Isolation, Characterization, and Nuclear Magnetic Resonance Spectra of New Saponins from the Roots of Bupleurum falcatum L.

Oleanene Glycosides of the Aerial Parts and Seeds of Bupleurum falcatum and the Aerial Parts of Bupleurum rotundifolium, and Their Evaluation as Anti-hepatitis Agents

“…Shibata et al reported isolation of various saponins from Bupleuri Radix originating from Bupleurum falcatum cultivated in Japan and the liver-protecting activity of a mixture of the major saponin, saikosaponin a, with other saponins. 1) Shimaoka et al reinvestigated the structure of saikosaponin, 2) and Tori et al conducted a 13 C-NMR investigation of saikosapogenins. 3) Ogihara and colleagues synthesized artificial derivatives of saikosaponins by using an acid or enzyme 4,5) and examined their function of accelerating corticosteroid secretion.…”

“…Various chromatographies on Diaion HP-20, Sephadex LH-20, silica gel, and Chromatorex octadecylsilyl (ODS) silica were applied to provide BFA-5 (108 mg), BFA-8 (1), BFA-22 (2), BFA-5 (3), BFA-6 (4), and BFA-25 (5) were identified as saikosaponin a, 3) saikosaponin c, 3) saikosaponin f, 3) saikosaponin b 2 , 2) and 4Љ-O-acetylsaikosaponin b 2 , 13) respectively, by fast atom bombardment-mass spectrometry (FAB-MS), 1 H-and (Table 1) displayed a total of 48 carbon signals, of which 30 were attributable to saikogenin D comprised of BFA-6 (4). The remaining carbon signals arose from sugar moieties and coincided with those of the sugar moieties in BFA-22 (2), as listed in Table 1.…”

The Effects of Saikosaponin-d on Yeast Phagocytosis and Degradation in Peritoneal Macrophages: Related Increase in Fc Receptor Expression and Altered Cytoplasmic Organization.

“…1) was isolated from the roots of Bupleurum falcatum L. by Dr. Ishii of Shio nogi Research Laboratory (Shionogi and Co. Ltd., Osaka, Japan) using the methods of Kubota et al (9) and Ishii et al (10). The purity of this compound was assessed by thin layer chromatography and 13C-NMR spectros copy.…”

Application of Saponin-Containing Plants in Foods and Cosmetics

“…Saponins 8-10 were separated from roots of Anemone rivularis [11]. Saponins 11-13 were isolated from bupleurum roots [12], and saponins 14 and 15 were prepared from 11 and 12, respectively by the reference [13]. Saponin 16 was isolated from roots of Kalopanax septemlobus [14].…”