ISOLATION OF 5-METHOXYINDOLE-3-ACETIC ACID FROM BOVINE PINEAL GLANDS<sup>1</sup>

Lerner, Aaron B.; Case, James D.; Biemann, K.; Heinzelman, R. V.; Szmuszkovicz, Jacob; Anthony, W. C.; Krivis, Alan F.

doi:10.1021/ja01528a064

Cited by 133 publications

(113 citation statements)

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“…19 Melatonin is a hormone primarily synthesized by pinealocytes in the pineal gland. 26 Machida et al 27 found that pinealectomy in chickens consistently produces scoliosis, and intramuscular implantation of the pineal gland into pinealectomized chickens prevents the development of experimentally induced scoliosis. In a clinical study, the melatonin levels of patients with progressive scoliosis were significantly lower than those of controls.…”

mentioning

confidence: 99%

Lack of association between adolescent idiopathic scoliosis and previously reported single nucleotide polymorphisms in MATN1, MTNR1B, TPH1, and IGF1 in a Japanese population

Takahashi

Matsumoto

Karasugi

et al. 2011

Journal Orthopaedic Research

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Adolescent idiopathic scoliosis (AIS) is a spinal deformity most commonly arising in apparently healthy girls around puberty. AIS has a strong genetic predisposition. Several genetic associations between AIS and single nucleotide polymorphisms (SNPs) have been reported; common SNPs in the genes for matrilin 1 (MATN1), melatonin receptor 1B (MTNR1B), tryptophan hydroxylase 1 (TPH1), and insulin-like growth factor 1 (IGF1) are reported to be associated with AIS in Chinese. However, these associations have not been replicated so far. To confirm the associations, we compared these SNPs with AIS predisposition and curve severity in a population of Japanese females consisting of 798 AIS patients and 1,239 controls. All the subjects were genotyped using the PCR-based Invader assay. We found no association of any of the SNPs with AIS predisposition or curve severity. Considering the statistical power and sample size of the present study, we concluded that these SNPs are not associated with either AIS predisposition or curve severity in Japanese. ß

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mentioning

confidence: 99%

Lack of association between adolescent idiopathic scoliosis and previously reported single nucleotide polymorphisms in MATN1, MTNR1B, TPH1, and IGF1 in a Japanese population

Takahashi

Matsumoto

Karasugi

et al. 2011

Journal Orthopaedic Research

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“…Melatonin was first isolated from bovine pineal glands in 1969 (Lerner et al, 1969) and its chemical structure was determined. It was found to have (see Figure 1) a very short biological half-life and an N-acetyl and a 5-methoxy group are considered structural requirements for its bioactivity.…”

mentioning

confidence: 99%

Growth inhibitory and cytotoxic effects of melatonin and its metabolites on human tumour cell lines in vitro

Shellard

Whelan²,

Hill³

1989

Br J Cancer

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“…Melatonin is an ancient molecule which was first identified in the late 1950s [1]. It exists in almost every organism starting from the primitive ones as prokaryotes to the very complex organisms as the humans.…”

Section: Short Commentarymentioning

confidence: 99%

Improving Melatonin Delivery Within the Eye

Alkozi¹,

Pintor²

2017

J Bioequiv Availab

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ISOLATION OF 5-METHOXYINDOLE-3-ACETIC ACID FROM BOVINE PINEAL GLANDS¹

Cited by 133 publications

References 0 publications

Lack of association between adolescent idiopathic scoliosis and previously reported single nucleotide polymorphisms in MATN1, MTNR1B, TPH1, and IGF1 in a Japanese population

Lack of association between adolescent idiopathic scoliosis and previously reported single nucleotide polymorphisms in MATN1, MTNR1B, TPH1, and IGF1 in a Japanese population

Growth inhibitory and cytotoxic effects of melatonin and its metabolites on human tumour cell lines in vitro

Improving Melatonin Delivery Within the Eye

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ISOLATION OF 5-METHOXYINDOLE-3-ACETIC ACID FROM BOVINE PINEAL GLANDS1

Cited by 133 publications

References 0 publications

Lack of association between adolescent idiopathic scoliosis and previously reported single nucleotide polymorphisms in MATN1, MTNR1B, TPH1, and IGF1 in a Japanese population

Lack of association between adolescent idiopathic scoliosis and previously reported single nucleotide polymorphisms in MATN1, MTNR1B, TPH1, and IGF1 in a Japanese population

Growth inhibitory and cytotoxic effects of melatonin and its metabolites on human tumour cell lines in vitro

Improving Melatonin Delivery Within the Eye

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Product

Resources

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ISOLATION OF 5-METHOXYINDOLE-3-ACETIC ACID FROM BOVINE PINEAL GLANDS¹