Isolation of fibronectin type III like peptide from human placental extract used as wound healer

Chakraborty, Piyali Datta; Bhattacharyya, Debasish

doi:10.1016/j.jchromb.2004.09.059

Cited by 51 publications

(43 citation statements)

References 22 publications

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“…Placenta is also rich in elastin, which provide elasticity to the skin and recoils to tissues like a spring undergoing repeated stretch [39,42]. Besides, fibronectin, important for the maintenance of normal cell morphology, cell migration; and laminin, which play a role in cells attachment, differentiation and tissue survival are also detected in human placental extracts [43][44][45].…”

Section: Extracellular Matrix Componentsmentioning

confidence: 99%

Placental therapy: An insight to their biological and therapeutic properties

Pan¹,

Chan²,

Wong³

et al. 2017

J Med Therap

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The placenta, supporting the growth and development of the fetus, are rich in amino acids, peptides, vitamins, trace elements and growth factors, nutrients and biological active components. Placental therapy was applied to promote from the recovery of diseases and tissue regeneration since the early 1900s. Since then, placental therapy was applied in various clinical applications as they were shown to exhibit remarkable therapeutic attributes ranging from anti-oxidant, antimicrobial, anti-inflammatory, pain reduction, hair growth promotion, health improvement, cellular proliferation, tissue regeneration and wound healing properties in vivo. This review further summarizes the historical aspects, cellular mechanism, nutrient content and therapeutics properties of the placenta.

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Section: Extracellular Matrix Componentsmentioning

confidence: 99%

Placental therapy: An insight to their biological and therapeutic properties

Pan¹,

Chan²,

Wong³

et al. 2017

J Med Therap

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“…Aqueous extract from placenta is used as a licensed drug for wound healing under different trade names in India and overseas countries (Datta and Bhattacharyya, 2004a). This could be due the fact that the aqueous extract is a rich source of various bioactive peptides with tissue regeneration potential (Chakraborty and Bhattacharyya, 2005a;De et al, 2009). In addition, the extract also retains amino acids, nucleotides, polydeoxyribonucleotides and carbohydrates that might be responsible for wound healing.…”

Section: Role Of Placental Extract In Wound Healingmentioning

confidence: 99%

“…The importance of fibronectin in cutaneous wound healing is well documented as a general cell adhesion molecule by promoting the spread of platelets at the site of injury. It also helps in the adhesion and migration of neutrophils, monocytes, fibroblasts and endothelial cells into the wound region, and the migration of epidermal cells through the granulation tissue (Chakraborty and Bhattacharyya, 2005a).…”

Section: Biochemical Characterization and Possible Mechanism Of Actiomentioning

confidence: 99%

Aqueous Extract of Human Placenta

Chakraborty¹,

Bhattacharyya²

2012

Recent Advances in Research on the Human Placenta

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“…HPE efficiently activates adenosine A2A receptors and is not degraded in vivo, meaning it is more efficient than other types of therapy, including vacuum sealing drainage, local application of growth factor, and traditional Chinese medicine (3). However, the use of appropriate vehicles to maintain the biological activity of HPE during the delivery process is crucial to the success of the treatment (4,5).…”

Section: Introductionmentioning

confidence: 99%

Preparation of a novel composite nanofiber gel-encapsulated human placental extract through layer-by-layer self-assembly

Liu

Chen

Zhou

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. Aqueous human placenta extract (HPE) has been previously used to treat chronic soft tissue ulcer; however, the optimal dosage of HPE has yet to be elucidated. The present study investigated a novel nanofiber gel composed through layer-by-layer (LbL) self-assembly, in which HPE was encapsulated. IKVAV, RGD, RAD16 and FGL-PA were screened and combined to produce an optimal vehicle nanofiber gel through LbL assembly. Subsequently, the aqueous HPE was encapsulated into this nanofiber at the appropriate concentration, and the morphology, particle size, drug loading efficacy, encapsulation rate, release efficiency and structure validation were detected. The encapsulation efficiency of all three HPE samples was >90%, the nanofiber gel exhibited a slow releasing profile, and the structure of HPE encapsulated in the nanofiber gel was unvaried. In conclusion, this type of novel composite nanocapsules may offer a promising delivery system for HPE.

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Isolation of fibronectin type III like peptide from human placental extract used as wound healer

Cited by 51 publications

References 22 publications

Placental therapy: An insight to their biological and therapeutic properties

Placental therapy: An insight to their biological and therapeutic properties

Aqueous Extract of Human Placenta

Preparation of a novel composite nanofiber gel-encapsulated human placental extract through layer-by-layer self-assembly

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