“…Pharmacologically, caffeine inhibits muscle contraction (Youn et al, 1991), acts as the antagonist of the adenosine receptors to increase their plasmatic concentration (Conlay et al, 1997), potentiates the lethal effects of ionizing radiation which is important during the treatment of cancer (Sakurai et al, 1999), alters glucose metabolism (Greer et al, 2001), sensitizes calcium liberation channels and inhibits phosphodiesterase enzymes (Daly, 2007). Pure caffeine has antibacterial effect (Ramanaviciene et al, 2003a;Cogo et al, 2008;Mohammed & Al-Bayati, 2009), decreases the adherence of Streptococcus mutants to dental surface (Namboodiripad et al, 2007) and acts as the first dietary component able to protect one against Alzheimer's disease, Parkinson's disease and Huntington's disease (Ross et al, 2000;Lindsay et al, 2002;Ribeiro & Sebastiao, 2010). It increases the concentration of some immunocompetent cells and reinforces the activity of lysozyme to boost immunity against bacterial pathogens (Ramanaviciene et al, 2002;Ramanaviciene et al, 2003b;Vinod & Rangari, 2004).…”