Isolation of a Chlamydia From Cases of Keratoconjunctivitis in Koalas

Chlamydophila pecorum found in the intestine and vaginal mucus of asymptomatic ruminants has also been associated with different pathological conditions in ruminants, swine and koalas. Some endangered species such as water buffalos and bandicoots have also been found to be infected by C. pecorum. The persistence of C. pecorum strains in the intestine and vaginal mucus of ruminants could cause long-term sub-clinical infection affecting the animal’s health. C. pecorum strains present many genetic and antigenic variations, but coding tandem repeats have recently been found in some C. pecorum genes, allowing C. pecorum strains isolated from sick animals to be differentiated from those isolated from asymptomatic animals. This review provides an update on C. pecorum infections in different animal hosts and the implications for animal health. The taxonomy, typing and genetic aspects of C. pecorum are also reviewed.

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“…pecorum strains cause conjunctivitis, urinary and reproductive tract disease and infertility [9, 50]. The level of C .…”

Section: Pecorum Infectionsmentioning

confidence: 99%

Recent advances in the understanding ofChlamydophila pecoruminfections, sixteen years after it was named as the fourth species of the Chlamydiaceae family

Mohamad

Rodolakis

2009

Vet. Res.

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“…C. pecorum infection in koalas has been associated with cystitis, proliferative conjunctivitis and chronic, fibrotic disease of the urogenital tract leading to infertility and death [13], [14], [15], [9], [16], [12]. In non-koala hosts, the role of cell mediated immunity (CMI) as the major immune response generated by the host against chlamydial infection is acknowledged [17], [18], [19].…”

Section: Introductionmentioning

confidence: 99%

Preliminary Characterisation of Tumor Necrosis Factor Alpha and Interleukin-10 Responses to Chlamydia pecorum Infection in the Koala (Phascolarctos cinereus)

Mathew

Beagley

2013

PLoS ONE

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Debilitating infectious diseases caused by Chlamydia are major contributors to the decline of Australia's iconic native marsupial species, the koala (Phascolarctos cinereus). An understanding of koala chlamydial disease pathogenesis and the development of effective strategies to control infections continue to be hindered by an almost complete lack of species-specific immunological reagents. The cell-mediated immune response has been shown to play an influential role in the response to chlamydial infection in other hosts. The objective of this study, hence, was to provide preliminary data on the role of two key cytokines, pro-inflammatory tumour necrosis factor alpha (TNFα) and anti-inflammatory interleukin 10 (IL10), in the koala Chlamydia pecorum response. Utilising sequence homology between the cytokine sequences obtained from several recently sequenced marsupial genomes, this report describes the first mRNA sequences of any koala cytokine and the development of koala specific TNFα and IL10 real-time PCR assays to measure the expression of these genes from koala samples. In preliminary studies comparing wild koalas with overt chlamydial disease, previous evidence of C. pecorum infection or no signs of C. pecorum infection, we revealed strong but variable expression of TNFα and IL10 in wild koalas with current signs of chlamydiosis. The description of these assays and the preliminary data on the cell-mediated immune response of koalas to chlamydial infection paves the way for future studies characterising the koala immune response to a range of its pathogens while providing reagents to assist with measuring the efficacy of ongoing attempts to develop a koala chlamydial vaccine.

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“…By contrast, C. pneumoniae tends to be implicated in less severe disease and sole C. pneumoniae infections are often low‐grade or asymptomatic . Clinical disease induced by C. pecorum and C. pneumoniae in koalas consists of a spectrum of ocular, urogenital and respiratory disease. Although the latter has been incompletely described, ocular disease can result in severe keratoconjunctivitis and urogenital disease can lead to debilitating cystitis, infertility and ascending pyelonephritis …”

mentioning

confidence: 99%

In vitro activity of chloramphenicol, florfenicol and enrofloxacin againstChlamydia pecorumisolated from koalas (Phascolarctos cinereus)

2015

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Isolation of a Chlamydia From Cases of Keratoconjunctivitis in Koalas

Cited by 52 publications

References 3 publications

Recent advances in the understanding ofChlamydophila pecoruminfections, sixteen years after it was named as the fourth species of the Chlamydiaceae family

Recent advances in the understanding ofChlamydophila pecoruminfections, sixteen years after it was named as the fourth species of the Chlamydiaceae family

Preliminary Characterisation of Tumor Necrosis Factor Alpha and Interleukin-10 Responses to Chlamydia pecorum Infection in the Koala (Phascolarctos cinereus)

In vitro activity of chloramphenicol, florfenicol and enrofloxacin againstChlamydia pecorumisolated from koalas (Phascolarctos cinereus)

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