Isolation of panleucopaenia virus from lions

Studdert, M. J.; Kelly, CM; Harrigan, KE

doi:10.1136/vr.93.6.156

Cited by 8 publications

(6 citation statements)

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“…Clinical cases associated with FPV infections in wild cats (Chappuis and Lernould, 1987) have been reported. A FPV virus was isolated from the spleen of a 9-mo-old leopard (Panthera pardus, Johnson 1964), and later FPV was isolated from a lion (Studdert et al, 1973), disproving the previously suggested natural resistance of lions. The agent causing feline ataxia was identified as FPV by Johnson et al (1967).…”

Section: Feline Panleukopenia Virus (Fpv)mentioning

confidence: 92%

Parvovirus Infections in Wild Carnivores

Steinel

Parrish

Bloom

et al. 2001

Journal of Wildlife Diseases

192

181

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Various parvoviruses infect carnivores and can cause disease. In this review article the knowledge about infections of free-ranging or captive carnivores with the feline parvoviruses, feline panleukopenia virus, and canine parvovirus, including the antigenic types CPV-2a and -2b, as well as Aleutian disease of mink virus and minute virus of canines are summarized. Particular emphasis is placed on description of the evolution of canine parvovirus which apparently involved wild carnivore hosts.

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Section: Feline Panleukopenia Virus (Fpv)mentioning

confidence: 92%

Parvovirus Infections in Wild Carnivores

Steinel

Parrish

Bloom

et al. 2001

Journal of Wildlife Diseases

192

181

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“…VP2, the major structural protein of the viral capsid, determines the pathogenicity, tissue tropism and host ranges of this virus subgroup [4,5]. FPLV was originally identified in domestic cats [6] and later on other large felids, such as tigers, panthers, cheetahs and lions [2,7,8,9,10,11,12]. Canine parvovirus (CPV-2) was detected for the first time in 1978, possibly emerging from a FPLV like-virus [13].…”

Section: Introductionmentioning

confidence: 99%

Snapshot of Viral Infections in Wild Carnivores Reveals Ubiquity of Parvovirus and Susceptibility of Egyptian Mongoose to Feline Panleukopenia Virus

et al. 2013

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The exposure of wild carnivores to viral pathogens, with emphasis on parvovirus (CPV/FPLV), was assessed based on the molecular screening of tissue samples from 128 hunted or accidentally road-killed animals collected in Portugal from 2008 to 2011, including Egyptian mongoose (Herpestes ichneumon, n = 99), red fox (Vulpes vulpes, n = 19), stone marten (Martes foina, n = 3), common genet (Genetta genetta, n = 3) and Eurasian badger (Meles meles, n = 4). A high prevalence of parvovirus DNA (63%) was detected among all surveyed species, particularly in mongooses (58%) and red foxes (79%), along with the presence of CPV/FPLV circulating antibodies that were identified in 90% of a subset of parvovirus-DNA positive samples. Most specimens were extensively autolysed, restricting macro and microscopic investigations for lesion evaluation. Whenever possible to examine, signs of active disease were not present, supporting the hypothesis that the parvovirus vp2 gene fragments detected by real-time PCR possibly correspond to viral DNA reminiscent from previous infections. The molecular characterization of viruses, based on the analysis of the complete or partial sequence of the vp2 gene, allowed typifying three viral strains of mongoose and four red fox’s as feline panleukopenia virus (FPLV) and one stone marten’s as newCPV-2b type. The genetic similarity found between the FPLV viruses from free-ranging and captive wild species originated in Portugal and publicly available comparable sequences, suggests a closer genetic relatedness among FPLV circulating in Portugal.Although the clinical and epidemiological significance of infection could not be established, this study evidences that exposure of sympatric wild carnivores to parvovirus is common and geographically widespread, potentially carrying a risk to susceptible populations at the wildlife-domestic interface and to threatened species, such as the wildcat (Felis silvestris) and the critically endangered Iberian lynx (Lynx pardinus).

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“…In 1964, Johnson reported the isolation of feline panleukopenia virus from the spleen of a leopard cub born at Bristol Zoo (20). Subsequently, FPV was isolated from dead captive lions, panthers, snow leopards, and tigers (46,47). The majority of the free-ranging mountain lions in California (93%) and the lions in Kruger National Park (84%) had antibodies to FPV (36,43), while none of the free-ranging lions in Etosha National Park did (44).…”

mentioning

confidence: 99%

Prevalence of antibodies to feline parvovirus, calicivirus, herpesvirus, coronavirus, and immunodeficiency virus and of feline leukemia virus antigen and the interrelationship of these viral infections in free-ranging lions in east Africa

Hofmann‐Lehmann

Fehr

Grob

et al. 1996

Clin Diagn Lab Immunol

106

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While viral infections and their impact are well studied in domestic cats, only limited information is available on their occurrence in free-ranging lions. The goals of the present study were (i) to investigate the prevalence of antibodies to feline calicivirus (FCV), herpesvirus (FHV), coronavirus (FCoV), parvovirus (FPV), and immunodeficiency virus (FIV) and of feline leukemia virus (FeLV) antigen in 311 serum samples collected between 1984 and 1991 from lions inhabiting Tanzania's national parks and (ii) to evaluate the possible biological importance and the interrelationship of these viral infections. Antibodies to FCV, never reported previously in free-ranging lions, were detected in 70% of the sera. In addition, a much higher prevalence of antibodies to FCoV (57%) was found than was previously reported in Etosha National Park and Kruger National Park. Titers ranged from 25 to 400. FeLV antigen was not detectable in any of the serum samples. FCoV, FCV, FHV, and FIV were endemic in the Serengeti, while a transient elevation of FPV titers pointed to an outbreak of FPV infection between 1985 and 1987. Antibody titers to FPV and FCV were highly prevalent in the Serengeti (FPV, 75%; FCV, 67%) but not in Ngorongoro Crater (FPV, 27%; FCV, 2%). These differences could be explained by the different habitats and biological histories of the two populations and by the well-documented absence of immigration of lions from the Serengeti plains into Ngorongoro Crater after 1965. These observations indicate that, although the pathological potential of these viral infections seemed not to be very high in free-ranging lions, relocation of seropositive animals by humans to seronegative lion populations must be considered very carefully.

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Isolation of panleucopaenia virus from lions

Cited by 8 publications

References 0 publications

Parvovirus Infections in Wild Carnivores

Parvovirus Infections in Wild Carnivores

Snapshot of Viral Infections in Wild Carnivores Reveals Ubiquity of Parvovirus and Susceptibility of Egyptian Mongoose to Feline Panleukopenia Virus

Prevalence of antibodies to feline parvovirus, calicivirus, herpesvirus, coronavirus, and immunodeficiency virus and of feline leukemia virus antigen and the interrelationship of these viral infections in free-ranging lions in east Africa

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