ISOLATION OF<i>CHROMOBACTERIUM PRODIGIOSUM</i>FROM EMPYEMA

Papapanagiotou, J.; Aligizakis, C

doi:10.1136/jcp.12.2.170

Cited by 14 publications

(6 citation statements)

References 7 publications

(1 reference statement)

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“…marcescens was probably the causative agent of a case of empyema in a 55-year-old male patient in Greece with a right spontaneous pneumothorax in 1957. The patient recovered after chloramphenicol treatment (294). In addition, Robinson and Woolley described a case of pseudohemoptysis caused by S. marcescens in 1957 (324).…”

Section: S Marcescensmentioning

confidence: 92%

“…In 1970, Whalen wrote a short letter stating that laboratory manuals of the time still described procedures for applying S. marcescens to hands and then having students shake hands in an attempt to show how microorganisms can be dispersed (406). By the early 1970s, it was becoming clear that S. marcescens could be a pathogen (1,16,34,101,139,144,172,177,294,302,314,324,407), but for years before that, the organism was thought to be a nonpathogen and an ideal tracer organism. In fact, events in the 1970s eventually detailed just how often S. marcescens was used as a tracer organism, and not in just medical experiments.…”

Section: Use In Medical Experimentsmentioning

confidence: 99%

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Serratia Infections: from Military Experiments to Current Practice

2011

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SUMMARY Serratia species, in particular Serratia marcescens , are significant human pathogens. S. marcescens has a long and interesting taxonomic, medical experimentation, military experimentation, and human clinical infection history. The organisms in this genus, particularly S. marcescens , were long thought to be nonpathogenic. Because S. marcescens was thought to be a nonpathogen and is usually red pigmented, the U.S. military conducted experiments that attempted to ascertain the spread of this organism released over large areas. In the process, members of both the public and the military were exposed to S. marcescens , and this was uncovered by the press in the 1970s, leading to U.S. congressional hearings. S. marcescens was found to be a certain human pathogen by the mid-1960s. S. marcescens and S. liquefaciens have been isolated as causative agents of numerous outbreaks and opportunistic infections, and the association of these organisms with point sources such as medical devices and various solutions given to hospitalized patients is striking. Serratia species appear to be common environmental organisms, and this helps to explain the large number of nosocomial infections due to these bacteria. Since many nosocomial infections are caused by multiply antibiotic-resistant strains of S. marcescens , this increases the danger to hospitalized patients, and hospital personnel should be vigilant in preventing nosocomial outbreaks due to this organism. S. marcescens , and probably other species in the genus, carries several antibiotic resistance determinants and is also capable of acquiring resistance genes. S. marcescens and S. liquefaciens are usually identified well in the clinical laboratory, but the other species are rare enough that laboratory technologists may not recognize them. 16S rRNA gene sequencing may enable better identification of some of the less common Serratia species.

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Section: S Marcescensmentioning

confidence: 92%

Section: Use In Medical Experimentsmentioning

confidence: 99%

Serratia Infections: from Military Experiments to Current Practice

2011

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“…It accords with the observations made by other investi-gators. Usually, the strains studied have been sensitive only to neomycin and kanamycin (3,6,8,10,13,16), sometimes also to streptomycin and chloramphenicol (9,12). It is thus understandable that the therapeutic possibilid ties for Serratia marcescens septicema are very limited.…”

Section: Commentsmentioning

confidence: 99%

Serratia Marcescens Septicemia

Reissell¹,

Jansson²

1964

Journal of Internal Medicine

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“…The genus Chromobacterium , consisting of seven recognized species, is a Gram-negative, rod-shaped bacterium, in which the most famous specie is Chromobacterium violaceum with red pigment (Papapanagiotou & Aligizakis, 1959). Chromobacterium is mainly distributed in tropical and subtropical regions, and it is frequently isolated in water sources and humid areas (Blackburn et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Fatal piglets diarrhea caused by a novel Chromobacterium haemolyticum

Zhang

et al. 2022

Preprint

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Chromobacterium haemolyticum is a fatal gram-negative bacterium, which had been found that has the ability to infect human. In this study, we detected a nonpigmented, β-hemolytic gram-negative bacillus from fecal samples of piglets with severe diarrhea and death. Analysis of the 16S rRNA gene sequence indicated it was most closely related to Chromobacterium haemolyticum, however only with 79% identities, indicating that this bacterium may be a new type of Chromobacterium haemolyticum. Diarrhea was reproduced in experimental pigs with one of the isolates strains, designated GDHYZ30 strain. Intramuscular injection of the GDHYZ30 strain can cause death of the piglets, and irrigated challenge induced piglets diarrhea. To further elucidate the mechanism of pathogensis of this bacterium, whole genome sequencing was used to analyze and annotate the GDHYZ30 strain. The full-length genome of the strain was 4785117bp, the G+C content was 62.67%, and it encoded 4398 genes, in which 57 drug resistance genes, and 390 virulence factors were included. It is worth noting that this novel Chromobacterium haemolyticum has been isolated from several other pig farm water samples and pig feces samples with unexplained diarrhea. To our knowledge this is the first report that a novel Chromobacterium haemolyticum as a new pathogen causing diarrhea and death in piglets and transmiting through water sources. And the genetic characteristics of the bacteria are analyzed by whole gene sequencing, which provides a reference for the prevention of human and animal infections and food safety.

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ISOLATION OFCHROMOBACTERIUM PRODIGIOSUMFROM EMPYEMA

Cited by 14 publications

References 7 publications

Serratia Infections: from Military Experiments to Current Practice

Serratia Infections: from Military Experiments to Current Practice

Serratia Marcescens Septicemia

Fatal piglets diarrhea caused by a novel Chromobacterium haemolyticum

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