Isolation of Burkholderia cenocepacia J 2315 from non-cystic fibrosis pediatric patients in India

Satpute, Meenakshi; Telang, Nilima; Dhakephalkar, Prashant K.; Niphadkar, Krishna B.; Joshi, Suresh G.

doi:10.1016/j.ajic.2010.10.034

Cited by 4 publications

(1 citation statement)

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“…We performed a literature review of cases of Bcc infections in non‐CF and nonoutbreak settings by searching the MEDLINE database since 1996 using the terms “ Burkholderia ” and “non‐cystic fibrosis.” A total of 17 cases were identified (Table ); most were case reports and 1 was a prospective observational study . Species identification was available for only 3 patients: 2 involved B. cenocepacia and 1 involved B. multivorans . Four cases (patients 2, 3, 8, and 12 in Table ) fit the clinical presentation of “cepacia syndrome” as characterized by rapid respiratory decline with bacteremia and necrotizing pneumonia.…”

Section: Discussionmentioning

confidence: 99%

Burkholderia multivorans septicemia in a pediatric liver transplant patient

Nashid

Waters

et al. 2019

American Journal of Transplantation

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"Cepacia syndrome", caused by Burkholderia cepacia complex and often associated with cystic fibrosis, carries a high mortality rate. It is rare for Burkholderia multivorans, a species within the B. cepacia complex, to cause cepacia syndrome even among patients with cystic fibrosis. This is the first reported fatal case of cepacia syndrome caused by B. multivorans occurring in a pediatric liver transplant recipient who does not have cystic fibrosis. We describe the unique characteristics of this pathogen among the non-cystic fibrosis population and the importance of early recognition and treatment.

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Section: Discussionmentioning

confidence: 99%

Burkholderia multivorans septicemia in a pediatric liver transplant patient

Nashid

Waters

et al. 2019

American Journal of Transplantation

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Identification of the Flagellin Glycosylation System in Burkholderia cenocepacia and the Contribution of Glycosylated Flagellin to Evasion of Human Innate Immune Responses

Hanuszkiewicz

Pittock

Humphries

et al. 2014

Journal of Biological Chemistry

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Background:The role of flagellin glycosylation is not well understood. Results:The Burkholderia cenocepacia flagellin is glycosylated on at least 10 different sites. Conclusion:The presence of glycan in flagellin significantly impaired the inflammatory response of epithelial cells. Significance: Flagellin glycosylation reduces recognition of flagellin by host TLR5, providing an evasive strategy to infecting bacteria.

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Calcium Binding-Mediated Sustained Release of Minocycline from Hydrophilic Multilayer Coatings Targeting Infection and Inflammation

et al. 2014

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Infection and inflammation are common complications that seriously affect the functionality and longevity of implanted medical implants. Systemic administration of antibiotics and anti-inflammatory drugs often cannot achieve sufficient local concentration to be effective, and elicits serious side effects. Local delivery of therapeutics from drug-eluting coatings presents a promising solution. However, hydrophobic and thick coatings are commonly used to ensure sufficient drug loading and sustained release, which may limit tissue integration and tissue device communications. A calcium-mediated drug delivery mechanism was developed and characterized in this study. This novel mechanism allows controlled, sustained release of minocycline, an effective antibiotic and anti-inflammatory drug, from nanoscale thin hydrophilic polyelectrolyte multilayers for over 35 days at physiologically relevant concentrations. pH-responsive minocycline release was observed as the chelation between minocycline and Ca2+ is less stable at acidic pH, enabling ‘smart’ drug delivery in response to infection and/or inflammation-induced tissue acidosis. The release kinetics of minocycline can be controlled by varying initial loading, Ca2+ concentration, and Ca2+ incorporation into different layers, enabling facile development of implant coatings with versatile release kinetics. This drug delivery platform can potentially be used for releasing any drug that has high Ca2+ binding affinity, enabling its use in a variety of biomedical applications.

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Isolation of Burkholderia cenocepacia J 2315 from non-cystic fibrosis pediatric patients in India

Cited by 4 publications

References 10 publications

Burkholderia multivorans septicemia in a pediatric liver transplant patient

Burkholderia multivorans septicemia in a pediatric liver transplant patient

Identification of the Flagellin Glycosylation System in Burkholderia cenocepacia and the Contribution of Glycosylated Flagellin to Evasion of Human Innate Immune Responses

Calcium Binding-Mediated Sustained Release of Minocycline from Hydrophilic Multilayer Coatings Targeting Infection and Inflammation

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