Isolation of new steroids of Kala Dhaman grass (Cenchrus setigerus) and evaluation of their bioactivity

Singariya, Premlata; Kumar, Pramod; Mourya, Krishan Kumar

doi:10.1590/s1516-89132014000100010

Cited by 6 publications

(4 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This grass is gaining attention in various field of research as it is more competitive in high temperature, solar radiation and low moisture. It is most suitable and highly nutritive grass for environmental conditions of desert 7 .…”

Section: Introductionmentioning

confidence: 99%

Screening and Evaluation of Bioactive Components of Cenchrus Ciliaris L. By Gc-MS Analysis

Arora¹,

Kumar²,

Meena³

2017

Int. Res. J. Pharm.

View full text Add to dashboard Cite

Plants are rich source of secondary metabolites with interesting biological activities. Cenchrus ciliaris L. is an important forage plant belonging to grass family (Poaceae). The objective of the present investigation was to characterize possible bioactive phytochemical constituents from the whole plant of C. ciliaris L. using methanol by gas chromatography-mass spectrometry (GC-MS) analysis. The shade-dried plant powder was extracted with methanol using Soxhlet extractor and crude extract was subjected to GC-MS. The phytochemical constituents were investigated using Perkin-Elmer gas chromatography-mass spectrometry, while the mass spectra of the compounds found in the extract was matched with the National Institute of Standards and Technology (NIST) and Willey 8 library. Maximum % area is found for Stigmasta -5, 22-Dien-3-ol, is present in maximum amount (12.68%) with RT = 36.461 min. in the methanolic root extract. 6,6-Dideutero-nonen-1-ol-3, is present in maximum amount (31.92 %) with RT=12.088 min. in the methanolic stem extract and Pentadecanoic acid is present in maximum amount (20.04%) with RT= 16.328 min. in the leaf extract of Cenchrus ciliaris L. Green plants synthesize and preserve a variety of biochemical compounds, these products include flavonoids, phenols, saponins, terpenes, steroids and glycosides. C4 plants, specifically in warm conditions may show more potentialities to defend themselves. These compounds are commercially important and are used by pharmaceutical industries as well as the traditional practitioners for making herbal/synthetic drug formulations.

show abstract

Section: Introductionmentioning

confidence: 99%

Screening and Evaluation of Bioactive Components of Cenchrus Ciliaris L. By Gc-MS Analysis

Arora¹,

Kumar²,

Meena³

2017

Int. Res. J. Pharm.

View full text Add to dashboard Cite

show abstract

“…The existence of steroid compounds has previously been documented in different parts of Censchrus spp. (Singariya et al, 2012(Singariya et al, , 2014. Therefore, the presence of different bioactive steroid compounds could be speculated in C. pennnisetiformis as well that probably confer resistance against F. oxysporum.…”

Section: Resultsmentioning

confidence: 99%

FUNGICIDAL POTENTIAL OF ALLELOPATHIC WEED Cenchrus pennisetiformis ON GROWTH OF Fusarium oxysporum f. sp. lycopersici UNDER CHROMIUM STRESS

et al. 2016

View full text Add to dashboard Cite

The present study was conducted to assess antifungal potential of the allelopathic grass Cenchrus pennisetiformis Hochst. & Steud. against the fungal plant pathogen Fusarium oxysporum f. sp. lycopersici (cause of tomato wilt disease) under chromium stress. Laboratory experiments were performed in 10 mL volume glass test tubes each containing 1.0 mL of malt extract broth with seven concentrations (0, 50, 100, 150, 200, 250, 300 and 350 ppm) of each of Cr(III) and Cr(VI), and two concentrations (5% and 6%) of methanolic leaf, stem or root extract of C. pennisetiformis. A metal + weed extract amended medium was inoculated with the pathogen and incubated for 7 days at 25 C. Different concentrations of Cr(III) and Cr(VI) proved equally inhibitory resulting in 10-84% and 18-89% reduction in fungal biomass, respectively. Methanolic leaf, stem and root extracts of the weed reduced fungal biomass by 12-25%, 14-23% and 46-50%, respectively, over negative control. In combined application of methanolic extracts of different parts of C. pennisetiformis and metal solutions, root extract in combination with either Cr(III) or Cr(VI) showed the highest inhibitory potential against the fungus followed by leaf and stem extracts. In combination with methanolic root, leaf and stem extracts, different concentrations of Cr(III) and Cr(VI) significantly reduced fungal biomass by 54-99%, 14-99% and 9-95%, respectively, over negative control. Such studies have not been carried out previously. Results of the present investigation suggest that F. oxysporum oxysporum f. sp. lycopersici, the cause of Fusarium wilt disease in tomato, can be managed by application of extracts (or alternatively biomass) of C. pennisetiformis in chromium contaminated soils.

show abstract

“…Other authors, including Haider et al [ 35 ] and Jasso de Rodríguez et al [ 36 ], isolated this compound in other plant species, Adiantum capillus -Veneris and Psacalium paucicapitatum , respectively. This compound (Ethyl iso-allocholate) of steroidal nature has been reported as a potential therapeutic agent, as it has diuretic, anti-inflammatory, anticancer and antimicrobial activities [ 35 , 36 , 37 ]. Chokki et al [ 6 ] also reported that the antimicrobial activity observed with these plants would be attributed to their chemical composition.…”

Section: Discussionmentioning

confidence: 99%

Ethnopharmacological Value and Biological Activities via Antioxidant and Anti-Protein Denaturation Activity of Morinda lucida Benth and Momordica charantia L. Leaves Extracts from Benin

Dah-Nouvlessounon

Chokki

Noumavo

et al. 2023

Plants

View full text Add to dashboard Cite

Momordica charantia Linn. (Cucurbitaceae), the wild variety of bitter melon, and Morinda lucida Benth (Rubiaceae) were commonly used as a popular folk medicine in Benin. This study aimed to appreciate the ethnopharmacological knowledge and evaluate the antioxidant and anti-inflammatory effects of M. charantia and M. lucida leaves extracts. Semi-structured surveys supported by individual interviews were conducted with herbalists and traditional healers in southern Benin. The antioxidant activities were evaluated by a micro-dilution technique using ABTS and FRAP methods. These activities were supported by cyclic voltammetry analysis. The anti-inflammatory activity was evaluated by the albumin denaturation method. The volatile compounds were analysed by GC-MS analysis. All the respondents involved in this study have good knowledge of the two plants. We identify 21 diseases grouped into five categories of condition. The two plants’ extracts possess variable antioxidant capacity. Indeed, all the active extracts of M. charantia presented an IC50 < 0.078 mg/mL, while the extracts of M. lucida had an IC50 up to 0.21 ± 0.02 mg/mL. For anti-inflammatory activity, a dose-response activity (p < 0.001) was observed in the protein denaturation inhibition rate of the extracts. It should be noted that the highest inhibition rate (98.34 ± 0.12) of the albumin denaturation was observed with M. lucida dichloromethane extract. A total of 59 volatile compounds were identified by GC-MS analysis in the extracts of the two plants. The M. charantia ethyl acetate extract shows the presence of 30 different compounds with a relative abundance of 98.83%, while that of M. lucida shows 24 compounds with a relative abundance of 98.30%. These plants are potential candidates to discover new compounds with therapeutic properties that could be used to solve public health problems.

show abstract

Isolation of new steroids of Kala Dhaman grass (Cenchrus setigerus) and evaluation of their bioactivity

Abstract: The present study was carried out to determine the possible bioactive components (steroids) -stigmasta-4,22-dien-3-one(4.93%), δ4-sitosterol-3-one (stigmast-4-en-3-one)

Cited by 6 publications

References 10 publications

Screening and Evaluation of Bioactive Components of Cenchrus Ciliaris L. By Gc-MS Analysis

Screening and Evaluation of Bioactive Components of Cenchrus Ciliaris L. By Gc-MS Analysis

FUNGICIDAL POTENTIAL OF ALLELOPATHIC WEED Cenchrus pennisetiformis ON GROWTH OF Fusarium oxysporum f. sp. lycopersici UNDER CHROMIUM STRESS

Ethnopharmacological Value and Biological Activities via Antioxidant and Anti-Protein Denaturation Activity of Morinda lucida Benth and Momordica charantia L. Leaves Extracts from Benin

Contact Info

Product

Resources

About