Isolation of Avian Influenza Virus (H10N7) from an Emu (Dromaius novaehollandiae) with Conjunctivitis and Respiratory Disease

Woolcock, P. R.; Shivaprasad, H. L.; Rosa, M. De

doi:10.2307/1593122

Cited by 23 publications

(7 citation statements)

References 15 publications

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“…Recently, an H10N7 virus was isolated from dead harbor seals in Denmark 12 . A novel reassortant H10N7 AIV was found in chickens in Eastern China 11 12 13 14 15 16 17 18 19 20 21 22 23 . Additionally, an H10N4 isolate caused an outbreak of respiratory disease in mink in Sweden 15 .…”

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confidence: 99%

Characterization of the Pathogenesis of H10N3, H10N7, and H10N8 Subtype Avian Influenza Viruses Circulating in Ducks

Zhang

et al. 2016

Sci Rep

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Three H10 subtype avian influenza viruses were isolated from domestic ducks in China, designated as SH602/H10N8, FJ1761/H10N3 and SX3180/H10N7, with an intravenous pathogenicity index (IVPI) of 0.39, 1.60, and 1.27, respectively. These H10 viruses showed a complex pathology pattern in different species, although full genome characterizations of the viruses could not identify any molecular determinant underlying the observed phenotypes. Our findings describe the pathobiology of the three H10 subtype AIVs in chickens, ducks, and mice. FJ1761/H10N3 evolved E627K and Q591K substitutions in the gene encoding the PB2 protein in infected mice with severe lung damage, suggesting that H10 subtype avian influenza viruses are a potential threat to mammals.

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Characterization of the Pathogenesis of H10N3, H10N7, and H10N8 Subtype Avian Influenza Viruses Circulating in Ducks

Zhang

et al. 2016

Sci Rep

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“…While macroscopic ocular signs are generally not common following influenza virus inoculation by the intranasal route in laboratory species, conjunctivitis has been reported following experimental inoculation of dogs and mice with H5N1 virus and of ferrets with H7N3 virus (72,125). Concurrent ocular and respiratory disease has been documented for a diverse range of species infected with influenza virus subtypes not associated with human disease (126)(127)(128), underscoring a need to monitor the incidence of ocular symptoms during viral surveillance. While future studies are needed to identify the particular molecular determinants that confer the ocular tropism observed for viruses within the H7 subtype, these reports demonstrate that the eye and surrounding conjunctiva represent a permissive port of entry for all influenza virus subtypes.…”

Section: Orthomyxovirusesmentioning

confidence: 99%

Ocular Tropism of Respiratory Viruses

Belser

Rota

Tumpey

2013

Microbiol Mol Biol Rev

307

353

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SUMMARY Respiratory viruses (including adenovirus, influenza virus, respiratory syncytial virus, coronavirus, and rhinovirus) cause a broad spectrum of disease in humans, ranging from mild influenza-like symptoms to acute respiratory failure. While species D adenoviruses and subtype H7 influenza viruses are known to possess an ocular tropism, documented human ocular disease has been reported following infection with all principal respiratory viruses. In this review, we describe the anatomical proximity and cellular receptor distribution between ocular and respiratory tissues. All major respiratory viruses and their association with human ocular disease are discussed. Research utilizing in vitro and in vivo models to study the ability of respiratory viruses to use the eye as a portal of entry as well as a primary site of virus replication is highlighted. Identification of shared receptor-binding preferences, host responses, and laboratory modeling protocols among these viruses provides a needed bridge between clinical and laboratory studies of virus tropism.

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“…Reported outbreaks of low pathogenicity avian influenza (LPAI) viruses of influenza A subtype H10 in poultry are uncommon but have occurred among turkeys and emus in the United States ( 1 , 2 ), farmed Pekin ducks in South Africa ( 3 ), and chickens in Canada ( 4 ). Isolation of influenza virus A (H10N7) was reported in Italy from smuggled poultry products from China ( 5 ).…”

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confidence: 99%