Isolation of a unique retrovirus, MNV-1, from Macaca nemestrina

Hefti, Elisabeth; Ip, John; Giddens, W. E.; Panem, Sandra

doi:10.1016/0042-6822(83)90146-0

Cited by 11 publications

(2 citation statements)

References 17 publications

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“…Our review of the histopathology of one such monkey dying in 1972 showed lymphoid depletion typical of SAIDS. A mixture of type C and type D retroviruses was also recently isolated from a pigtailed macaque (Macaca nemestrina) with enzootic retroperitoneal fibrosis at the University of Washington Primate Center (13). This isolate was lost during cultivation in vitro and is not available for comparison with the SAIDS retrovirus (13).…”

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Simian AIDS: Isolation of a Type D Retrovirus and Transmission of the Disease

Marx

Maul

Osborn

et al. 1984

Science

217

109

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mentioning

confidence: 99%

Simian AIDS: Isolation of a Type D Retrovirus and Transmission of the Disease

Marx

Maul

Osborn

et al. 1984

Science

217

109

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“…The D2/RHE/OR and closely related SRV-2 strains (SRV-2B) have also been identified in endemic infections of pig-tail monkeys (M. nemestrina), cynomolgus monkeys (M. fascicularis) and rhesus monkeys (M. mulatta) in the Washington and Oregon National Primate Research Center (Bryant et al, 1986;Grant et al, 1995;Hefti et al, 1983;Marracci et al, 1995 Marracci et al, , 1999 PhilippStaheli et al, 2006;Stromberg et al, 1984). In the present study, we isolated a novel SRV-5-like virus by culture from a Japanese monkey.…”

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Isolation and DNA characterization of a simian retrovirus 5 from a Japanese monkey (Macaca fuscata)

Takano

León

Kato

et al. 2013

Journal of General Virology

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An SRV-like virus was isolated from a colony-born Japanese monkey. To identify this SRV-like virus, we designed universal primers at regions that were conserved among the reported SRV sequences in the 59-LTR and the short ORF and we obtained plasmid clones containing the complete gag, prt, pol and env genes. The full-length sequences of the isolate were determined from the plasmids and by direct sequencing. Sequence comparisons and phylogenetic analyses indicated that this SRV-like virus had a sequence identical to the reported 626 bp of SRV-5. In this study, we isolated SRV5/JPN/2005/V1 from a Japanese monkey and characterized the fulllength SRV-5 sequence.Simian betaretroviruses (SRVs) (formerly known as simian type D retroviruses; SRV/Ds) have been isolated from Asian monkeys of the genus Macaca. SRVs are among the most important infectious agents in macaque colonies because SRVs cause immunodeficiency, anaemia, weight loss, tumours and persistent refractory diarrhoea (Daniel et al., 1984;Giddens et al., 1985;Lerche et al., 1987;Marx et al., 1984). Five distinct types of SRVs, SRV-1 through SRV-5, have been identified, based on neutralization tests. Furthermore, the complete DNA sequences of SRV-1, -2, -3 and -4, and the partial sequence of SRV-5 have been reported (Li et al., 2000; Power et al., 1986;Sonigo et al., 1986;Thayer et al., 1987;Zao et al., 2010). The serotype classifications for SRV-1 to SRV-5 have also been well supported by these phylogenetic analyses. Additionally, SRV-T, SRV-6 and SRV-7, have been identified, based on the results of phylogenetic analyses (Hara et al., 2005;Nandi et al., 2000Nandi et al., , 2006. SRV-T was reported as a virus strain of SRV-4 based on sequencing analysis (White et al., 2009;Zao et al., 2010).Only one SRV virus strain, D2/RHE/OR, has been isolated from a Japanese monkey (Macaca fuscata) at the Washington National Primate Research Center (Giddens et al., 1985). The D2/RHE/OR and closely related SRV-2 strains (SRV-2B) have also been identified in endemic infections of pig-tail monkeys (M. nemestrina), cynomolgus monkeys (M. fascicularis) and rhesus monkeys (M. mulatta) in the Washington and Oregon National Primate Research Center (Bryant et al., 1986;Grant et al., 1995;Hefti et al., 1983;Marracci et al., 1995 Marracci et al., , 1999 PhilippStaheli et al., 2006;Stromberg et al., 1984). In the present study, we isolated a novel SRV-5-like virus by culture from a Japanese monkey. We sequenced the complete proviral genome of this isolate and compared it with other known SRVs.Colony-born Japanese monkeys, J-03-001F1, J-04-067F1, J-07-005F1 and J-07-016F1, were bred and reared at a private monkey facility in Japan. As these animals showed persistent diarrhoea, anaemia and weight loss, the serum and EDTA-treated whole blood samples were sent to our laboratory for diagnosis. No PCR products were amplified from these samples using published primer sets that amplify SRV-1, -2, -3 or -4 (SRV-T) (Fujimoto et al., 2010;Liska et al., 1997) (data not shown). Virus isolation wa...

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Simian AIDS—Evidence for a retroviral etiology

Gardner

Marx

Maul

et al. 1984

Hematological Oncology

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This paper reviews the major features of a simian model of acquired immunodeficiency ('SAIDS'), SAIDS occurs endemically in colonies of macaque monkeys in the United States and resembles AIDS in humans in overall clinical manifestations, pathology, and immune deficiency. An infectious type D retrovirus, related to but distinct from the Mason-Pfizer monkey virus, has been identified as the primary cause of SAIDS. The relevance of these findings for human AIDS is discussed.

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Isolation of a unique retrovirus, MNV-1, from Macaca nemestrina

Cited by 11 publications

References 17 publications

Simian AIDS: Isolation of a Type D Retrovirus and Transmission of the Disease

Simian AIDS: Isolation of a Type D Retrovirus and Transmission of the Disease

Isolation and DNA characterization of a simian retrovirus 5 from a Japanese monkey (Macaca fuscata)

Simian AIDS—Evidence for a retroviral etiology

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