Isolation of linoleic acid as an estrogenic compound from the fruits of Vitex agnus-castus L. (chaste-berry)

Five New Diterpenoids, Viteagnusins A-E, from the Fruit of Vitex agnus-castus

“…[1][2][3][4][5][6][7][8][9] Further, linoleic acid isolated from this fruit was identified as an estrogenic compound. 10) In the course of our study on the constituents of Verbenaceae plants, [11][12][13][14] we have investigated the constituents of the fruit of V. agnus-castus. The present paper describes the isolation and structural elucidation of five new diterpenoids along with two known diterpenoids.…”

Three New Diterpenoids from the Fruit of Vitex agnus-castus

“…[1][2][3][4][5][6][7][8][9] Further, linoleic acid isolated from this fruit was identified as an estrogenic compound. 10) In a previous paper, 11) we reported the isolation and structural elucidation of seven diterpenoids from the hexane extract of V. agnuscastus. As part of an ongoing study of this plant, we presently describe the isolation and structural characterization of three new labdane-type diterpenoids along with seven known compounds including four labdane-type diterpenoids, one norlabadane-type diterpenoid, one aromadendrane-type sesquiterpenoid, and one flavonoid from the hexane extract.…”

Introduction to Traditional Herbal Medicines and their Study

“…Such results may disappoint researchers looking for new drug development, but they are very helpful to scientists who are dedicated to explaining the functions of herbs or willing to understand more about physiological functions of these common compounds in the human body. Examples include linolic acid, a cyclooxygenase (COX) inhibitor in Angelica pubescens 3 and an estrogenic agonist in Vitex agnus -castus L. (chaste berry), 4 and N ω -methylserotonin, a serotonin agonist in black cohosh. 5…”