Isolation of Apoptosis- and Differentiation-Inducing Substances toward Human Promyelocytic Leukemia HL-60 Cells from Leaves of<i>Juniperus taxifolia</i>

Muto, Norio; Tomokuni, T; Haramoto, Mari; Tatemoto, Hideki; Nakanishi, Teruyuki; Inatomi, Yuka; Murata, Hiroko; Inada, Akira

doi:10.1271/bbb.70570

Cited by 63 publications

(38 citation statements)

References 28 publications

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“…The literature survey shows that the content of dO-PDP has never exceeded 0.6% DW (Cairnes et al, 1980;Hartwell et al, 1953;Kusari et al, 2011;Muto et al, 2008). In our study: J. davurica, J. sabina L. ''Variegata'', and J. sabina var.…”

Section: Analysis Of Podophyllotoxin and Deoxypodophyllotoxin Contentmentioning

confidence: 41%

“…Both lignans demonstrated a wide range of DOI: 10.3109/13880209.2014.943246 relevant properties against a number of cancer cell lines (Ikeda et al, 1998;Kim et al, 2002;Masuda et al, 2002;Muto et al, 2008;Renouard et al, 2011;Xu et al, 2010).…”

Section: Analysis Of Cell Viabilitymentioning

confidence: 99%

“…Some of the lignans, in particular podophyllotoxin (PDP), are known to have anticancer, antifungal, and antimicrobial properties (Gordaliza et al, 2004). Deoxypodophyllotoxin (dO-PDP), in turn, has demonstrated a wide range of relevant properties against a number of cancer cell lines (Ikeda et al, 1998;Kim et al, 2002;Masuda et al, 2002;Muto et al, 2008;Renouard et al, 2011;Xu et al, 2010). PDP was first extracted from Podophyllum peltatum L. (Berberidaceae) and from Linum sp.…”

Section: Introductionmentioning

confidence: 99%

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Study of cytotoxic activity, podophyllotoxin, and deoxypodophyllotoxin content in selectedJuniperusspecies cultivated in Poland

Och

Cieśla³

et al. 2015

Pharmaceutical Biology

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Context: The demand for podophyllotoxin and deoxypodophyllotoxin is still increasing and commercially exploitable sources are few and one of them, Podophyllum hexandrum Royle (Berberidaceae), is a ''critically endangered'' species. Objective: The first aim was to quantify the amount of podophyllotoxin and deoxypodophyllotoxin in 61 Juniperus (Cupressaceae) samples. Cytotoxic activity of podophyllotoxin and ethanolic leaf extracts of Juniperus scopulorum Sarg. ''Blue Pacific'' and Juniperus communis L. ''Depressa Aurea'' was examined against different leukemia cell lines. Materials and methods: Ultra-performance liquid chromatography (UPLC) analysis was performed with the use of a Waters ACQUITY UPLC TM system (Waters Corp., Milford, MA). The peaks of podophyllotoxin and deoxypodophyllotoxin were assigned on the basis of their retention data and mass-to-charge ratio (m/z). Trypan blue assay was performed to obtain IC 50 cytotoxicity values against selected leukemia cell lines. Results: Juniperus scopulorum was characterized with the highest level of podophyllotoxin (486.7 mg/100 g DW) while Juniperus davurica Pall. contained the highest amount of deoxypodophyllotoxin (726.8 mg/100 g DW). Podophyllotoxin IC 50 cytotoxicity values against J45.01 and CEM/C1 leukemia cell lines were 0.0040 and 0.0286 mg/mL, respectively. Juniperus scopulorum extract examined against J45.01 and HL-60/MX2 leukemia cell lines gave the respective IC 50 values: 0.369-9.225 mg/mL. Juniperus communis extract was characterized with the following IC 50 cytotoxity values against J45.01 and U-266B1 cell lines: 3.310-24.825 mg/mL. Conclusions: Juniperus sp. can be considered as an alternative source of podophyllotoxin and deoxypodophyllotoxin. Cytotoxic activity of podophyllotoxin and selected leaf extracts of Juniperus sp. against a set of leukemia cell lines was demonstrated.

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Section: Analysis Of Podophyllotoxin and Deoxypodophyllotoxin Contentmentioning

confidence: 41%

Section: Analysis Of Cell Viabilitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Study of cytotoxic activity, podophyllotoxin, and deoxypodophyllotoxin content in selectedJuniperusspecies cultivated in Poland

Och

Cieśla³

et al. 2015

Pharmaceutical Biology

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“…Various pharmacological effects of several Juniperus species have been reported so far including antitumoral, antifertility, abortifacient, diuretic, vasorelaxing (Seca and Silva, 2007), antiinflammatory (El-Sayed, 1998;Seca and Silva, 2007), antimicrobial (Seca and Silva, 2007;Unlu et al, 2008), antioxidant (Elmastaş et al, 2006;Emami et al, 2007;Kırca and Arslan, 2008), cytotoxic (Topç u et al, 2005;Seca and Silva, 2007;Muto et al, 2008;Moujir et al, 2008), anti-obesity (Kim et al, 2008), anthelmintic (Kozan et al, 2006) and immunomodulatory (Schepetkin et al, 2005).…”

Section: Resultsmentioning

confidence: 99%

A comparative study on the antinociceptive and anti-inflammatory activities of five Juniperus taxa

Akkol

Güvenç

Yeşilada

2009

Journal of Ethnopharmacology

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“…This historically old genera is important for providing information about evolution of plants in Late Glacial period (Koller et al, 2005;Li et al, 2011, Veski et al, 2012. Juniperus contains economically valuable species used for medicinal purposes (Muto et al, 2008;Kusari et al, 2009), perfume industry (Lawrence, 1984, flavoring of food and alcoholic beverages (Maarse, 1991;Vichi et al, 2007). These circumstances point out the need of comprehensive knowledge about Juniperus species.…”

mentioning

confidence: 99%

Variety of habitats associated with common juniper (Juniperus communis L.) growing in Lithuania

Vilčinskas¹,

Marozas²,

Jocienė³

et al. 2016

biologija

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Common juniper (Juniperus communis L.) is an important conifer from the ecological and economical point of view. In some areas of the distribution range, it is a widely studied species. Up till now insufficient attention has been paid to junipers growing in the Baltic countries where it is one of three natural conifers and important forest tree species. Recently, molecular markers-based diversity of Lithuanian populations of J. communis was determined, although related biological and ecological variables remain undisclosed. The present study is aimed at the evaluation of biotic and abiotic environment of J. communis according to plant species composition. Fourteen sites with J. communis were selected in the territory of Lithuania. At each site undergrowth trees and shrubs, herbaceous species, dwarf shrubs, and mosses were recorded and the abundance of each species was evaluated. Abiotic environment characteristics were obtained using Ellenberg's indicator values (EIV) of the plant species neighbouring junipers. In the sites with J. communis, 80 species of herbs and dwarf shrubs belonging to 18 families were registered. The largest variety of herbaceous species and dwarf shrubs (18-22 per site) was registered for sites representing xero-thermophile fringes. Species coverage data recorded in the sites in most cases allowed to group sites according to their habitats. Despite rather small territory of the present survey (latitude (N) 56°07'-54°11' , longitude (E) 21°06'-26°30'), the ranges of indexes for environment factors of juniper sites were rather wide: 6.0-7.3 for light, 3.0-5.8 for temperature, 3.7-5.3 for continentality, 4.2-7.8 for soil moisture, 2.7-7.4 for soil reaction, and 2.7-4.4 for soil nitrogen. Among the sites selected by us, the most contrasting in terms of EIV were locations representing coastal brown dunes covered with natural Scots pine forests and xero-thermophile fringes. Keywords INTRODUCTIONJuniperus species are substantial elements of present-day forests (Garcia et al., 2000;Adams, 2011) and some of them are on the border of extinction (Lima et al., 2010;Rumeu et al., 2011;Silva et al., 2011). This historically old genera is important for providing information about evolution of plants in Late Glacial period (Koller et al., 2005;Li et al., 2011, Veski et al., 2012. Juniperus contains economically valuable species used for medicinal purposes (Muto et al., 2008;Kusari et al., 2009), perfume industry (Lawrence, 1984, flavoring of food and alcoholic beverages (Maarse, 1991;Vichi et al., 2007). These circumstances point out the need of comprehensive knowledge about Juniperus species.Juniperus communis is widely distributed over the Northern hemisphere, growing in Europe and three other continents. Junipers have been examined by molecular and biochemical markers in various regions of their natural occurrence (Canary Islands, Greece, Germany, UK, Russia, Japan, China, Kazakhstan, Nepal, Ethiopia, Guatemala, Cuba, Mexico, Utah, Texas, etc. (Adams et al., 2003;Adams, 2011). Examination of variabl...

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Isolation of Apoptosis- and Differentiation-Inducing Substances toward Human Promyelocytic Leukemia HL-60 Cells from Leaves ofJuniperus taxifolia

Cited by 63 publications

References 28 publications

Study of cytotoxic activity, podophyllotoxin, and deoxypodophyllotoxin content in selectedJuniperusspecies cultivated in Poland

Study of cytotoxic activity, podophyllotoxin, and deoxypodophyllotoxin content in selectedJuniperusspecies cultivated in Poland

A comparative study on the antinociceptive and anti-inflammatory activities of five Juniperus taxa

Variety of habitats associated with common juniper (Juniperus communis L.) growing in Lithuania

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