Isolation of Novel Adenovirus from Fruit Bat (<i>Pteropus dasymallus yayeyamae</i>)

Maeda, Ken; Hondo, Eiichi; Terakawa, Jumpei; Kiso, Yasuo; Nakaichi, Numekazu; Endoh, Daiji; Sakai, Kouji; Morikawa, Shigeru; Mizutani, Tetsuya

doi:10.3201/eid1402.070932

Cited by 77 publications

(67 citation statements)

References 5 publications

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“…The authors described an AdV almost identical to BtAdV-1 (AB303301) (with a single silent mutation on the short pol fragment), which was detected in the closely related species (Ryukyu flying fox, Pteropus dasymallus yayeyamae, Maeda et al, 2008). Based on our phylogeny inference, another AdV sequence derived from the Indian flying fox is most closely related (with two silent mutations) to the sea lion AdV sequence (GU979536) released most recently (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…In addition to being recognised as carriers of the pathogenic agents of several fearsome diseases such as rabies, SARS, influenza as well as Nipah, Hendra and Ebola viruses, bats may harbour a large variety of less dangerous viruses (Baker and Murcia, 2014;Kohl and Kurth, 2014;Reuter et al, 2014). The first bat AdV isolate was obtained from a Ryukyu flying fox (Pteropus dasymallus yayeyamae) in Japan during the establishment of bat cell cultures for the isolation of other viruses present in bats (Maeda et al, 2008).…”

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confidence: 99%

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Random sampling of the Central European bat fauna reveals the existence of numerous hitherto unknown adenoviruses

Vidovszky

Kohl

Boldogh

et al. 2015

Acta Veterinaria Hungarica

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From over 1250 extant species of the order Chiroptera, 25 and 28 are known to occur in Germany and Hungary, respectively. Close to 350 samples originating from 28 bat species (17 from Germany, 27 from Hungary) were screened for the presence of adenoviruses (AdVs) using a nested PCR that targets the DNA polymerase gene of AdVs. An additional PCR was designed and applied to amplify a fragment from the gene encoding the IVa2 protein of mastadenoviruses. All German samples originated from organs of bats found moribund or dead. The Hungarian samples were excrements collected from colonies of known bat species, throat or rectal swab samples, taken from live individuals that had been captured for faunistic surveys and migration studies, as well as internal organs of dead specimens. Overall, 51 samples (14.73%) were found positive. We detected 28 seemingly novel and six previously described bat AdVs by sequencing the PCR products. The positivity rate was the highest among the guano samples of bat colonies. In phylogeny reconstructions, the AdVs detected in bats clustered roughly, but not perfectly, according to the hosts' families (Vespertilionidae, Rhinolophidae, Hipposideridae, Phyllostomidae and Pteropodidae). In a few cases, identical sequences were derived from animals of closely related species. On the other hand, some bat species proved to harbour more than one type of AdV. The high prevalence of infection and the large number of chiropteran species worldwide make us hypothesise that hundreds of different yet unknown AdV types might circulate in bats.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Random sampling of the Central European bat fauna reveals the existence of numerous hitherto unknown adenoviruses

Vidovszky

Kohl

Boldogh

et al. 2015

Acta Veterinaria Hungarica

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“…Given that over 1000 bat species are known worldwide (Simmons, 2005), the prevalence and number of bat AdV types need to be further investigated. For example, only five successful adenoviral isolations from bats have been reported, including bat AdV-1 FBV1 from Pteropus dasymallus yayeyamae (Maeda et al, 2008), bat AdV-2 PPV1 from Pipistrellus pipistrellus (Sonntag et al, 2009), bat AdV-3 TJM from Myotis ricketti (Li et al, 2010), bat AdV-4 from Rousettus leschenaulti (Raut et al, 2012) and the putative bat AdV-5 from Eidolon helvum . Full-length genomic sequences are currently only available for the TJM and PPV1 strains (Kohl et al, 2012;Li et al, 2010), which were used to establish the species Bat mastadenovirus A and B, respectively.…”

Section: Introductionmentioning

confidence: 99%

Novel bat adenoviruses with an extremely large E3 gene

Teng

Yang

et al. 2016

Journal of General Virology

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“…The first bat AdV was isolated from a fruit bat in the suborder Megachiroptera (12). In 2008, we isolated the first AdV (bat adenovirus 2 Pipistrellus pipistrellus virus 1 [BtAdV-2 PPV1]) from a microchiropteran bat in Germany (13).…”

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Genome Analysis of Bat Adenovirus 2: Indications of Interspecies Transmission

Kohl

Vidovszky

Mühldorfer

et al. 2012

J Virol

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The genome of bat adenovirus 2 was sequenced and analyzed. It is similar in size (31,616 bp) to the genomes of bat adenovirus 3 and canine adenoviruses 1 and 2. These four viruses are monophyletic and share an identical genome organization, with one E3 gene and four E4 genes unique to this group among the mastadenoviruses. These findings suggest that canine adenoviruses may have originated by interspecies transfer of a vespertilionid bat adenovirus.

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Isolation of Novel Adenovirus from Fruit Bat (Pteropus dasymallus yayeyamae)

Abstract: Isolation of Novel Adenovirus from Fruit Bat

Cited by 77 publications

References 5 publications

Random sampling of the Central European bat fauna reveals the existence of numerous hitherto unknown adenoviruses

Random sampling of the Central European bat fauna reveals the existence of numerous hitherto unknown adenoviruses

Novel bat adenoviruses with an extremely large E3 gene

Genome Analysis of Bat Adenovirus 2: Indications of Interspecies Transmission

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