Isolation of Circulating Melanoma Cells

Ma, Jie; Frank, Markus H.

doi:10.1007/7651_2015_300

Cited by 6 publications

(5 citation statements)

References 19 publications

(32 reference statements)

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“…CMCs express a variety of surface antigens used in various isolation and detection techniques, including melanoma cell markers, e.g., MCAM (melanoma cell adhesion molecule, MCAM/MUC18/CD146) [ 25 ], MART-1 (melanoma antigen recognized by T cells 1/Melan-A) [ 29 ], MAGE-A3 (melanoma antigen A3), PAX3 (paired box 3), HMW-MAA (human high-molecular weight melanoma-associated antigen) [ 30 ] and GM2/GD2 (gangliosides) [ 31 ]. Importantly, none of the mentioned antigens’ expression is restricted to melanoma cells.…”

Section: Liquid Biopsy In Melanomamentioning

confidence: 99%

Liquid Biopsy in Melanoma: Significance in Diagnostics, Prediction and Treatment Monitoring

Kamińska

Buszka

Zabel

et al. 2021

IJMS

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Liquid biopsy is a common term referring to circulating tumor cells and other biomarkers, such as circulating tumor DNA (ctDNA) or extracellular vesicles. Liquid biopsy presents a range of clinical advantages, such as the low invasiveness of the blood sample collection and continuous control of the tumor progression. In addition, this approach enables the mechanisms of drug resistance to be determined in various methods of cancer treatment, including immunotherapy. However, in the case of melanoma, the application of liquid biopsy in patient stratification and therapy needs further investigation. This review attempts to collect all of the relevant and recent information about circulating melanoma cells (CMCs) related to the context of malignant melanoma and immunotherapy. Furthermore, the biology of liquid biopsy analytes, including CMCs, ctDNA, mRNA and exosomes, as well as techniques for their detection and isolation, are also described. The available data support the notion that thoughtful selection of biomarkers and technologies for their detection can contribute to the development of precision medicine by increasing the efficacy of cancer diagnostics and treatment.

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Section: Liquid Biopsy In Melanomamentioning

confidence: 99%

Liquid Biopsy in Melanoma: Significance in Diagnostics, Prediction and Treatment Monitoring

Kamińska

Buszka

Zabel

et al. 2021

IJMS

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“…Analysis of some clinical data demonstrated that overexpression of ABCB5 can promote tumor progression, and that ABCB5 expression is usually low in pigmented nevus subpopulation but high in primary and metastatic melanoma cell subpopulation (37,44). In serial human-to-mouse xenotransplantation experiments, ABCB5 + melanoma cells possess greater tumorigenic capacity than ABCB5bulk populations (44,45). Ma and Frank (45) reported that ABCB5 + melanoma cells exist in the peripheral blood of patients with melanoma.…”

Section: Melanoma Metastasis Is Modulated By Molecular Markers Of Mscsmentioning

confidence: 99%

“…In serial human-to-mouse xenotransplantation experiments, ABCB5 + melanoma cells possess greater tumorigenic capacity than ABCB5bulk populations (44,45). Ma and Frank (45) reported that ABCB5 + melanoma cells exist in the peripheral blood of patients with melanoma. Subsequently, transplanting these cells to Nod/SCID/IL2 mice can induce distant metastasis, and the degree of metastasis is directly proportional to the number of ABCB5 + melanoma cells transplanted.…”

Section: Melanoma Metastasis Is Modulated By Molecular Markers Of Mscsmentioning

confidence: 99%

Effect of melanoma stem cells on melanoma metastasis (Review)

et al. 2021

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Cancer stem cells (CSCs) are involved in the metastatic process, the resistance of many types of cancer to therapeutic treatments and consequently the onset of recurrences. The CSC concept therefore significantly extends our understanding of melanoma biology. More recently, melanoma stem cells (MSCs) have been described in melanoma as expressing specific biomarkers. These primitive melanoma cells are not only capable of self-renewal and differentiation plasticity, but may also confer virulence via immune evasion and multidrug resistance, and potentially, via vasculogenic mimicry and transition to migratory and metastasizing derivatives. This review will present the specific biomarkers of MSCs, including CD133, ATP binding cassette subfamily B member 5, CD271, CD20 and aldehyde dehydrogenase, which can regulate the transduction of tumor-related signals. These signal molecules can reversely act on tumor cells and regulate tumor angiogenesis, leading to the occurrence of melanoma metastasis. Targeting these specific biomarkers could inhibit the progression of melanoma and may help the development of novel therapeutic strategies for melanoma. Contents1. Introduction 2. Melanoma metastasis is modulated by molecular markers of melanoma stem cells 3. Melanoma stem cells and angiogenesis 4. Targeting molecular markers of melanoma stem cells 5. Conclusion

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“…Это позволяет предположить, что АВС-транспортеры, возможно, участвуют в регуляции «стволового фенотипа» клеток, поддерживая их популяцию [46]. В целом ряде клинических исследований по изучению роли транспортного белка ABCB5 ученые установили, что гиперэкспрессия ОСК меланомы транспортера ABCB5 строго коррелирует с опухолевой прогрессией, развитием рецидивов и лекарственной резистентности [43,[47][48][49][50]. Кроме того, выраженная экспрессия медиатора ассоциирована с клоногенетическим потенциалом клеток меланомы in vitro [51][52][53].…”

Section: лекарственная резистентность и опухолевые стволовые клеткиunclassified

The role of tumor stem cells in the development of drug resistance of melanoma

Chulkova

Маркина²,

Чернышева³

et al. 2019

Rossijskij bioterapevtičeskij žurnal

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Despite the fact that melanoma is a tumor of visual localization, mortality from skin melanoma remains one of the leading causes of mortality worldwide. Early metastasis of melanoma, even during the initial stages of the tumor process, indicates a high malignant potential of the tumor. Moreover, metastatic melanoma is resistant to current chemotherapy regimens, which is a significant problem today. Progression, resistance to drug therapy of skin melanoma is associated with a population of tumor stem cells, which are characterized by dysregulation of signaling pathways and aberrant phenotypes. The formation of tumor stem cells contributes to their microenvironment. Surface markers expressed by tumor stem cells include transporter proteins that mediate chemoresistance. The study of the microenvironment, the activity of the expressed antigenic determinants makes it possible to understand the processes of chemoresistance formation and to discover (develop) strategies for its overcoming. The article provides an analysis of the literature data on the significance of tumor stem cells in the development of drug resistance of melanoma.

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Isolation of Circulating Melanoma Cells

Cited by 6 publications

References 19 publications

Liquid Biopsy in Melanoma: Significance in Diagnostics, Prediction and Treatment Monitoring

Liquid Biopsy in Melanoma: Significance in Diagnostics, Prediction and Treatment Monitoring

Effect of melanoma stem cells on melanoma metastasis (Review)

The role of tumor stem cells in the development of drug resistance of melanoma

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