2002
DOI: 10.1897/1551-5028(2002)021<1359:iocfbk>2.0.co;2
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Isolation of Compounds From Bleached Kraft Mill Recovery Condensates Associated With Reduced Levels of Testosterone in Mummichog (Fundulus Heteroclitus)

Abstract: Previous studies have identified chemical recovery condensates as a primary source of hormonally active substances within a Canadian bleached kraft pulp mill. Although reverse osmosis treatment of condensates raises the exposure threshold that alters circulating levels of testosterone in mummichog (Fundulus heteroclitus), the responsible chemicals have not been characterized. In this study, a solid-phase extraction (SPE) method was developed to isolate chemical recovery condensate extractives for evaluation of… Show more

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Cited by 15 publications
(34 citation statements)
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“…Testosterone was unaffected in male and female mummichog Table 2. Testosterone depressions were observed in male and female mummichog exposed for 30 or 60 d to 50% CME following installation of a reverse-osmosis effluent treatment system [27,33] and in females at 1 and 50% concentrations [26]. b Females (F) exposed to 3% effluent weighed significantly more than did controls ( p 5 0.02).…”
Section: Discussionmentioning
confidence: 98%
“…Testosterone was unaffected in male and female mummichog Table 2. Testosterone depressions were observed in male and female mummichog exposed for 30 or 60 d to 50% CME following installation of a reverse-osmosis effluent treatment system [27,33] and in females at 1 and 50% concentrations [26]. b Females (F) exposed to 3% effluent weighed significantly more than did controls ( p 5 0.02).…”
Section: Discussionmentioning
confidence: 98%
“…Toxicol. Canadian kraft bleached mill condensates (condensed vapor produced when black liquor is concentrated in evaporators as part of the chemical recovery process) were solid-phase extracted (similar to the methods used in our experiment) and used to evaluate the association with testosterone reduction in a waterborne exposure experiment using adult male and prespawning female mummichog (Fundulus heteroclitus) [36]. 28, 2009 187 that provide mechanistic data, the high variability and discrepancies in relative potency of the in vitro tests seem to be associated with the lower level of biological organization used in each assay, thus having an intrinsic limitation in trying to elucidate environmentally relevant effects [8,33].…”
Section: Discussionmentioning
confidence: 99%
“…As well, basal steroid levels were often at the detection limits of the RIA. Medium 199 has been shown to be an effective medium for gonadal incubations in this species [10; this study] and the incubation requirements have been further optimized here from that earlier work. Basal testes testosterone production generally yields testosterone levels at or below 1 pg/mg tissue/h [9,10; this study, Fig.…”
Section: Discussionmentioning
confidence: 99%