such as triterpenes [7], flavonoids [8,9,10,11], labdane diterpenes [12], and other small molecular weight phenolic compounds [4,13], though the majority of these structures exhibit moderate to weak CD values when compared to their stilbene, flavonoid, and β-carboline counterparts.…”

Section: Introductionmentioning

confidence: 99%

Potential Chemopreventive Activity of a New Macrolide Antibiotic from a Marine-Derived Micromonospora sp.

et al. 2013

View full text Add to dashboard Cite

Agents capable of inducing phase II enzymes such as quinone reductase 1 (QR1) are known to have the potential of mediating cancer chemopreventive activity. As part of a program to discover novel phase II enzyme-inducing molecules, we identified a marine-derived actinomycete strain (CNJ-878) that exhibited activity with cultured Hepa 1c1c7 cells. Based on this activity, a new macrolide, juvenimicin C (1), as well as 5-O-α-l-rhamnosyltylactone (2), were isolated from the culture broth of a Micromonospora sp. Compound 1 enhanced QR1 enzyme activity and glutathione levels by two-fold with CD values of 10.1 and 27.7 μM, respectively. In addition, glutathione reductase and glutathione peroxidase activities were elevated. This is the first reported member of the macrolide class of antibiotics found to mediate these responses.

show abstract

Isolation of quinone reductase (QR) inducing agents from ginger rhizome and their in vitro anti-inflammatory activity

Cited by 18 publications

References 37 publications

[6]‐Shogaol, a Novel Chemopreventor in 7,12‐Dimethylbenz[a]anthracene‐induced Hamster Buccal Pouch Carcinogenesis

[6]‐Shogaol, a Novel Chemopreventor in 7,12‐Dimethylbenz[a]anthracene‐induced Hamster Buccal Pouch Carcinogenesis

In vitro antioxidant and anti-inflammatory activities of 1-dehydro-[6]-gingerdione, 6-shogaol, 6-dehydroshogaol and hexahydrocurcumin

Potential Chemopreventive Activity of a New Macrolide Antibiotic from a Marine-Derived Micromonospora sp.

Contact Info

Product

Resources

About