Isolation of Morganella Morganii and Providencia Species from Clinical Samples in a Tertiary Care Hospital in North India

Abstract

Introduction: The members of the tribe Proteeae, Morganella and Providencia are being increasingly recognized as important pathogens. The spectrum of disease caused by them is wide and in reported cases the mortality is high. Previously both these pathogens were considered to be rare pathogens as the potential to cause nosocomial transmission and infection was not much studied. But their phenomenal evolution and increase in multidrug-resistance (MDR) strains of these pathogens are posing a major threat toward public health throughout the world. Material and Methods: This present study was carried out from July 2018 to December 2018 on all the pus and body fluid samples that were received in Department of Microbiology. Samples were processed as per standard Microbiological guidelines and alsowere analyzed for their antimicrobial susceptibility profile as per Clinical Laboratory Standards Institute. Results: Out of 8425 samples received, 2140 were culture positive, amongst which 19 samples (0.89%) were positive for Providencia species (9) and Morganella morganii(10). The male : female ratio of these 19 patients was 2.8 : 1 and maximum patients (13) belonged to 20-60 years.As far as risk factors are concerned, maximum patients were diabetics (7) followed by abnormal liver function tests(6),concomitant UTI (6), history ofinvasive procedure (5), prior exposure to antibiotics (5) and urinary catheterization (4). About 6 were polymicrobial infections.Antibiotic susceptibility patterns revealed that Providencia strains were sensitive to ampicillin- sulbactum (77.7%) and amikacin (77.7%) while all Morganella strains were 100% sensitive to tobramycin and piperacillin tazobactam. Conclusion: This study heralds in a need for more research in this area as infections caused by these two pathogens are on the rise.Moreover,resistance to antimicrobials is also an increasingly common problem thus delaying the treatment and prognosis of disease.

Multidrug Resistant Bacterial Profile and Patterns for Pus Isolates and Recurrent Wound Infections in Nongovernmental Hospitals of Jordan

“…Acintobactoer spp is presented strongly in the results as a causative agents pus-causing microbes which is formed approximate 3.1% of pus's infections in Jordan, 2% for MDR strains and 1% for non MDR species, the risk in Acintobactoer spp infections in its membership among ESKAPE group (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter cloacae) and the resistancey and spreading within healthcare centers [13,14]. E. coli caused approximate 1/5 over all of the pus's infections by percentage of 21.4%,this showed that the most pus-causing infections caused by E. coli non extended spectrum βlactamase (ESβL), but the percentage of the Nonhemolytic streptococci bacteria was relatively high by percentage of 9.2%, and Streptococcus agalactiae ( group B) formed 4.1%.…”

“…The multidrug resistant (MDR) and pan drugresistant (PD) gram-negative bacteria, is less prevalent than MRSA. Recently, the MDR and extensively drug resistant (XDR) strains of Mycobacterium tuberculosis were starting to make an actual threat in the developing world [9,11,[12][13][14][15][16][17].…”

Characterization of Opportunistic Pathogenic Multi-Drug Resistant Bacteria Isolated from Marine Coastal Water in Jazan, Saudi Arabia

“…In fact, Providencia spp. has been reported as a normal flora of the human intestinal tract and are the most common causes of infections in hospitalized patients [26,27]. However, some Providencia species were isolated from wastewater and contaminated soil [28,29].…”