Isolation of Endophytic Bacteria, Bioactive Compounds and Its Antiviral Activity Against Herpes Simplex Virus Type -1

Abstract

Microbial community has been a major part in the drug industry. They are known for their effectiveness and do not cause any undesirable effects. Exploitation of bacteria could be fruitful for mankind. Bacteria play a major role in producing useful bioactive compounds. HSV-1 infection causes 80% of oral lesions. A majority of the population is infected by at least one herpes subtype of HSV-1 before adulthood. The infection in some cases does not produce any symptoms. Drugs for HSV-1 are becoming suppressive. In the present study, isolation of endophytic bacteria was carried out from medicinal plant. A grown bacterium was identified and confirmed using molecular 16S rRNA sequencing followed by extraction of bioactive compounds using solvents. Twelve bioactive compounds were then investigated for in vitro cytotoxicity assay and in vitro antiviral assay. Chloroform extract was found to be effective in inhibiting the virus.

Systematic Review on Thiazole Compounds as Nanoparticles: Chemistry, Synthesis, Antimicrobial Activities, Therapeutic Investigation

“…Thiazole is an important aromatic containing sulphur and nitrogen atoms as a part of five-membered heterocyclic ring with the molecular formula of C 3 H 3 NS and molecular weight of 85.128 gmole 1 (Figs. 1,2). That thiazole is yellow in colour and is liquid in state.…”

“…This study has indicated that thiazole-possessing compound 14 remarkably decreased the neurotoxicity induced by ROS at 10 µM concentrations. In addition, the mentioned compound showed the best lipid peroxidation (LPO) inhibition and in vivo neuroprotective activities using gerbils as animal models [117,118]: (13), (14). Thiazole derivatives and related compounds reported as antioxidant agents.…”

“…A heterocyclic compound is one that possesses a cyclic structure with at least two different kinds of heteroatoms in the ring [1,2], considered to be aromatic as it follows the Hückel's rule [3].…”

“…On the other hand, the thiazole ring is present in various marine or terrestrial natural compounds that have useful biological activities [10][11][12][13]. In the recent years, experimental researches have introduced some thiazole derivatives as the multitherapeutic effect compounds including anticancer, anti-inflammatory, and inhibitor of the parasites like Leishmania and the fungi such as Candida [14][15][16][17].…”