Isolation of Borna Disease Virus from Human Brain Tissue

Nakamura, Y.; Takahashi, Hirokazu; Shoya, Yuko; Nakaya, Takaaki; Watanabe, Makiko; Tomonaga, Keizō; Iwahashi, Kazuhiko; Ameno, Kiyoshi; Momiyama, Noriko; Taniyama, H.; Sata, Tetsutaro; Kurata, Takeshi; Torre, Juan Carlos de la; Ikuta, Kazuyoshi

doi:10.1128/.74.10.4601-4611.2000

Cited by 13 publications

(18 citation statements)

References 29 publications

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“…Sauder and de la Torre (23) reported that the levels of BDV in blood do not necessarily reflect viral load in the brain. It is also possible that the patients might have experienced a previous infection with BDV which was cleared by the immune system but which still resulted in CNS damage, since viral antigen could be detected in human autopsy brain tissue (27,28)). The third possibility is that our results may be false negative due to the inappropriate timing of blood sampling during the brief transient viremic phase of BDV.…”

Section: Discussionmentioning

confidence: 99%

Borna disease virus and deficit schizophrenia

Kim¹,

Kim

Han³

et al. 2003

Acta Neuropsychiatr.

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Section: Discussionmentioning

confidence: 99%

Borna disease virus and deficit schizophrenia

Kim¹,

Kim

Han³

et al. 2003

Acta Neuropsychiatr.

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“…Infection with SARS-CoV. In addition to Vero E6, the following cell lines were examined for infection by SARS-CoV: human oligodendroglioma-derived cell line OL [22] which was generated at the Wistar Institute, Philadelphia, USA [23]; rat glioma-derived cell line C6 [24]; human intestine-derived cell line CaCo-2; canine kidney-derived cell line MDCK; rabbit kidney-derived cell line RK13. All these cells were similarly infected with SARS-CoV at a multiplicity of infection (MOI) of 10.…”

Section: Methodsmentioning

confidence: 99%

Susceptibility of human and rat neural cell lines to infection by SARS-coronavirus

Yamashita

Yamate

et al. 2005

Biochemical and Biophysical Research Communications

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Pathological characterization of autopsied tissues from patients with SARS revealed severe damage in restricted tissues, such as lung, with no apparent cell damage in other tissues, such as intestine and brain. Here, we examined the susceptibility of neural cell lines of human (OL) and rat (C6) origins to SARS-associated coronavirus. Both of the neural cell lines showed no apparent cytopathic effects (CPE) by infection but produced virus with infectivity of 10(2-5) per ml, in sharp contrast to the production by infected Vero E6 cells of >10(9) per ml that showed a lytic infection with characteristic rounding CPE. Interestingly, the infection of intestinal cell line CaCo-2 also induced no apparent CPE, with production of the virus at a slightly lower level as that of the Vero E6 cell culture. Notably, the cellular receptor for the virus, angiotensin-converting enzyme 2 was expressed at similar levels on Vero E6 and CaCo-2 cells, but at undetectable levels on OL and C6 cells.

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“…It is based mainly on the fact that human sera frequently contain low levels of antibodies that can recognize BDV antigens and that such antibodies are found more frequently in patients with neurological disorders than in healthy individuals (1,5,67). The detection of viral nucleic acids or even infectious virus in patient specimens has been reported by many groups (7,53). However, it is likely that most if not all of these studies were flawed by contamination of patient samples with either laboratory viruses or PCR amplification products (15).…”

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confidence: 99%

Avian Bornavirus Associated with Fatal Disease in Psittacine Birds

Staeheli

Rinder

Kaspers

2010

J Virol

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Thanks to new technologies which enable rapid and unbiased screening for viral nucleic acids in clinical specimens, an impressive number of previously unknown viruses have recently been discovered. Two research groups independently identified a novel negative-strand RNA virus, now designated avian bornavirus (ABV), in parrots with proventricular dilatation disease (PDD), a severe lymphoplasmacytic ganglioneuritis of the gastrointestinal tract of psittacine birds that is frequently accompanied by encephalomyelitis. Since its discovery, ABV has been detected worldwide in many captive parrots and in one canary with PDD. ABV induced a PDD-like disease in experimentally infected cockatiels, strongly suggesting that ABV is highly pathogenic in psittacine birds. Until the discovery of ABV, the Bornaviridae family consisted of a single species, classical Borna disease virus (BDV), which is the causative agent of a progressive neurological disorder that affects primarily horses, sheep, and some other farm animals in central Europe. Although ABV and BDV share many biological features, there exist several interesting differences, which are discussed in this review.

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Isolation of Borna Disease Virus from Human Brain Tissue

Cited by 13 publications

References 29 publications

Borna disease virus and deficit schizophrenia

Borna disease virus and deficit schizophrenia

Susceptibility of human and rat neural cell lines to infection by SARS-coronavirus

Avian Bornavirus Associated with Fatal Disease in Psittacine Birds

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