Isolation of a viral agent causing hematopoietic neoplasia in the soft-shell clam, Mya arenaria

Oprandy, John J.; Chang, P. W.; Pronovost, A. D.; Cooper, Keith; Brown, Robert; Yates, Vance J.

doi:10.1016/0022-2011(81)90033-1

Cited by 103 publications

(70 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Whether the disease in these experiments was transmitted via cell transplantation or an infective agent was unclear. In another bivalve, the soft clam, evidence of retroviral origin was reported in three separate studies (Oprandy et al 1981, 1983, Medina et al 1993, House et al 1998. Interestingly, attempts to transmit mussel neoplasia to other bivalve species such as soft clams (Mya arenaria), flat oysters (Ostrea edulis) and Olympia oysters (Ostrea conchphila), failed.…”

Section: Introductionmentioning

confidence: 98%

Disseminated neoplasia in blue mussels, Mytilus galloprovincialis, from the Black Sea, Romania

Ciocan

Sunila

2005

Marine Pollution Bulletin

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 98%

Disseminated neoplasia in blue mussels, Mytilus galloprovincialis, from the Black Sea, Romania

Ciocan

Sunila

2005

Marine Pollution Bulletin

View full text Add to dashboard Cite

“…Stressors such as pollution (1,11), temperature (12), and overcrowding have been implicated in disease development. There is evidence that the disease can be transmitted from infected to uninfected individuals (13,14), indicative of an infectious etiology. Unfiltered hemolymph, lysed hemocytes (15), and even filtered hemolymph isolated from BrdU-treated animals (16) were found to induce disease in healthy animals, raising the possibility of a filterable transmissible agent such as a virus.…”

mentioning

confidence: 99%

“…Induction of disease by the retroviral inducer BrdU (17) suggested the possible involvement of an endogenous retrovirus or retrotransposon. Some studies have detected reverse transcriptase (RT) activity in neoplastic clam tissues (14,(18)(19)(20)(21), suggesting that a retroelement or retrovirus might be involved in the disease process, but to date searches for viruses and retroviral sequences from leukemic clams have not been successful (22).…”

mentioning

confidence: 99%

Activation of transcription and retrotransposition of a novel retroelement, Steamer , in neoplastic hemocytes of the mollusk Mya arenaria

Arriagada

Metzger

Muttray

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Significance The soft shell clam in many areas of the North Atlantic is afflicted with a fatal leukemia-like disease of unknown origin. Leukemic cells from the diseased animals were found to release reverse transcriptase and to express high RNA levels of a previously unknown member of the gypsy family of retroelements, Steamer . The DNA copy number of the element was increased to enormously high levels in diseased cells, mediated by reverse transcription and integration into the host genome. The activation of Steamer expression and transposition may initiate or accelerate the course of leukemia and constitutes a potential diagnostic marker of the disease.

show abstract

“…The disease is characterized by proliferation of enlarged circulating hemocytes with a large lobate nucleus, one or more nucleoli, a high frequency of mitotic figures, and a high nucleus to cytoplasm ratio (Farley, 1969;Mix, 1983). The etiology of molluscan neoplasia remains uncertain, and several researchers have suggested possible causes ranging from carcinogenic chemicals (Lowe and Moore, 1978;Farley et al, 1991), to involvement of a c-type retrovirus (Oprandy et al, 1981;Elston et al, 1988), to genetic disposition of individuals (Couch and Harshbarger, 1985).…”

Section: Introductionmentioning

confidence: 99%

Environmental Contaminants and the Prevalence of Hemic Neoplasia (Leukemia) in the Common Mussel (Mytilus edulisComplex) from Puget Sound, Washington, U.S.A.

Krishnakumar

Casillas

Snider

et al. 1999

Journal of Invertebrate Pathology

View full text Add to dashboard Cite

The relationship between hemic neoplasia, a blood cell disorder in bivalve molluscs, and chemical contaminants was evaluated in the common mussel (Mytilus edulis complex). Hemic neoplasia (HN) is endemic to mussel populations in Puget Sound. The prevalence of hemic neoplasia ranged from 0 to 30% in mussels from nine sites in Puget Sound, Washington. Organic chemical contamination in sediment from these sites range from 0.1 to 64.0 ppm of polycyclic aromatic hydrocarbons (PAHs) and 0.07 to 0.50 ppm chlorinated hydrocarbons. No relationship between the body burden of environmental contaminants and the prevalence of HN in mussels was identified. To evaluate the shortterm ability of chemical contaminants to induce HN in mussels, mussels, from a site where mussels were previously determined to be HN free, were fed microencapsulated PAHs (composed of a mixture of phenanthrene, flouranthene, and benzo[a]pyrene) or PCBs (Aroclor 1254) and the prevalence of HN was assessed after 30 days of exposure. Although an apparent increase in HN prevalence (20 to 30%) was observed in all treatments groups except the untreated controls, no significant difference in the prevalence of HN was observed between the control group of mussels fed corn oil (vehicle) and mussels fed either PAHs or PCBs in corn oil. A long-term (180-day) exposure study was conducted to evaluate the influence of PAHs or PCBs in modulating the prevalence of HN in a mussel population already exhibiting a moderate HN prevalence. Mussels, from a site where mussels were previously determined to exhibit a background prevalence of HN, fed microencapsulated PAHs, PCBs, and corn oil (vehicle) over a long time period (180 days), revealed an apparent increased prevalence of HN (30 to 40%) above the low levels (20%) initially present. However, no significant difference in the prevalence of HN was observed between the control group of mussels fed corn oil (vehicle) and mussels fed either PAHs or PCBs in corn oil. Although chemical contaminants have been proposed as a modulating factor in the development and promotion of HN in bivalve molluscs from environmentally stressed and degraded habitats, we find no evidence that chemical contaminants induce or promote the development of HN in the mussel M. edulis complex. Academic Press

show abstract

Isolation of a viral agent causing hematopoietic neoplasia in the soft-shell clam, Mya arenaria

Cited by 103 publications

References 10 publications

Disseminated neoplasia in blue mussels, Mytilus galloprovincialis, from the Black Sea, Romania

Disseminated neoplasia in blue mussels, Mytilus galloprovincialis, from the Black Sea, Romania

Activation of transcription and retrotransposition of a novel retroelement, Steamer , in neoplastic hemocytes of the mollusk Mya arenaria

Environmental Contaminants and the Prevalence of Hemic Neoplasia (Leukemia) in the Common Mussel (Mytilus edulisComplex) from Puget Sound, Washington, U.S.A.

Contact Info

Product

Resources

About