Isolation, characterization, and evaluation of Cassia fistula Linn. seed and pulp polymer for pharmaceutical application

Abstract

Introduction:Present work, is an effort toward exploring the potential of Cassia fistula Linn. seed gum as an extended release polymer and laxative. While, C. fistula pulp polymer has evaluated as suspending agent.Materials and Methods:For extended release application, total five batches (F1-F5) were prepared by varying the ratio of drug:polymer as 1:1, 1:2, 1:3, 1:4, and 1:5, respectively. The granules were prepared by wet granulation method and further evaluated for micromeritic properties such as angle of repose (θ), Carr's compressibility index (CCI), and Hausner's ratio. Further compacts were evaluated by hardness, thickness, swelling index, in-vitro dissolution, and so on. Laxative activity was evaluated by administration of seed polymer (100 mg/kg) alone or in combination with bisacodyl (2.5 mg/kg) in 1% Tween 80. Zinc oxide suspension was prepared by varying the concentration of C. fistula pulp polymer and compared with suspension made by use of tragacanth, sodium carboxymethyl cellulose and bentonite.Results:Result showed that granules were free flowing, while the compact extended the drug release up to 10 h (72.84 ± 0.98; batch F5) and followed Higuchi matrix release kinetics. This extended release might be due to the formation of polyelectrolyte complex because of gluco-mannose in seed gum. Result of in-vivo laxative activity showed that seed polymer reduced faeces weight after 24 h compared to control (P < 0.01).Conclusions:Pulp polymer showed good sedimentation volume, but alone fails to stabilize the suspension for a longer period, so it could be useful in combination with other suspending agents and can be useful as novel excipient.

Traditional Herbal Remedies with a Multifunctional Therapeutic Approach as an Implication in COVID-19 Associated Co-Infections

“…The use of Cassia fistula as standardized formulations in the form of hand sanitizers and soaps has been widely used recently, and it needs further optimization for it to be used as a disinfectant and antiseptic. Apart from that, Cassia fistula seed gum has been used as a film coating material for drugs as well as for a variety of other pharmaceutical and bioengineering coating purposes [18]. The applicability of the Adhatoda vasica methanol extract in the preparation of medicinal liquid-based soaps, which demonstrated substantial antibacterial activity in liquid form compared to the dry extract type, has been well documented in previous studies [24].…”

“…Furthermore, they are used as standardized formulations in hand sanitizers and soaps, and they need further optimization for them to be used as disinfectant and antiseptics. Apart from that, Cassia fistula seed gum is used as a film coating material in different dosage forms for a variety of purposes [18]. Traditionally, the medicinal plant of the genus Moringa has been used to cure wounds and diseases such as common cold and diabetes.…”

Development and Characterization of Orodispersible Tablets of Propranolol Hydrochloride Using Calcium Cross-Linked Cassia Fistula Gum and Cross Carmellose Sodium

“…The obtained precipitate was washed sequentially with ethanol, diethyl ether and petroleum ether followed by drying at 40-45 °C. The final product was sifted through sieve number 120 and desiccated till further use [6][7][8]. Analytical techniques like FT-IR and NMR were employed to characterize the gum.…”

A comprehensive physicochemical, thermal, and spectroscopic characterization of zinc (II) chloride using X-ray diffraction, particle size distribution, differential scanning calorimetry, thermogravimetric analysis/differential thermogravimetric analysis, ultraviolet-visible, and Fourier transform-infrared spectroscopy

“…[234] Zinc chloride has the other applications includes protein precipitation, various insulin, and pharmaceutical preparations. [3456] It is the source of supplement for zinc to the animal body helpful for recovery from the deficiency syndromes (i.e., parakeratosis, hypogeusia, anorexia, dysosmia, geophagia, hypogonadism, growth retardation, and hepatosplenomegaly) and maintains the healthy quality of life. [27] In human, zinc resides in almost all the body parts, organs, or tissues (i.e., muscle, retina, prostate, bone, skin, kidney, liver, pancreas, red blood cells, and white blood cells) and plays important roles in several biological processes.…”

“…[2345612] Unfortunately, it scarce comprehensive, reliable, and accurate in-depth analytical information all together for the physicochemical, thermal, and spectroscopic characterization. However, to our knowledge, the structural characterization of zinc chloride using powder X-ray diffraction (PXRD), particle size distribution (PSD), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), differential thermogravimetric analysis (DTG), ultraviolet-visible spectroscopy (UV-vis) spectroscopy, and Fourier transform-infrared (FT-IR) spectrometry techniques have not yet been reported in details in any literature/book for the better understanding of its chemical structure.…”