Isolation of metal-binding fractions from tobacco smoke condensate

Finelli, Vincent N.; Menden, E.; Petering, Harold G.

doi:10.1021/es60067a012

Cited by 8 publications

(1 citation statement)

References 10 publications

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“…About 70% of the cadmium in a cigarette is estimated to pass into the smoke (Nandi et al, 1969). The total smoke condensate from nonfilter research cigarettes has been shown to have a cadmium-binding capacity of 8.3 jumol per cigarette (Finelli et al, 1972). The percentage of nickel we found in the particulate phase appeared to be unrelated to the concentration of the element in the tobacco.…”

Section: Resultsmentioning

confidence: 69%

Cadmium and nickel in smoke of cigarettes prepared from tobacco cultured on municipal sludge‐amended soil

Gutenmann

Bache

Lisk

et al. 1982

Journal of Toxicology and Environmental Health

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Cigarettes prepared from tobacco grown on municipal sludge-amended soil were smoked, and the mainstream particulates and gaseous fractions were analyzed for total cadmium and nickel content. Sludge-grown and control (soil-grown) tobaccos contained, respectively, 67.4 and 3.18 ppm of cadmium and 19.4 and 1.29 ppm of nickel. The quantities of cadmium (microgram per cigarette) found in the mainstream particulate and gaseous fractions were, respectively, 6.67 and 0.04 for the sludge-grown and 0.21 and 0.03 for the control treatments. The quantities of nickel (microgram per cigarette) found in the mainstream particulates and gaseous fractions were, respectively, 0.11 and 0.07 for the sludge-grown and 0.01 and 0.01 for the control treatments. The potential public health implications of these results and modifying factors are discussed.

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Section: Resultsmentioning

confidence: 69%

Cadmium and nickel in smoke of cigarettes prepared from tobacco cultured on municipal sludge‐amended soil

Gutenmann

Bache

Lisk

et al. 1982

Journal of Toxicology and Environmental Health

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Cadmium accumulation in the lung, liver and kidney of mice and rats chronically exposed to cigarette smoke

Gairola

Wagner

1991

J of Applied Toxicology

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Cigarette smoking constitutes a major source of cadmium exposure via inhalation in man. To determine how smoke exposure affects the organ distribution and accumulation of cadmium, male C57B1 mice and Sprague-Dawley rats were exposed daily for 52-60 consecutive weeks to mainstream smoke from the University of Kentucky reference cigarettes (2R1) in a nose-only exposure system. Exposed mice and rats averaged blood carboxyhemoglobin values of 17.7 and 7.2%, and a daily total particulate matter (TPM) dose of 7.2 and 3.2 mg kg-1 body wt. per exposure, respectively. These results suggested effective inhalation of smoke by the animals. The tissues were acid digested and analyzed for cadmium by atomic absorption spectrometry. Cadmium levels 5-6- and 2-3-fold greater than control levels were detected in the lungs and kidneys, respectively, of exposed animals of both species. In contrast, the liver did not show increased cadmium levels in exposed mice or rats. The data suggest that low-dose chronic inhalation exposure to cigarette smoke leads to highest cadmium accumulation in the lung, followed by the kidney, with minimal effects on cadmium levels in the liver.

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Tobacco-borne siderophoric activity

Qian

Eaton

1989

Archives of Biochemistry and Biophysics

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Isolation of metal-binding fractions from tobacco smoke condensate

Cited by 8 publications

References 10 publications

Cadmium and nickel in smoke of cigarettes prepared from tobacco cultured on municipal sludge‐amended soil

Cadmium and nickel in smoke of cigarettes prepared from tobacco cultured on municipal sludge‐amended soil

Cadmium accumulation in the lung, liver and kidney of mice and rats chronically exposed to cigarette smoke

Tobacco-borne siderophoric activity

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