Isolation of oleanolic acid and ursolic acid from Thymus vulgaris, L.

Rowe, Edward J.; Orr, Jack E.; Uhl, Arthur H.; Parks, Lloyd M.

doi:10.1002/jps.3030380303

Cited by 17 publications

(4 citation statements)

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“…Thyme contains also tannins, caffeic acid 1.8%, chlorogenic acid 1.1% (Barbawski 1965), oleanolic acid 0.6%, ursolic acid 1.7% (Rowe 1949), saponins (Garcia Marquina 1949, thymol and carvacrol glycosides (Skopp and H6rster 1976), luteolin (Awe et a!. 1959), apigenin, apigenin-7-~-glucoside, luteolin-7-~ glucoside, luteolin-7-~-diglucoside, (Olechnowicz-St~pien and Lamer-Zarawska 1975), hydroxy-6-luteolin (Adzet and Martinez-Verges 1980), and three methylated flavones isolated by van den Broucke et al (1982): 5,4'-dihydroxy-6,7,8,3'-tetramethoxyfla vone (8-methoxy-cirsilineol), 5,4' -dihydroxy-6,7,3' -trimethoxyflavone (cirsilineol), and 5,6,4' -trihydroxy-7,8,3' -trimethoxyflavone (thymonine) (Fig.…”

Section: Chemical Componentsmentioning

confidence: 99%

Micropropagation of Thyme (Thymus vulgaris L.)

Furmanowa¹,

Olszowska

1992

High-Tech and Micropropagation III

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Section: Chemical Componentsmentioning

confidence: 99%

Micropropagation of Thyme (Thymus vulgaris L.)

Furmanowa¹,

Olszowska

1992

High-Tech and Micropropagation III

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“…The present study was commissioned to evaluate the safety of ursolic acid, berberine and piceid as potential ingredients of poultry feed. In 1920 a pentacyclic triterpenoid compound was identified in peels of fruits, such as the epicuticular waxes of apples, as well as in herbs and spices including rosemary and thyme [1,2]. This compound is known as ursolic acid (also referred to as urson, prunol, malol, or 3-beta-3-hydroxy-urs-12-ene-28-oicacid).…”

Section: Introductionmentioning

confidence: 99%

A Large Scale Safety Study to Investigate the Inclusion of Phytogenic Compounds in Broiler Chicken Feed

Xiao¹

2018

APDV

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Background: Phytochemical agents derived from traditional plants have been used in various countries as dietary components. The poultry industry is looking at alternatives to current poultry feed ingredients and phytogenic compounds are one group of alternatives. In the "western" world, even though some agents have not been used in animal husbandry, several phytogenic compounds have been used in human pharmaceutical or nutraceutical products. The lack of safety data has prevented the use of phytogenic compounds in poultry feed. The present study focuses on the general health of broiler chickens during and after administration of feed containing the natural phytogenic compounds, berberine, ursolic acid and piceid, administered in different concentrations. Methods and Results: 64 pens each containing 20 male broiler chickens were used in this study. The treatments were divided into eight groups each of which were randomly allocated to eight replicate pens. The study was carried out by an independent contractor, Southern Poultry Feed and Research, Inc. on behalf of the authors. The contractor conducted a randomization procedure for pen assignment, and subsequently conducted the safety study by feeding birds for 42 days. Birds were weighed on days 21, 35 and 42. The food intake was quantified allowing estimation of feed conversion ratio. On day 42 birds were euthanized for analysis of liver pathology. At all concentration tested all three agents tested were found to have no adverse effects on the birds and did not significantly affect feed conversion ratio when included in poultry feed. Conclusion:This substantial study suggests that berberine, ursolic acid or piceid can be included safely in poultry feed up to the highest concentrations tested in this study, i.e. 0.3g berberine, 0.05g ursolic acid, or 0.5g piceid per kg poultry feed. Materials and Methods Source of materials and animalsCompounds: Phytogenic compounds berberine chloride, ursolic acid and piceid were sourced from JiaHe (Shaanxi, China).

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“…Ursolic acid ((3β)-3-hydroxyurs-12-en-28-oic acid) (UA) is a pentacyclic triterpenoid compound derived from Cornus officinalis (Cornaceae) [197]. In PC-3 cells, UA evokes apoptosis via extrinsic and intrinsic apoptotic pathways while it confines cell invasion by inhibiting Akt and downregulating matrix metalloproteinase-9 [198].…”

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confidence: 99%

Untitled

2015

Planta Med

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Introduction !Prostate cancer (PCa) is one of the most common malignancies in men and a leading cause of death worldwide for men. Taking into consideration that chemotherapy has severe side effects and usually a poor outcome, there is an intensive need for the development of safer and more effective agents. Since plants have been used by traditional medicine for the treatment of various diseases, in the last decades, many natural products have been isolated from plants and tested for their tumor selectivity and cytotoxic efficacy. Several of these naturally occurring compounds have been found to inhibit PCa growth and metastasis and are thus a promising approach for the treatment of this malignancy. Laboratory studies in different in vitro and in vivo systems have shown that these natural products modulate cellular processes, exhibit chemopreventive and/or chemotherapeutic effects, and induce apoptosis and autophagy. Accordingly, the antiproliferative and autophagic effects of nontoxic dietary agents could be of additional significance for the prevention, control, and management of PCa, specifically for the advanced and androgen-independent stage of the malignancy [1][2][3]. As there is increasing data on how natural compounds interfere with diverse molecular pathways in cancer cells, this review discusses the mechanism of action of bioactive natural products in the field of PCa and emphasizes the implicated molecular pathways of apoptosis and autophagy as important processes that control cellular homeostasis and that have been highlighted as promising targets for novel cancer therapies.Apigenin ! Apigenin (4′,5,7-trihydroxyflavone) is a flavone found in plants of the Asteraceae family, such as Anthemis sp., and many fruits and vegetables [4]. Apigenin has been tested in various types of cancer cell lines (breast, colon, liver, lung) showing promising results [5]. In prostate cancer in particular, apigenin administered in various concentrations (1-20 μΜ) for 24, 48, and 72 h not only causes G1 cell cycle arrest both in androgen-dependent (LNCaP) and -independent (DU145 and PC-3) PC cell lines through the decreased expression of cyclins D1, D2, and E, but also induces apoptosis through a shift in the Bax/Bcl-2 ratio [6,7]. Further studies in PC-3 cells have also demonstrated that apigenin (5-40 μΜ), delivered for 24 h, suppresses cell proliferation and induces apoptosis by inhibiting IGF-IGF-IR signaling and inactivating the PI3k/Akt pathway [8]. Apigenin Abstract ! Prostate cancer is one of the leading causes of death worldwide for men. There is increasing evidence that diet and lifestyle play a crucial role in prostate cancer biology and tumorigenesis. Due to the fact that conventional chemotherapy is not adequately effective against prostate cancer and has severe side effects, numerous in vitro studies have been conducted in order to identify the potent cytotoxic or chemopreventive activity of naturally occurring compounds and their respective molecular mechanisms of action. In this context, many natural compo...

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Isolation of oleanolic acid and ursolic acid from Thymus vulgaris, L.

Cited by 17 publications

References 8 publications

Micropropagation of Thyme (Thymus vulgaris L.)

Micropropagation of Thyme (Thymus vulgaris L.)

A Large Scale Safety Study to Investigate the Inclusion of Phytogenic Compounds in Broiler Chicken Feed

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