Isolation of Bioactive Compounds from <i>Aspergillus terreus</i> LS07

Abstract

This study aims to search for the active compounds from Aspergillus terreus LS07 which isolated from an

γ-Butyrolactones from Aspergillus Species: Structures, Biosynthesis, and Biological Activities

“…In contrast, they had no 798 Natural Product Communications Vol. 12 (5) 2017 Ibrahim et al Antioxidant activities: Compounds 1, 2, and 16 showed significant activities against 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radicals with IC 50 values of 51.39, 17.64, and 47.55 μM, respectively using quercetin as a positive control (IC 50 39.63 μM) [9,59]. Compounds 57 and 58 exhibited moderate antioxidant activity in the DPPH assay with IC 50 values of 114.9, and 167.8 µM, respectively [41].…”

“…Compound 1 exhibited moderate inhibitory activity with an IC 50 value of 96.7 µM (glucosaccharo-(1,4)-lactone, positive control, IC 50 48.4 µM). Compounds 1 and 2 showed significant inhibitory activities towards α-glucosidase with IC 50 values of 52.2 and 96.0 μM, respectively using quercetin as a positive control (IC 50 14.6 μM) [9]. Furthermore, compounds 1, 57, and 58 exhibited strong -glucosidase inhibitory activities with IC 50 values of 52.2, 2.7, and 8.9 µM, respectively compared with quercetin (positive control, IC 50 10.9 µM) [41].…”

“…[40] A. terreus LS07 isolated from sea shore in Teluk Kodek, Pamenang area, West Nusa, Tenggara Province, Indonesia. [ 9 ] Aspergillus sp. isolated from the sponge Cliona chilensis collected in the Pacific Ocean, Los Molles (IV Región, Chile).…”

“…Many compounds isolated from Aspergillus possess pharmacological and commercial value. Lovastatin (mevinolin), isolated from A. terreus, is one of the antihyperlipidemic drugs that inhibit cholesterol biosynthesis and was a major drug agent in the treatment of heart disease and atherosclerosis [8][9]. Aspergillus is well known for the production of -butyrolactones, which are a class of amino acid derivative [1].…”

Analisis Nilai-Nilai Psikologis Pada Kesenian Wayang Ajen Bekasi

“…kebudayaan, pelbagai corak ragam kesenian yang ada di Indonesia ini terjadi karena adanya lapisan-lapisan kebudayaan yang bertumpuk dari masa ke masa (Dewi, Yuliasma, & Syarif, 2016). Di samping itu, keanekaragaman corak kesenian di sini juga terjadi karena adanya berbagai lingkungan budaya yang hidup berdampingan hingga saat ini.…”