“…The synovial tissue in RA is described by prominent hyperplasia, called pannus, which contains pro-inflammatory cytokines [36,63,64] and extents over and under the articular cartilage [62]. In the affected joints, many substances such as tumor necrosis factor (TNF), interleukin-1 (IL-1), fibroblasts, metalloproteinases (MMPs), aggrecanases, and cathepsins are produced [22,54,65,66].…”