Isolation of Legionella pneumophila from blood culture.

Macrae, A.D.; Greaves, P W; Platts, P

doi:10.1136/bmj.2.6199.1189-a

Cited by 22 publications

(10 citation statements)

References 4 publications

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“…pneumophila was actually very few [30][31][32], this case suggests that blood culture is worth trying when UAT results are negative and sputum is not discharged when LD is suspected.…”

Section: Discussionmentioning

confidence: 99%

Detection of Legionella pneumophila serogroup 1 in blood cultures from a patient treated with tumor necrosis factor-alpha inhibitor

Kaku

Yanagihara

Morinaga

et al. 2013

Journal of Infection and Chemotherapy

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A 65-year-old man was admitted to our hospital with a fever of 39.3°C, cough, sputum and pharyngeal discomfort that had persisted for three days. Rheumatoid arthritis had been treated with methotrexate and adalimumab for two years and pancreatic metastasis of gastric cancer had been treated with S-1 (tegafur, gimeracil, and oteracil potassium) for two months. Regardless of the underlying pathologies, his general condition was good and he had worked as an electrician until two days before admission. However, his appetite had suddenly decreased from the day before admission, and high fever and hypoxia were also evident upon admission. A chest X-ray and computed tomography scan revealed left pleural effusion and consolidation in both lungs. The pneumonia severity index score was 165 and risk class was V. Accordingly, we started to treat the pneumonia with a combination of levofloxacin and meropenem. Thereafter, we received positive urinary antigen test (UAT) findings for Legionella pneumophila. Despite the application of appropriate antibiotics, vasopressors and oxygenation, the hypotension and hypoxia progressed and the patient died eight hours after admission. Even after his death, blood cultures had been continued to consider the possibility of bacterial co-infection. Although no bacteria were detected from blood cultures, Gimenez staining 3 revealed pink bacteria in blood culture fluids. Subsequent blood fluid culture in selective medium revealed L. pneumophila serogroup 1.

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“…pneumophila was actually very few [30][31][32], this case suggests that blood culture is worth trying when UAT results are negative and sputum is not discharged when LD is suspected.…”

Section: Discussionmentioning

confidence: 99%

Detection of Legionella pneumophila serogroup 1 in blood cultures from a patient treated with tumor necrosis factor-alpha inhibitor

Kaku

Yanagihara

Morinaga

et al. 2013

Journal of Infection and Chemotherapy

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“…There have not been many documented cases of Legionella bacteremia. Single isolations have been reported by using biphasic blood culture media and supplemented proteose peptone broth (45,101,105,106). The BACTEC 460 instrument recovered isolates variably: in one study, aerobic 6B bottles were positive by growth index and subculture whereas the anaerobic 7D bottles were negative (32); in another study, the 7D bottles were positive by blind subculture whereas the aerobic bottles were negative (145).…”

Section: Rare and Fastidious Organismsmentioning

confidence: 99%

Update on detection of bacteremia and fungemia

1997

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The presence of microorganisms in a patient's blood is a critical determinant of the severity of the patient's illness. Equally important, the laboratory isolation and identification of a microorganism present in blood determine the etiologic agent of infection, especially when the site of infection is localized and difficult to access. This review addresses the pathophysiology and clinical characteristics of bacteremia, fungemia, and sepsis; diagnostic strategies and critical factors in the detection of positive blood cultures; characteristics of manual and instrument approaches to bacteremia detection; approaches for isolating specific microorganisms associated with positive blood cultures; and rapid methods for the identification of microorganisms in blood cultures.

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