Isolation of Chlamydia abortus from a laboratory worker diagnosed with atypical pneumonia

Ortega, Nieves; Caro, M.R.; Gallego, María Soledad Carrillo; Murcia-Belmonte, A.; Álvarez, D.; Rı́o, Laura Del; Cuello, F.; Buendía, A. J.; Salinas, J.

doi:10.1186/s13620-016-0067-4

Cited by 33 publications

(29 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recently, a case of an atypical pneumonia due to C. abortus in a laboratory worker involved in intranasal experimental C. abortus infections in sheep was reported. 112 C. abortus strains within Europe, in contrast to C. suis strains, have a limited diversity but strong geographical signatures. They do not harbor a plasmid and recombination was not identified in a recent study.…”

Section: Chlamydia Abortus In Ruminants and Other Hostsmentioning

confidence: 98%

A Review on Chlamydial Diseases in Animals: Still a Challenge for Pathologists?

2018

View full text Add to dashboard Cite

Chlamydiae have a worldwide distribution causing a wide range of diseases in human hosts, livestock, and companion animals as well as in wildlife and exotic species. Moreover, they can persist in their hosts as asymptomatic infections for extended periods of time. The introduction of molecular techniques has revolutionized the Chlamydia field by expanding the host range of known chlamydial species but also by discovering new species and even new families of bacteria in the broader order Chlamydiales. The wide range of hosts, diseases, and tissues affected by chlamydiae complicate the diagnosis such that standard diagnostic approaches for these bacteria are rare. Bacteria of the Chlamydiales order are small and their inclusions are difficult to detect by standard microscopy. With the exception of avian and ovine chlamydiosis, macroscopic and/or histologic changes might not be pathognomic or indicative for a chlamydial infection or even not present at all. Moreover, detection of chlamydial DNA in specimens in the absence of other methods or related pathological lesions questions the significance of such findings. The pathogenic potential of the majority of recently identified Chlamydia-related bacteria remains largely unknown and awaits investigation through experimental or natural infection models including histomorphological characterization of associated lesions. This review aims to summarize the historical background and the most important developments in the field of animal chlamydial research in the past 5 years with a special focus on pathology. It will summarize the current nomenclature, present critical thoughts about diagnostics, and give an update on chlamydial infections in domesticated animals such as livestock, companion animals and birds, as well as free-ranging and captive wild animals such as reptiles, fish, and marsupials.

show abstract

Section: Chlamydia Abortus In Ruminants and Other Hostsmentioning

confidence: 98%

A Review on Chlamydial Diseases in Animals: Still a Challenge for Pathologists?

2018

View full text Add to dashboard Cite

show abstract

“…The extragestational infection of C. abortus manifested as PID has also been described [7]. More recently, atypical pneumonia related to C. abortus has been reported in Spain [6].…”

Section: Introductionmentioning

confidence: 99%

Chlamydiaceae: Diseases in Primary Hosts and Zoonosis

et al. 2019

View full text Add to dashboard Cite

Bacteria of the Chlamydiaceae family are a type of Gram-negative microorganism typified by their obligate intracellular lifestyle. The majority of the members in the Chlamydiaceae family are known pathogenic organisms that primarily infect the host mucosal surfaces in both humans and animals. For instance, Chlamydia trachomatis is a well-known etiological agent for ocular and genital sexually transmitted diseases, while C. pneumoniae has been implicated in community-acquired pneumonia in humans. Other chlamydial species such as C. abortus, C. caviae, C. felis, C. muridarum, C. pecorum, and C. psittaci are important pathogens that are associated with high morbidities in animals. Importantly, some of these animal pathogens have been recognized as zoonotic agents that pose a significant infectious threat to human health through cross-over transmission. The current review provides a succinct recapitulation of the characteristics as well as transmission for the previously established members of the Chlamydiaceae family and a number of other recently described chlamydial organisms.

show abstract

“…C. abortus infection has also been associated with reproductive problems in large ruminants [2, 3], and the variety of species in which the pathogenic action of C. abortus has been demonstrated is very large, ranging from Canidae [4] to Delphinidae [5]. In addition, C. abortus is potentially a professional zoonosis [6]. A particularly interesting feature of ovine enzootic abortion is the establishment of latent infections, since the infection remains unapparent in the non-pregnant animal and only becomes evident during a subsequent pregnancy [7].…”

Section: Introductionmentioning

confidence: 99%

Effect of female sex hormones on the developmental cycle of Chlamydia abortus compared to a penicillin-induced model of persistent infection

et al. 2019

View full text Add to dashboard Cite

Background Chlamydia abortus , an obligate intracellular pathogen with an affinity for placenta, causes reproductive failure. In non-pregnant animals, an initial latent infection is established until the next gestation, when the microorganism is reactivated, causing abortion. The precise mechanisms that trigger the awakening of C. abortus are still unknown. Sexual hormones such as estradiol and progesterone have been shown to affect the outcome of infection in other species of the family Chlamydiaceae, while estrogens increase chlamydial infection, progesterone has the opposite effect. To try to establish whether there is a relationship between these events and the latency/ reactivation of C. abortus in the reproductive tract of small ruminants, ovine endometrial (LE) and trophoblastic (AH-1) cells were treated with estradiol or progesterone prior to their infection with C. abortus . The results are compared with those obtained for treatment with penicillin prior to infection, which is a well-established model for studying persistent infection in other chlamydial species. Cells were examined by transmission electron microscopy, and an mRNA expression analysis of 16 genes related to the chlamydial developmental cycle was made. Results The changes observed in this study by the action of sex hormones seem to depend on the type of cell where the infection develops. In addition, while the changes are morphologically similar to those induced by treatment with penicillin, the patterns of gene expression are different. Gene expression patterns therefore, seem to depend on the persistence induced models of C. abortus used. Hormone treatments induced aberrant forms in infected endometrial cells but did not affect the chlamydial morphology in trophoblast cells. At the genetic level, hormones did not induce significant changes in the expression of the studied genes. Conclusions The results suggest that penicillin induces a state of persistence in in vitro cultured C. abortus with characteristic morphological features and gene transcriptional patterns. However, the influence of hormones on the C. abortus developmental cycle is mediated by changes in the host cell environment. Furthermore, a persistent state in C. abortus cannot be characterised by a single profile of gene expression pattern, but may change depending on the model used to induce persistence.

show abstract

Isolation of Chlamydia abortus from a laboratory worker diagnosed with atypical pneumonia

Cited by 33 publications

References 18 publications

A Review on Chlamydial Diseases in Animals: Still a Challenge for Pathologists?

A Review on Chlamydial Diseases in Animals: Still a Challenge for Pathologists?

Chlamydiaceae: Diseases in Primary Hosts and Zoonosis

Effect of female sex hormones on the developmental cycle of Chlamydia abortus compared to a penicillin-induced model of persistent infection

Contact Info

Product

Resources

About