ISOLATION OF MELATONIN, THE PINEAL GLAND FACTOR THAT LIGHTENS MELANOCYTES<sup>1</sup>

Lerner, Aaron B.; Case, James D.; Takahashi, Y; Lee, Teh H.; Mori, Wataru

doi:10.1021/ja01543a060

Cited by 1,576 publications

(732 citation statements)

References 4 publications

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“…The first evidence that exogenous melatonin affects wakefulness was provided by the work of Aaron Lerner, who discovered melatonin in 1958 (Lerner et al, 1958). When he started to treat patients suffering from vitiligo, a human pigmentation disease, he noted that many of his patients became sleepy and fell asleep.…”

Section: B Effects Of Exogenous Melatonin On Human Sleep and Wakefulmentioning

confidence: 99%

What Keeps Us Awake?—the Role of Clocks and Hourglasses, Light, and Melatonin

Cajochen

Chellappa

Schmidt

2010

International Review of Neurobiology

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Section: B Effects Of Exogenous Melatonin On Human Sleep and Wakefulmentioning

confidence: 99%

What Keeps Us Awake?—the Role of Clocks and Hourglasses, Light, and Melatonin

Cajochen

Chellappa

Schmidt

2010

International Review of Neurobiology

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“…1) is an indolamine isolated for the first time by Aaron Lerner in the 1950s from the bovine pineal gland (Lerner et al 1958).…”

Section: Introductionmentioning

confidence: 99%

Interactions of melatonin with mammalian mitochondria. Reducer of energy capacity and amplifier of permeability transition

et al. 2011

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Melatonin, a metabolic product of the amino acid tryptophan, induces a dose-dependent energy drop correlated with a decrease in the oxidative phosphorylation process in isolated rat liver mitochondria. This effect involves a gradual decrease in the respiratory control index and significant alterations in the state 4/state 3 transition of membrane potential (DW). Melatonin, alone, does not affect the insulating properties of the inner membrane but, in the presence of supraphysiological Ca 2? , induces a DW drop and colloid-osmotic mitochondrial swelling. These events are sensitive to cyclosporin A and the inhibitors of Ca 2? transport, indicative of the induction or amplification of the mitochondrial permeability transition. This phenomenon is triggered by oxidative stress induced by melatonin and Ca 2? , with the generation of hydrogen peroxide and the consequent oxidation of sulfydryl groups, glutathione and pyridine nucleotides. In addition, melatonin, again in the presence of Ca 2? , can also induce substantial release of cytochrome C and AIF (apoptosis-inducing factor), thus revealing its potential as a pro-apoptotic agent.

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“…Melatonin acts as a hormone (1,2), receptor independent autocrine and paracrine antioxidant (3,4), direct radical scavenger (3,5), immunomodulator (6), antiaging factor (7,8) and anticarcinogen (9) depending on the concentrations (10). Increasing evidence in the field suggests that melatonin acts at many extrapineal sites such as the gastrointestinal tract (11,12), the blood cell system (13), the retina (14), the bone marrow (15,16) and the skin (17)(18)(19)(20)(21)(22).…”

Section: Introductionmentioning

confidence: 99%

Oncostatic effects of the indole melatonin and expression of its cytosolic and nuclear receptors in cultured human melanoma cell lines

Fischer

Żmijewski²,

Zbytek³

et al. 2006

Int J Oncol

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Abstract.Melatonin has been shown to have oncostatic effects on malignant melanoma in vitro and in vivo. We studied the growth suppressive effects of melatonin over a wide range of concentrations in four melanoma cell lines (SBCE2, WM-98, WM-164 and SKMEL-188) representative for different growth stages and phenotype. Melanoma cells were incubated with melatonin 10 -12 -10 -3 M, and proliferation and clonogenicity was assessed at 12 h and 14 days, respectively. We also determined the expression of cytosolic quinone oxidoreductases NQO1, NQO2 (known as MT3 receptor) and nuclear receptor ROR· by RT-PCR. Melatonin at pharmacological concentrations (10 -3 -10 -7 M) suppressed proliferation in all melanoma cell lines. In SKMEL-188 cells cultured in serum-free media, melatonin at low concentrations (10 -12 -10 -10 M) also slightly attenuated the proliferation. The effects of pharmacological doses of melatonin were confirmed in the clonogenic assay. Expression of NQO1 was detected in all cell lines, whereas NQO2 and nuclear receptor ROR· including its isoform ROR·4 were present only in SBCE2, WM-164 and WM-98. Thus, melatonin differentially suppressed proliferation in melanoma cell lines of different behaviour. The intensity of the oncostatic response to melatonin could be related to the cell-line specific pattern of melatonin cellular receptors and cytosolic binding protein expression.

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ISOLATION OF MELATONIN, THE PINEAL GLAND FACTOR THAT LIGHTENS MELANOCYTES¹

Cited by 1,576 publications

References 4 publications

What Keeps Us Awake?—the Role of Clocks and Hourglasses, Light, and Melatonin

What Keeps Us Awake?—the Role of Clocks and Hourglasses, Light, and Melatonin

Interactions of melatonin with mammalian mitochondria. Reducer of energy capacity and amplifier of permeability transition

Oncostatic effects of the indole melatonin and expression of its cytosolic and nuclear receptors in cultured human melanoma cell lines

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ISOLATION OF MELATONIN, THE PINEAL GLAND FACTOR THAT LIGHTENS MELANOCYTES1

Cited by 1,576 publications

References 4 publications

What Keeps Us Awake?—the Role of Clocks and Hourglasses, Light, and Melatonin

What Keeps Us Awake?—the Role of Clocks and Hourglasses, Light, and Melatonin

Interactions of melatonin with mammalian mitochondria. Reducer of energy capacity and amplifier of permeability transition

Oncostatic effects of the indole melatonin and expression of its cytosolic and nuclear receptors in cultured human melanoma cell lines

Contact Info

Product

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ISOLATION OF MELATONIN, THE PINEAL GLAND FACTOR THAT LIGHTENS MELANOCYTES¹