1999
DOI: 10.1095/biolreprod61.2.372
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Isolation of Complementary Deoxyribonucleic Acids Encoding Putative Secreted and Membrane-Bound Folate Binding Proteins from Endometrium of Swine1

Abstract: Two distinct forms of endometrial folate binding protein (FBP) cDNAs were isolated using reverse transcription-polymerase chain reaction and 3' and 5' rapid amplification of cDNA ends (RACE) procedures. On the basis of the absence or presence of an intact glycophosphatidylinositol linkage site in the C terminus of the predicted amino acid sequences, the two forms appear to encode secreted and membrane-bound forms of FBP. The cDNAs for the putative secreted and membrane forms encoded 252- and 249-amino acid pro… Show more

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Cited by 10 publications
(35 citation statements)
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“…While folate binding in the uterine flushings increased on Days 13 and 15 of the estrous cycle and pregnancy in this study and in previous studies [14,15], endometrial expression of sFBP mRNA did not change between Days 10 and 15 [16]. Increased intrauterine content of sFBP was hypothesized to be due either to the release of stored sFBP from the endometrium or increased translation of sFBP mRNA [16].…”
Section: Discussioncontrasting
confidence: 56%
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“…While folate binding in the uterine flushings increased on Days 13 and 15 of the estrous cycle and pregnancy in this study and in previous studies [14,15], endometrial expression of sFBP mRNA did not change between Days 10 and 15 [16]. Increased intrauterine content of sFBP was hypothesized to be due either to the release of stored sFBP from the endometrium or increased translation of sFBP mRNA [16].…”
Section: Discussioncontrasting
confidence: 56%
“…Finally, two pig membrane-bound folate receptors are known [16,27]. One was cloned from pig endometrium [16] and the other from pig liver [27]. It is possible that the binding sites reported here are the result of expression of more than one folate receptor gene and that the relationship between the expression of the different folate receptor genes changes during late pregnancy.…”
Section: Discussionmentioning
confidence: 91%
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