Isolation of Myosin Light Chain Kinase Inhibitors from Microorganisms: Dehydroaltenusin, Altenusin, Atrovenetinone, and Cyclooctasulfur

Nakanishi, Satoshi; Toki, Shinichiro; Saitoh, Yutaka; Tsukuda, Eiji; Kawahara, Kiyotaka; Ando, Katsuhiko; Matsuda, Yuzuru

doi:10.1271/bbb.59.1333

Cited by 49 publications

(56 citation statements)

References 2 publications

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“…The purified compound was implicated as 1 by comparison of the NMR data in CDCl 3 with the reported data by Nakanishi et al [13]. Atrovenetinone (2) is easily converted into an acetal in alcohol (Fig.…”

mentioning

confidence: 88%

“…The active compound was identified as a phenalenone compound, atrovenetinone methyl acetal (1, Fig. 1) [13]. This paper presents integrase-inhibiting and anti-HIV activities of 1 and other natural phenalenones.…”

mentioning

confidence: 94%

“…Atrovenetinone (2) is easily converted into an acetal in alcohol (Fig. 2) [14], and the acetal is a mixture of diastereomers [13]. So, the NMR spectra of 1 are complicated.…”

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confidence: 99%

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Fungal Phenalenones Inhibit HIV-1 Integrase

et al. 2005

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confidence: 88%

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confidence: 94%

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Fungal Phenalenones Inhibit HIV-1 Integrase

et al. 2005

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“…Dehydroaltenusin (17) from Penicillium verruculosum IAM-13756 inhibited the calmodulindependent activity of myosin light chain kinase (MLCK) with IC 50 value of 0.69 μM [46].…”

Section: Other Bioactivitiesmentioning

confidence: 99%

Natural Dibenzo-α-Pyrones and Their Bioactivities

Mao

Sun

et al. 2014

Molecules

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Natural dibenzo-α-pyrones are an important group of metabolites derived from fungi, mycobionts, plants and animal feces. They exhibit a variety of biological activities such as toxicity on human and animals, phytotoxicity as well as cytotoxic, antioxidant, antiallergic, antimicrobial, antinematodal, and acetylcholinesterase inhibitory properties. Dibenzo-α-pyrones are biosynthesized via the polyketide pathway in microorganisms or metabolized from plant-derived ellagitannins and ellagic acid by intestinal bacteria. At least 53 dibenzo-α-pyrones have been reported in the past few decades. This mini-review aims to briefly summarize the occurrence, biosynthesis, biotransformation, as well as their biological activities and functions. Some considerations related to synthesis, production and applications of dibenzo-α-pyrones are also discussed.

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“…(8), and elemental sulfur is known as a metabolite of Streptomyces sp. (2,6). Antibiotic activity of elemental sulfur toward some bacteria has also been known to occur (5).…”

Section: Discussionmentioning

confidence: 99%