Isolation of MRSA, ESBL and AmpC – β -lactamases from Neonatal Sepsis at a Tertiary Care Hospital

Abstract

Background and Objectives: The emergence of methicillin resistant Staphylococcus aureus (MRSA) and extended spectrum β-lactamases (ESBLs) in neonatal intensive care unit patients is increasing.

Clinical and bacteriological study of neonatal septicaemia in a tertiary care hospital

“…2 In present study, the most frequently isolated organism was Klebsiella pneumoniae 54 (26.34%) followed by S. aureus 36 (17.56%). Our findings were similar to Muley VA et al 18 K. pneumoniae was reported as a predominant pathogen in NNPD Report 2002-2003 and also by Sharma CM et al, Iregbu et al, Chelliah A et al and Tankhiwale SS et al 3,11,[27][28][29] K.pneumoniae and S. aureus can survive in the environment for a relatively long time and fairly widely distributed in the hospital environment and therefore have the potential for being transmitted from the environment to the patients through practices that breach infection control measures.…”

“…Our result matches with Chelliah A et al 11 who reported E. coli in 7.2% and P. aeruginosa in 10% of the cases respectively.…”

“…There is wide variation in the culture positivity worldwide ranging from 5% to 60.4%. 10,11 These variations may be due to differences in predisposing factors and infection control practices in the different centres. Our findings were similar to the prevalence rate of 37.69% and 32% reported by Sharma CM et al and Gandhi S et al respectively from India.…”

“…2 Our findings were comparable with Jyothi P et al, Chiliah A et al and Sharma CM et al who reported CONS in 27.5%, 10.9% and 4.38% cases respectively. 14,11,29 The bacteriological profile differs in EONS and LONS and it also differs in developing and developed countries. In developed countries, gram-positive organism is predominant in both EONS and LONS whereas in developing countries gram negative organism is predominant in both EONS and LONS.…”

Microbiological Profile of Neonatal Septicemia in a Rural Teaching Hospital of North India

“…In present study, 7(58%) were MRSA which were more than MSSA similar to Chelliah. A et al (18) (MRSA 56%) in contrast Kaistha.N et al (19) (11.11%).The higher rate of MRSA could, to a great extent be attributed to the fact that these organisms are now both hospital acquired and community flora. In present study all MRSA were 100% sensitive to Vancomycin.…”