Isolation, Characterization, and Chromosomal Localization of Mouse and Human COUP-TF I and II Genes

Qiu, Yin Long; Krishnan, Venkatesh; Zeng, Zhizhen; Gilbert, D. J.; Copeland, Neal G.; Gibson, Lisa H.; Yang‐Feng, Teresa L.; Jenkins, Nancy A.; Tsai, Ming Jer; Tsai, Sophia Y.

doi:10.1006/geno.1995.1237

Cited by 45 publications

(38 citation statements)

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“…The patterns of COUP-TFI and COUP-TFII expression overlap in development, but each factor possesses its own distinct profile. In addition, both genes are induced by retinoids (Jonk et al 1994b;Fjose et al 1995;Qiu et al 1995) and COUP-TFII is regulated by Sonic hedgehog signaling (Krishnan et al 1997a,b). Thus, the different expression profiles and regulation support the notion that each gene possesses a unique specific physiological role.…”

Section: Discussionmentioning

confidence: 99%

The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development

Pereira¹,

Qiu²,

Zhou³

et al. 1999

Genes & Development

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The embryonic expression of COUP-TFII, an orphan nuclear receptor, suggests that it may participate in mesenchymal-epithelial interactions required for organogenesis. Targeted deletion of the COUP-TFII gene results in embryonic lethality with defects in angiogenesis and heart development. COUP-TFII mutants are defective in remodeling the primitive capillary plexus into large and small microcapillaries. In the COUP-TFII mutant heart, the atria and sinus venosus fail to develop past the primitive tube stage. Reciprocal interactions between the endothelium and the mesenchyme in the vascular system and heart are essential for normal development of these systems. In fact, the expression of Angiopoietin-1, a proangiogenic soluble factor thought to mediate the mesenchymal-endothelial interactions during heart development and vascular remodeling, is down-regulated in COUP-TFII mutants. This down-regulation suggests that COUP-TFII may be required for bidirectional signaling between the endothelial and mesenchymal compartments essential for proper angiogenesis and heart development.

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Section: Discussionmentioning

confidence: 99%

The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development

Pereira¹,

Qiu²,

Zhou³

et al. 1999

Genes & Development

Self Cite

474

409

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“…Generation of conditional mutant of COUP-TFII Genomic DNA fragments, 7.2 kb BamHI-SalI, 1.4 kb SalI-XbaI and 1.4 kb XbaI-EcoRI from Q#10 clone and a 2.6 kb EcoRI-BamHI fragment from D-3.6RI clone containing COUP-TFII locus as described (Qiu et al, 1995) were subcloned into pBlueScriptII KS(+). The first loxP site was inserted into BglI site of 7.2 kb BamHI-SalI fragment and the NsiI site on the 2.6 kb EcoRI-BamHI fragment was modified with XhoI linker.…”

Section: Methodsmentioning

confidence: 99%

COUP-TFIIis essential for radial and anteroposterior patterning of the stomach

et al. 2005

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COUP-TFII, an orphan member of the steroid receptor superfamily,has been implicated in mesenchymal-epithelial interaction during organogenesis. The generation of a lacZ knock-in allele in the COUP-TFII locus in mice allows us to use X-gal staining to follow the expression of COUP-TFII in the developing stomach. We found COUP-TFII is expressed in the mesenchyme and the epithelium of the developing stomach. Conditional ablation of floxed COUP-TFII by Nkx3-2Cre recombinase in the gastric mesenchyme results in dysmorphogenesis of the developing stomach manifested by major patterning defects in posteriorization and radial patterning. The epithelial outgrowth,the expansion of the circular smooth muscle layer and enteric neurons as well as the posteriorization of the stomach resemble phenotypes exhibited by inhibition of hedgehog signaling pathways. Using organ cultures and cyclopamine treatment, we showed downregulation of COUP-TFII level in the stomach, suggesting COUP-TFII as a target of hedgehog signaling in the stomach. Our results are consistent with a functional link between hedgehog proteins and COUP-TFII, factors that are vital for epithelial-mesenchymal interactions.

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“…COUP-TFII, which maps to the central region of chromosome 7 in the mouse (9), has an onset of expression at embryonic day (E) 8.5 in the visceral mesoderm and differentiating myocardium of the sinus venosus and in the mesoderm surrounding the umbilical veins (10) (Tables 1 and 2). At E9.0, COUP-TFII transcripts are detected in the common atrium and in the mesenchyme of the developing umbilical veins, notochord, somite, hindbrain, and the otocyst as well as in the optic vesicle ( Table 1).…”

Section: Expression Patterns Of Coup-tfii In Mousementioning

confidence: 99%

Coup d'Etat: An Orphan Takes Control

et al. 2011

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Chicken ovalbumin upstream promoter transcription factors (COUP-TFs) belong to the steroid/thyroid hormone receptor superfamily. Cloning of their cDNAs demonstrated the existence of two distinct but related genes: COUP-TFI (EAR-3, NR2F1) and COUP-TFII (ARP-1, NR2F2). They are referred to as orphan receptors because ligands for COUP-TFs have yet to be identified. Since 1998, extensive studies have demonstrated their physiological importance in cell-fate specification, organogenesis, angiogenesis, and metabolism, as well as a variety of diseases. In this article, we will comprehensively review the biological functions of COUP-TFII and its underlying mechanism in various developmental processes and diseases. In addition, we will briefly summarize some of the current findings of COUP-TFI.

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Isolation, Characterization, and Chromosomal Localization of Mouse and Human COUP-TF I and II Genes

Cited by 45 publications

References 0 publications

The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development

The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development

COUP-TFIIis essential for radial and anteroposterior patterning of the stomach

Coup d'Etat: An Orphan Takes Control

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