Isolation of cells from the lower airways in infants with wheeze by sputum induction

Gaillard, Erol; Grigg, Jonathan; Tellabati, Ananth; McNally, Teresa; Whittaker, Amy; Beardsmore, Caroline

doi:10.1183/09031936.00160412

Cited by 6 publications

(11 citation statements)

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“…Although the safety of sputum induction and utility for bacterial infection in preschool children has been established, to our knowledge our data are the first combining several aspects; safety, feasibility, quality (both for culture and cytology) in a range of chronic airway diseases in preschool children. Most previous studies have included a small sample size ranging from 6 up to 20 and although the age range has been from 7 months, studies have not been restricted to preschool age and have included children aged up to 8 years …”

Section: Discussionmentioning

confidence: 99%

“…Respiratory rate (recorded over 1 min) and findings on auscultation were documented. Salbutamol administered via metered dose inhaler and spacer (200 mcg for children with no history of wheeze, or 500 mcg for those with wheeze) was administered 15 min prior to commencement of sputum induction.…”

Section: Methodsmentioning

confidence: 99%

“…Hypertonic saline was nebulized through an ultrasonic nebuliser (DeVILBLISS Ultraneb) 7% saline (Nebusal 4 ml ampoules) was used in patients with cystic fibrosis (suri;2003) or in any child with chronic suppurative lung disease already prescribed nebulized hypertonic saline as part of their routine clinical care. Three point five percentage saline was used in patients with wheeze or an unconfirmed diagnosis. A facemask was used to deliver the saline for three cycles of 5 min .…”

Section: Methodsmentioning

confidence: 99%

“…Induced sputum has also been adopted for use in infants and young children to detect infections such as tuberculosis . Successful sputum induction has been reported in six infants aged between 6 months and 2 years with wheezing and samples were of sufficient quality to obtain inflammatory cell counts. However, most children required sedation for the procedure.…”

Section: Introductionmentioning

confidence: 99%

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Infection and inflammation in induced sputum from preschool children with chronic airways diseases

Jochmann

Artusio

Robson

et al. 2015

Pediatric Pulmonology

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IS from preschool children can be used to assess infection. BAL and IS culture concurred in approximately two-thirds. However, inflammation was measureable in only one-third of IS samples and the cell differential was predominantly neutrophilic compared to BAL. Blood eosinophils may provide a better reflection of lower airway eosinophilia in this age group. Pediatr Pulmonol. 2016;51:778-786. © 2015 WileyPeriodicals, Inc.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Infection and inflammation in induced sputum from preschool children with chronic airways diseases

Jochmann

Artusio

Robson

et al. 2015

Pediatric Pulmonology

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“…Whether eosinophilic inflammation plays a pathophysiological role in TVW remains unclear, due to difficulties in obtaining sputum from preschool children [9]. Little is known about the natural course of such inflammatory changes after the symptoms have resolved.…”

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confidence: 99%

Airway eosinophils in older teenagers with outgrown preschool wheeze: a pilot study

et al. 2015

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Preschool wheezing affects one-third of all children growing up in the UK [1]. It varies in clinical presentation and severity, and there is evidence to suggest the co-existence of different wheeze phenotypes [2], some of which have been associated with adult asthma and chronic obstructive pulmonary disease [3]. Using data from the Leicester Respiratory Cohort studies [4], we have previously applied objective data-driven methods to distinguish three distinct preschool wheeze phenotypes: "atopic" and "non-atopic" persistent wheeze (PW) and transient viral wheeze (TVW) [5]. In children with PW, attacks of wheeze with and without colds were observed both at preschool age (0-5 years) and when followed-up at early school-age (4-8 years). Children with TVW, triggered predominantly by colds, had symptoms at age 0-5 years but not at age 4-8 years. Prognosis 5 years later (aged 8-13 years) was markedly better in children with TVW compared to the two PW phenotypes [6].

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Enigma variations: The multi‐faceted problems of pre‐school wheeze

Chatziparasidis

Bush

2022

Pediatric Pulmonology

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Numerous publications on wheezing disorders in children younger than 6 years have appeared in the medical literature over the last decades with the aim of shedding light on the mechanistic pathways (endotypes) and treatment. Nevertheless, there is yet no consensus as to the appropriate way to manage preschool wheeze mainly because of the lack of a clear definition of "preschool asthma" and the paucity of scientific evidence concerning its underlying endotypes. A symptom-based approach is inadequate since the human airway can respond to external stimuli with a limited range of symptoms and signs, including cough and wheeze, and these manifestations represent the final expression of many clinical entities with potentially different pathophysiologies requiring different individualized treatments. Hence, new studies challenge the symptom-based approach and promote the importance of managing the wheezy child based on the "airway phenotype." This will enable the clinician to identify not only the child with a serious underlying pathology (e.g., a structural airway disorder or immunodeficiency) who is in need of prompt and specific treatment but also increase the specificity of treatment for the child with symptoms suggestive of an "asthma" syndrome. In the latter case, focus should be given to the identification of treatable traits. This review summarizes the current understanding in management of preschool wheezing and highlights the unmet need for further research.

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Isolation of cells from the lower airways in infants with wheeze by sputum induction

Cited by 6 publications

References 10 publications

Infection and inflammation in induced sputum from preschool children with chronic airways diseases

Infection and inflammation in induced sputum from preschool children with chronic airways diseases

Airway eosinophils in older teenagers with outgrown preschool wheeze: a pilot study

Enigma variations: The multi‐faceted problems of pre‐school wheeze

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