Isolation, Characterization, and Medicinal Potential of Polysaccharides of Morchella esculenta

Badshah, Syed Lal; Riaz, Anila; Akhtar, Muhammad; Tel‐Çayan, Gülsen; Çayan, Fatih; Duru, Mehmet Emin; Ahmad, Nasir; Emwas, Abdul‐Hamid; Jaremko, Mariusz

doi:10.3390/molecules26051459

Cited by 46 publications

(19 citation statements)

References 43 publications

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“…In 2019, Deveci and colleagues reported that a polysaccharide obtained from Pleurotus ostreatus, a mushroom tree, exhibited significant inhibitory activity against BChE [172]. Badshah and colleagues reported that polysaccharides isolated from a wide range of mushrooms, which contain glucans, krestin, and lentinan, have significant AChE and BChE inhibitory activity and are being regarded as novel drug therapies for the management of AD and PD [173,174]. Also Badshah and colleagues have extracted mushroom polysaccharides from M. esculenta.…”

Section: Anticholinesterase Activity Of Polysaccharidesmentioning

confidence: 99%

“…This polysaccharide's deproteinized form has shown moderate free antioxidant activity but exhibited substantial AChE and BChE inhibitory properties. As a result, these polysaccharides are considered new therapeutic candidates for the treatment of AD and PD [174]. Another class of natural polysaccharides obtained from algae include fucoidans and fucose-containing sulfated polysaccharides such as glucose, mannose, galactose, and uronic acids [175].…”

Section: Anticholinesterase Activity Of Polysaccharidesmentioning

confidence: 99%

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Natural Polysaccharides as Preventive and Therapeutic Horizon for Neurodegenerative Diseases

et al. 2021

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Neurodegenerative diseases are a serious and widespread global public health burden amongst aging populations. The total estimated worldwide global cost of dementia was US$818 billion in 2015 and has been projected to rise to 2 trillion US$ by 2030. While advances have been made to understand different neurodegenerative disease mechanisms, effective therapeutic strategies do not generally exist. Several drugs have been proposed in the last two decades for the treatment of different types of neurodegenerative diseases, with little therapeutic benefit, and often with severe adverse and side effects. Thus, the search for novel drugs with higher efficacy and fewer drawbacks is an ongoing challenge in the treatment of neurodegenerative disease. Several natural compounds including polysaccharides have demonstrated neuroprotective and even therapeutic effects. Natural polysaccharides are widely distributed in plants, animals, algae, bacterial and fungal species, and have received considerable attention for their wide-ranging bioactivity, including their antioxidant, anti-neuroinflammatory, anticholinesterase and anti-amyloidogenic effects. In this review, we summarize different mechanisms involved in neurodegenerative diseases and the neuroprotective effects of natural polysaccharides, highlighting their potential role in the prevention and therapy of neurodegenerative disease.

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Section: Anticholinesterase Activity Of Polysaccharidesmentioning

confidence: 99%

Section: Anticholinesterase Activity Of Polysaccharidesmentioning

confidence: 99%

Natural Polysaccharides as Preventive and Therapeutic Horizon for Neurodegenerative Diseases

et al. 2021

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“…Although its use is limited by its high hydrophilicity and, in turn, its low membrane permeability [ 41 ], the existence of an inhibitor already in use as a dietary supplement could more rapidly direct antiseptic and anti-inflammatory drugs to ACLY. HCA fits into the wide range of natural compounds of pivotal importance for current disease treatments [ 55 , 56 ].…”

Section: Discussionmentioning

confidence: 99%

ACLY Nuclear Translocation in Human Macrophages Drives Proinflammatory Gene Expression by NF-κB Acetylation

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Todisco

et al. 2021

Cells

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Macrophage stimulation by pathogen-associated molecular patterns (PAMPs) like lipopolysaccharide (LPS) or lipoteichoic acid (LTA) drives a proinflammatory phenotype and induces a metabolic reprogramming to sustain the cell’s function. Nevertheless, the relationship between metabolic shifts and gene expression remains poorly explored. In this context, the metabolic enzyme ATP citrate lyase (ACLY), the producer of citrate-derived acetyl-coenzyme A (CoA), plays a critical role in supporting a proinflammatory response. Through immunocytochemistry and cytosol–nucleus fractionation, we found a short-term ACLY nuclear translocation. Protein immunoprecipitation unveiled the role of nuclear ACLY in NF-κB acetylation and in turn its full activation in human PBMC-derived macrophages. Notably, sepsis in the early hyperinflammatory phase triggers ACLY-mediated NF-κB acetylation. The ACLY/NF-κB axis increases the expression levels of proinflammatory genes, including SLC25A1—which encodes the mitochondrial citrate carrier—and ACLY, thus promoting the existence of a proinflammatory loop involving SLC25A1 and ACLY genes.

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“…Morchella esculenta is a mushroom which contains polysaccharides, mainly β-glucans with many properties. During a study in 2021 Badshah et al [ 156 ] have decided to define the association between free radical scavenging and AChE activity of two forms of these polysaccharides, proteinized and deproteinized. Their capability to inhibit AChE was compared with galanthamine as a reference standard.…”

Section: Antioxidants As the Prevention And Treatment Of Depression And Admentioning

confidence: 99%

Chronic Stress and Oxidative Stress as Common Factors of the Pathogenesis of Depression and Alzheimer’s Disease: The Role of Antioxidants in Prevention and Treatment

et al. 2021

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There is a growing body of scientific research showing the link between depression and dementia in Alzheimer’s disease (AD). The chronic stress contributes to the formation of oxidative stress in the parts of the brain involved in the development of depression and AD. The scientific literature reports the significant role of antioxidants, which are highly effective in treating these diseases. In this review, we have summarized the relationship between chronic stress, oxidative stress, and the changes in the brain they cause occurring in the brain. Among all the compounds showing antioxidant properties, the most promising results in AD treatment were observed for Vitamin E, coenzyme Q10 (CoQ10), melatonin, polyphenols, curcumin, and selenium. In case of depression treatment, the greatest potential was observed in curcumin, zinc, selenium, vitamin E, and saffron.

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Isolation, Characterization, and Medicinal Potential of Polysaccharides of Morchella esculenta

Cited by 46 publications

References 43 publications

Natural Polysaccharides as Preventive and Therapeutic Horizon for Neurodegenerative Diseases

Natural Polysaccharides as Preventive and Therapeutic Horizon for Neurodegenerative Diseases

ACLY Nuclear Translocation in Human Macrophages Drives Proinflammatory Gene Expression by NF-κB Acetylation

Chronic Stress and Oxidative Stress as Common Factors of the Pathogenesis of Depression and Alzheimer’s Disease: The Role of Antioxidants in Prevention and Treatment

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