Isolation of a new cytotoxic compound, 3-((Z)-heptadec-14-enyl) benzene - 1-ol from Rhus natalensis root extract

Matata, Daniel Zacharia; Moshi, Mainen J.; Machumi, Francis; Ngassapa, Olipa; Swanepoel, Bresler; Oosthuizen, Kenneth; Venables, Luanne; Koekemoer, Trevor; Heydenreich, Matthias; Kazyoba, Paul; Venter, Maryna van de

doi:10.1016/j.phytol.2020.01.024

Cited by 6 publications

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“…No toxicity was reported up to a dose of 2500 mg/kg and LD 50 was reported to be > 5000 mg/kg [ 24 ] Rhus natalensis Bernh. Diarrhea, influenza [ 25 ] Respiratory disorders, Malaria [ 26 ] Antinociceptive activity (dichloromethane-methanol extract) [ 27 ], antibacterial activity (aqueous extract) [ 25 ] In vivo (Swiss albino mice) [ 27 ], in vitro (Standard plate count method) [ 25 ] 3-( Z )-heptadec-14-enyl) benzene-1-ol isolated from the ethyl acetate root extract of R. natalensis was reported to be toxic in brine shrimp larvae (LC 50 = 7.25 µg/mL), induced apoptosis, and caused cell cycle arrest [ 28 ] Steganotaenia araliacea Hochst. Skin diseases [ 29 ], tuberculosis [ 30 ] Antibacterial activity (aqueous and methanol root extracts) [ 31 ], uterotonic activity in uterine strips of pregnant rats [ 32 ], diuretic activity (aqueous, methanol, and ethanol stem bark extracts) [ 33 ] In vitro (Agar well diffusion method) [ 31 ], ex vivo ( Wistar rats; organ bath) [ 32 ], in vivo ( Wistar rats) [ 33 ] The 80% ethanolic stem bark extract was reported to be cytotoxic against MDA-MB-231 (breast), PANC-1 (pancreas), and HT-29 (colon) cancer cell lines [ 34 ] Dibenzocyclo-Octadiene, a lignan constituent was reported to have antimitotic activity [ 35 ].…”

Section: Resultsmentioning

confidence: 99%

Medicinal plants used in managing diseases of the respiratory system among the Luo community: an appraisal of Kisumu East Sub-County, Kenya

et al. 2020

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Background: Poor access to healthcare in rural communities causes many people to seek herbalists who use medicinal plants for the treatment of various disease conditions. Most knowledge of traditional herbal medicine makes use of indigenous remedies which are often undocumented and are at risk of being lost. The preservation of this knowledge may facilitate scientific inquiry into promising new therapeutic molecules. Methods: Semi-structured questionnaires were used to collect the sociodemographic information of 30 herbalists in Kisumu East Sub County. The local names of medicinal plants used in managing illnesses of the respiratory system, their habit, active parts, indications, methods of preparation, routes of administration, scientific identity, and conservation status were also recorded. Other reported traditional uses, pharmacological activities, and toxicological data were identified via a literature search. Results: Most herbalists were female (86.7%), aged between 61 and 70 years (43.3%) with no formal education (56.7%), and had 21-30 years of practice (30%). 44 plant species, belonging to 43 genera and 28 families were identified. Leguminosae and Rutaceae plant families were predominant, leaves were frequently used (33%), and trees were the most common habit (44.4%). Most plants were collected in the wild (79.2%), preparation was mainly by decoction (68.8%), and the administration was mainly orally. The main indication was cough and 79.5% of all documented plant species had previously been reported to have a pharmacological activity relevant to the mitigation of respiratory illnesses. Toxicological data was available for 84.1% of the plant species identified. Conclusions: The predominant use of roots, root barks, and root tubers by herbalists in Kisumu East Sub County threatens to negatively impact the ecological survival of some plant species. The preservation of herbalists' knowledge of medicinal plants in the study area is a pressing concern considering their advanced age and little formal education. There is a need to conserve some of the medicinal plants documented in this study. The medicinal claims made by herbalists also warrant scientific scrutiny.

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Section: Resultsmentioning

confidence: 99%

Medicinal plants used in managing diseases of the respiratory system among the Luo community: an appraisal of Kisumu East Sub-County, Kenya

et al. 2020

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“…DPPH titration curves were obtained using a modified method based on the assay by Brand-Williams et al, 1995 [16,17]. Briefly, 5 μl of a serial dilution of the extract was placed in the wells of a 96well plate followed by 120 μl Tris-HCl (50 mM, pH 7.4) and 120 μl of freshly prepared DPPH solution (0.1 mM in absolute ethanol).…”

Section: Antioxidant Activitymentioning

confidence: 99%

Diospyros lotus L. fruit: A potential antidiabetic functional food targeting intestinal starch hydrolysis

et al. 2021

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Post-meal hyperglycaemia is considered a prominent therapeutic target to attenuate the progression of diabetes and its associated complications. The present study identified fruit extract of Diospyros lotus Linnaeus, of the Ebenaceae family, as an inhibitor of starch digestion through the inhibition of both alpha amylase and alpha glucosidase. The extract inhibits porcine and human pancreatic amylase with IC50 values of 82.5±2.0 and 130.4±24 μg/ml respectively. The inhibition of intestinal sucrase and maltase activity was however considerably weaker. In vitro hydrolysis of solubilised potato starch into glucose yielded comparable inhibition kinetics for 100 μg/ml D. lotus L. extract and 3.5 μM acarbose. Screening the major phenolic constituents revealed that quercetin and myricetin were the strongest alpha amylase inhibitors. D. lotus L. extract showed strong antioxidant activity; however, this provided no meaningful protection against 2-deoxy-ribose induced oxidative stress in INS-1 cells. Taken together these findings identify D. lotus L. fruit as a multi-component functional food with potential to dampen the onset and development of diabetes through the inhibition of post meal hyperglycaemia.

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Role of Traditional Chewing Sticks in Oral Hygiene and Other Benefits

Beshah

Hunde

Getachew

et al. 2021

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Isolation of a new cytotoxic compound, 3-((Z)-heptadec-14-enyl) benzene - 1-ol from Rhus natalensis root extract

Cited by 6 publications

References 21 publications

Medicinal plants used in managing diseases of the respiratory system among the Luo community: an appraisal of Kisumu East Sub-County, Kenya

Medicinal plants used in managing diseases of the respiratory system among the Luo community: an appraisal of Kisumu East Sub-County, Kenya

Diospyros lotus L. fruit: A potential antidiabetic functional food targeting intestinal starch hydrolysis

Role of Traditional Chewing Sticks in Oral Hygiene and Other Benefits

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