Isolation of Neisseria meningitidis from the urethra, cervix, and anal canal: further observations.

Givan, Kathleen F.; Thomas, Brunner; Johnston, Alisha

doi:10.1136/sti.53.2.109

Cited by 38 publications

(15 citation statements)

References 12 publications

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“…As the rectum and urethra are physiologically distinct from the nasopharynx, factors such as the polysaccharide capsule, a wellknown meningococcal virulence determinant, may be important for colonisation and persistence (table 1), consistent with the prevalence of encapsulated strains identified here and previously. [28][29][30] The expansion of meningococci into this environment may result in adaptation leading to the emergence of strains that are able to persist by novel means of colonisation and transmission. An example is the gene aniA encoding nitrite reductase and essential for the growth of gonococci under oxygen-limiting conditions.…”

Section: Discussionmentioning

confidence: 99%

Genomic analysis of urogenital and rectalNeisseria meningitidisisolates reveals encapsulated hyperinvasive meningococci and coincident multidrug-resistant gonococci

et al. 2017

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ObjectiveInvasive meningococcal disease (IMD) outbreaks in men who have sex with men (MSM) have been associated with meningococcal colonisation of the urethra and rectum, but little is known about this colonisation or co-colonisation with the closely related gonococcus. Whole genome sequencing (WGS) was employed to explore these phenomena.MethodsMeningococci isolated from the urogenital tract and rectum (n=23) and coincident gonococci (n=14) were analysed by WGS along with contemporary meningococci from IMD (n=11). All isolates were obtained from hospital admissions in Brighton, UK, 2011–2013. Assembled WGS were deposited in the PubMLST/neisseria database (http://pubmlst.org/neisseria) and compared at genomic loci common to gonococci or meningococci.ResultsAs expected, most meningococci from IMD were encapsulated and belonged to hyperinvasive lineages. So too were meningococci found in the urogenital tract and rectum, contrasting to those asymptomatically carried in the nasopharynx where such meningococci are rare. Five hyperinvasive meningococcal lineages and four distinct gonococcal genotypes were recovered, including multiresistant ST-1901 (NG MAST-1407) gonococci.ConclusionsThese data were consistent with a predisposition for potentially virulent encapsulated hyperinvasive meningococci to colonise the urethra and rectum, which suggests their involvement in MSM IMD outbreaks. The coincidence of multiresistant gonococci raises wider public health concerns.

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Section: Discussionmentioning

confidence: 99%

Genomic analysis of urogenital and rectalNeisseria meningitidisisolates reveals encapsulated hyperinvasive meningococci and coincident multidrug-resistant gonococci

et al. 2017

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“…Meningococci of clinical importance have been isolated from genitourinary sites (8,11). Furthermore, the occurrence of double infections with N. meningitidis and N. gonorrhoeae (8) increase the possibility that beta-lactamase-producing N. gonorrhoeae isolates may transfer their plasmids to the meningococcus.…”

Section: Methodsmentioning

confidence: 99%

Conjugal Transfer of Beta‐Lactamase‐Producing Plasmids of Neisseria gonorrhoeae to Neisseria meningitidis

Ikeda

Tsuji

Kaneko

et al. 1986

Microbiology and Immunology

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Twenty clinical isolates of beta-lactamase-producing Neisseria gonorrhoeae from Japanese sources were studied to define their ability to serve as donors for their plasmids in conjugation with Neisseria meningitidis. These twenty strains of N. gonorrhoeae harbored the 4.5-megadalton (Mdal) beta-lactamase-producing plasmids and the 24.5-Mdal conjugative plasmids. We found that only three of twenty N. gonorrhoeae strains showed a detectable conjugation frequency ( >10-5) with N. meningitidis as the recipient although all strains were capable of mobilizing beta-lactamase-producing plasmids to N. gonorrhoeae and to Escherichia coli. The 4.5-Mdal beta-lactamase-producing plasmid was maintained in N. meningitidis, but the large 24.5-Mdal conjugative plasmid has not been found in N. meningitidis transconjugants.

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“…Meningococci have been isolated from the genitourinary tract of patients both with [72][73][74][75][76][77][78][79][80][81] and without 76 78 79 82 symptoms. Urethritis due to meningococci was first reported in 1942, 72 and several case reports suggest that it may be associated with oro-genital contact.…”

Section: Neisseria Meningitidismentioning

confidence: 99%

Oral sex and transmission of non-viral STIs

Edwards

Carne

1998

Sexually Transmitted Infections

165

116

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Objectives:To review the literature on the role of oral sex in the transmission of non-viral sexually transmitted infections (STIs). Method: A Medline search was performed using the keywords oro-genital sex, and those specific to each infection. Further references were then taken from each article read. Conclusions: Oral sex is a common sexual practice between both heterosexual and homosexual couples. Oro-genital sex is implicated as a route of transmission for gonorrhoea, syphilis, Chlamydia trachomatis, chancroid, and Neisseria meningitidis. Other respiratory organisms such as streptococci, Haemophilus influenzae, and Mycoplasma pneumoniae could also be transmitted by this route. Fellatio confers risk for acquisition of infection by the oral partner. Cunnilingus appears to predispose to recurrent vaginal candidiasis although the mechanism for this is unclear, while a link between oro-genital sex and bacterial vaginosis is currently being studied. Oro-anal sex is implicated in the transmission of various enteric infections. In view of the increased practice of oral sex this has become a more important potential route of transmission for oral, respiratory, and genital pathogens. (Sex Transm Inf 1998;74:95-100)

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Isolation of Neisseria meningitidis from the urethra, cervix, and anal canal: further observations.

Cited by 38 publications

References 12 publications

Genomic analysis of urogenital and rectalNeisseria meningitidisisolates reveals encapsulated hyperinvasive meningococci and coincident multidrug-resistant gonococci

Genomic analysis of urogenital and rectalNeisseria meningitidisisolates reveals encapsulated hyperinvasive meningococci and coincident multidrug-resistant gonococci

Conjugal Transfer of Beta‐Lactamase‐Producing Plasmids of Neisseria gonorrhoeae to Neisseria meningitidis

Oral sex and transmission of non-viral STIs

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