Isolation of Chitin from a Variety of Raw Materials, Modification of the Material, and Interaction its Derivatives with Metal Ions

Рашидова, С. Ш.; Milusheva, R. Yu.; Voropaeva, N. L.; Nikonovich, G. V.; Ruban, I. N.

doi:10.1365/s10337-004-0290-0

Cited by 15 publications

(7 citation statements)

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“…It is the second most abundant natural polymer on earth next to cellulose and is crystalline in nature [2]. The three polymorphic crystalline forms of chitin are ␣, ␤ and ␥ [3,4]. These forms of chitin differ from one another based on the arrangement of polymer chains.…”

Section: Introductionmentioning

confidence: 99%

“…The polymer chains are arranged antiparallel to each other in ␣-chitin, parallel to each other in ␤-chitin whereas randomly in ␥-chitin. These polymer chains are tightly held by intermolecular hydrogen bonding between N H and C O functional groups [4]. Chitin, from the biomedical point of view has several advantages like biodegradability [5], biocompatibility, non-toxicity, [6] promotes mineralization (calcification) [7], etc.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, characterization and cytocompatibility studies of α-chitin hydrogel/nano hydroxyapatite composite scaffolds

Kumar

Srinivasan

Tamura

et al. 2011

International Journal of Biological Macromolecules

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and cytocompatibility studies of α-chitin hydrogel/nano hydroxyapatite composite scaffolds

Kumar

Srinivasan

Tamura

et al. 2011

International Journal of Biological Macromolecules

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“…Chitosan Bombyx mori with a degree of deacetylation of 88–96% (eq 1 of Supporting Information) and a molecular mass M w of 151.8–418.0 kDa (Table S1 of Supporting Information) was synthesized from chitin Bombyx mori by heterogenic deacetylation . Poly(ethylene glycol) monomethyl ether (MPEG) ( M w 2000) was purchased from Sigma Aldrich or Fluka.…”

Section: Methodsmentioning

confidence: 99%

“…Chitosan Bombyx mori with a degree of deacetylation of 88−96% (eq 1 of Supporting Information) and a molecular mass M w of 151.8−418.0 kDa (Table S1 of Supporting Information) was synthesized from chitin Bombyx mori by heterogenic deacetylation. 35 Poly(ethylene glycol) monomethyl ether (MPEG) (M w 2000) was purchased from Sigma Aldrich or Fluka. Bodipy (Invitrogen; M w : 660.5 Da; E max = 630 nm), sodium fluorescein (Fluka Chemika; M w : 376.3 Da; E max = 514 nm), isothiocyanate conjugate of bovine albumin (BSA−FITC) (M w = 66 kDa), and all the solvents were used without further purification.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

The Amine Content of PEGylated Chitosan Bombyx mori Nanoparticles Acts as a Trigger for Protein Delivery

et al. 2014

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In modern medicine, effective protein therapy is a major challenge to which a significant contribution can be expected from nanoscience through the development of novel delivery systems. Here we present the effect of the amine content of nanoparticles based on PEGylated chitosan Bombyx mori (PEG-O-ChsBm) copolymers on the entrapment of molecules in a search for highly efficient nanocarriers. PEG-O-ChsBm copolymers were synthesized with amine contents from 1.12% to 0.70%, and nanoparticles were generated by self-assembly in dilute aqueous solutions. These nanoparticles successfully entrapped molecules with a wide range of sizes, the efficiency of which was dependent on their amine contents. While hydrophobic molecules were entrapped with high efficiency in all types of nanoparticle, hydrophilic molecules were entrapped only in those with low amine content. Bovine serum albumin, selected as a model protein, was entrapped in nanoparticles and efficiently released in acidic conditions. The triggered entrapment of molecules in PEG-O-ChsBm nanoparticles by selection of the appropriate amine content represents a straightforward way to modulate their delivery by fine changes in the properties of nanocarriers.

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“…Therefore, a series of pretreatments are necessary to remove the impurities before isolation. There are four critical steps involves nanochitin isolation, that is i) remove residual proteins by alkaline or enzymatic hydrolysis; ii) remove inorganic salts by HCl aqueous solution; iii) extract astaxanthin pigments and lipids with organic solvents; iv) obtain white chitin products through treatment of residues. In this review, we introduced four typical methods to nanochitin isolation, that is, acid hydrolysis, TEMPO‐mediated oxidation, partial deacetylation and mechanical isolation.…”

Section: Top‐down Isolation Techniquesmentioning

confidence: 99%

Nanobiopolymers Fabrication and Their Life Cycle Assessments

Yang

Zhang

et al. 2018

Biotechnology Journal

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Living organisms produced nanopolymers (nanobiopolymers for short), such as nanocellulose, nanochitin, nanosilk, nanostarch, and microbial nanobiopolymers, having received widely scientific and engineering interests in recent years. Compare with petroleum-based polymers, biopolymers are sustainable and biodegradable. The unique structural features that stem from nanosized effects, such as ultrahigh aspect ratio and length-diameter ratio, further endow nanobiopolymers with high transparence and versatile processability. To fabricate these nanobiopolymers, a variety of mechanical, chemical, and synthetic biology techniques have been developed. The applications of the isolated nanobiopolymers have been extended from polymer fillers into wide emerging high-tech fields, such as biomedical devices, bioplastics, display panels, ultrafiltration membranes, energy storage devices, and catalytic supports. Accordingly, in the review, the authors first introduce isolation techniques to fabricate nanocellulose, nanochitin, nanosilk, and nanostarch. Then, the authors summarized the nanobiopolymers produced from biosynthetic pathway, including microbial polyamides, polysaccharides, and polyesters. On the other hand, most of these techniques require high energy consumption and usage of chemical reagents. In this regard, life cycle assessment offered a quantitative route to precisely evaluate and compare environmental benefits of different artificial isolation approaches, which are also summarized in the second section of the review.

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Isolation of Chitin from a Variety of Raw Materials, Modification of the Material, and Interaction its Derivatives with Metal Ions

Cited by 15 publications

References 0 publications

Synthesis, characterization and cytocompatibility studies of α-chitin hydrogel/nano hydroxyapatite composite scaffolds

Synthesis, characterization and cytocompatibility studies of α-chitin hydrogel/nano hydroxyapatite composite scaffolds

The Amine Content of PEGylated Chitosan Bombyx mori Nanoparticles Acts as a Trigger for Protein Delivery

Nanobiopolymers Fabrication and Their Life Cycle Assessments

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