Isolation of Karelian Fever Agent From Aedes Communis Mosquitoes

Lvov, D. K.; Skvortsova, T M; Berezina, L. K.; Gromashevsky, V. L.; Yakovlev, B.I.; Gushchin, B V; Аристова, В. А.; Sidorova, G. A.; Gushchina, E.L.; Klimenko, S. M.; L'vov, S D; Khutoretskaya, N. V.; Myasnikova, I. A.; Khizhnyakova, T. M.

doi:10.1016/s0140-6736(84)90562-2

Cited by 38 publications

(23 citation statements)

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“…In Europe, these are Culex pipiens, Culex torrentium (principal enzootic vector in Sweden), Culiseta morsitans, Coquillettidia richiardii, Ochlerotatus communis, Ochlerotatus excrucians, Aedes cinereus, and Anopheles hyrcanus (Berezin et al 1972;Francy et al 1989;Lundström et al 1990a, b;Turell et al 1990;Lvov et al 1984Lvov et al , 1985. Laboratory transmission of SINV was documented also in Aedes albopictus (Dohm et al 1995).…”

Section: Mosquito-borne Human Pathogenic Viruses Autochthonous In Europementioning

confidence: 99%

“…A great input for the study of SINV in Europe has been outbreaks with hundreds of cases in Fennoscandia since 1981 that repeat at about 7-year periodicity (1974, 1981/1982, 1988, 1995, 2002). The disease has been called variably according to the region involved as 'Ockelbo' (Sweden), 'Pogosta' (Finland), or 'Karelian' (NW Russia) fever (Lvov et al 1982(Lvov et al , 1985(Lvov et al , 1988Skogh and Espmark 1982;Espmark and Niklasson 1984;Niklasson et al 1984Niklasson et al , 1988Niklasson and Vene 1996). The average annual incidence of SINV fever in Finland, 1995Finland, -2003, was the highest in North Karelia with 25.7 cases per 100,000 population, while in other parts of the country, it varied between 0.4 and 14.8 cases/100,000 population.…”

Section: Mosquito-borne Human Pathogenic Viruses Autochthonous In Europementioning

confidence: 99%

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Mosquito-borne viruses in Europe

2008

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The number of mosquito-borne viruses ('moboviruses') occurring in Europe since the twentieth century now stands at ten; they belong to three families-Togaviridae (Sindbis, Chikungunya), Flaviviridae (West Nile, Usutu, Dengue), and Bunyaviridae (Batai, Tahyna, Snowshoe hare, Inkoo, Lednice). Several of them play a definite role in human or animal pathology (Sindbis, Chikungunya, Dengue, West Nile, Tahyna). Mobovirus outbreaks are strictly determined by the presence and/or import of particular competent vectors of the disease. Ecological variables affect moboviruses considerably; the main factors are population density of mosquito vectors and their vertebrate hosts, intense summer precipitations or floods, summer temperatures and drought, and presence of appropriate habitats, e.g., wetlands, small water pools, or intravillan sewage systems. A surveillance for moboviruses and the diseases they cause in Europe is recommendable, because the cases may often pass unnoticed or misdiagnosed not only in free-living vertebrates but also in domestic animals and even in humans.

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Section: Mosquito-borne Human Pathogenic Viruses Autochthonous In Europementioning

confidence: 99%

Section: Mosquito-borne Human Pathogenic Viruses Autochthonous In Europementioning

confidence: 99%

Mosquito-borne viruses in Europe

2008

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“…It is not restricted to tropical and subtropical areas of the globe, and infections have occurred in Europe, Africa, Asia, and Australia. SinV is related genetically or antigenically to the viruses isolated from insects or birds during outbreaks of diseases involving joint inflammation [Kurkela et al, 2004], such as Pogosta disease in Finland [Calisher et al, 1985], Ockelbo disease in Sweden [Skogh and Espmark, 1982;Espmark and Niklasson, 1984], and Karelian fever in Russia [Lvov et al, 1984]. Isolation of SinV directly from humans has been reported in South Africa, China, and Finland [Kurkela et al, 2004].…”

Section: Introductionmentioning

confidence: 99%

Pro‐inflammatory response resulting from sindbis virus infection of human macrophages: Implications for the pathogenesis of viral arthritis

Assunção‐Miranda

Bozza

Poian

2009

Journal of Medical Virology

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Several viruses cause acute and chronic joint inflammation in humans, and among them, the alphaviruses are of special interest due to the increasing number of outbreaks in which they are the etiological factor. Sindbis virus (SinV), a member of the Alphavirus genus, is the most widely distributed of all known arboviruses. Although SinV causes arthritis in humans, the molecular and cellular factors that contribute to the pathogenesis of this disease are almost completely unknown. Despite the crucial role of macrophages in the development of arthritis, these cells have not been recognized as potential targets for viruses causing arthritis. In this study, replication of SinV in human macrophages was demonstrated. The infection promoted macrophage activation, leading to the release of macrophage migration inhibitor factor (MIF) from intracellular stores and inducing the expression and secretion of TNF-alpha, IL-1beta, and IL-6. Production of these cytokines was followed by the expression of matrix metalloproteinases (MMPs) 1 and 3, which could be involved in the articular damage that has been observed in disease induced by SinV. The use of different strategies to block MIF action, including an anti-MIF antibody, the MIF inhibitor ISO-1 and knockout mice for the MIF gene, showed that cytokine secretion and MMP expression during infection were regulated by MIF, suggesting that this cytokine acts in autocrine and paracrine manner upstream in the macrophage activation cascade. Thus, these are remarkable similarities between macrophage responses induced by SinV infection and those observed in rheumatoid arthritis, despite the different etiologies of infectious and autoimmune arthritides.

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“…SINV was first isolated from a pool of 63 Culex pipiens and Culex univittatus mosquitoes collected in the Sindbis health district, near Cairo, in 1952 (15) and was further demonstrated to be the causative agent of a febrile illness associated with maculopapular rash and joint pain in humans in Africa, Eurasia (Ockelbo disease, Pogosta disease, and Karelian fever), and Australia (8,9,13). In Europe, the vectors are ornithophilic mosquitoes of the species Culex torrentium, C. pipiens, and Culiseta morsitans, as well as Ochlerotatus spp.…”

mentioning

confidence: 99%